Production of Virus-Derived Ping-Pong-Dependent piRNA-like Small RNAs in the Mosquito Soma

The natural maintenance cycles of many mosquito-borne pathogens require establishment of persistent non-lethal infections in the invertebrate host. The mechanism by which this occurs is not well understood, but we have previously shown that an antiviral response directed by small interfering RNAs (s...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 8; no. 1; p. e1002470
Main Authors:	Morazzani, Elaine M., Wiley, Michael R., Murreddu, Marta G., Adelman, Zach N., Myles, Kevin M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.01.2012 Public Library of Science (PLoS)
Subjects:	Alphavirus Alphavirus - physiology Alphavirus Infections - genetics Alphavirus Infections - metabolism Animals Anopheles Aquatic insects Biology Cell Line Culicidae Health aspects Insect Proteins - genetics Insect Proteins - metabolism Insects Insects as carriers of disease Interspersed Repetitive Sequences Mosquitoes Pathogenesis Physiological aspects Proteins Ribonuclease III - genetics Ribonuclease III - metabolism Ribonucleic acid RNA RNA, Small Interfering - biosynthesis RNA, Small Interfering - genetics RNA, Viral - biosynthesis RNA, Viral - genetics Viral infections Virus Replication - physiology Viruses United States
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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