Impact of Visceral Fat on Skeletal Muscle Mass and Vice Versa in a Prospective Cohort Study: The Korean Sarcopenic Obesity Study (KSOS)

Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. We observed changes...

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Veröffentlicht in:	PloS one Jg. 9; H. 12; S. e115407
Hauptverfasser:	Kim, Tae Nyun, Park, Man Sik, Ryu, Ja Young, Choi, Hae Yoon, Hong, Ho Cheol, Yoo, Hye Jin, Kang, Hyun Joo, Song, Wook, Park, Seok Won, Baik, Sei Hyun, Newman, Anne B., Choi, Kyung Mook
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 17.12.2014 Public Library of Science (PLoS)
Schlagworte:	Absorptiometry, Photon Adipose tissue Adult Adults Age Aged Aged, 80 and over Aging Anthropometry Body composition Body fat Body mass Body Mass Index Body measurements Body size C-reactive protein C-Reactive Protein - analysis Cohort analysis Computed tomography Correlation analysis Diabetes Dual energy X-ray absorptiometry Endocrinology Energy consumption Energy measurement Exercise Female Follow-Up Studies Humans Incidence Insulin Insulin resistance Internal medicine Intra-Abdominal Fat - physiopathology Longitudinal Studies Male Mathematical analysis Medical imaging Medicine Medicine and Health Sciences Metabolic disorders Middle Aged Muscles Musculoskeletal system Obesity Obesity, Abdominal - complications Older people Parameter sensitivity Physical education Physical fitness Prognosis Prospective Studies Regression analysis Republic of Korea Risk Factors Sarcopenia Sarcopenia - epidemiology Sarcopenia - etiology Sarcopenia - pathology Skeletal muscle Statistical analysis Tomography, X-Ray Computed Tumor necrosis factor-TNF Vitamin D Vitamin deficiency Womens health Young Adult Republic of Korea United States > US
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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Zusammenfassung:	Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. We observed changes in anthropometric and body composition data during a follow-up period of 27.6 ± 2.8 months in 379 Korean men and women (mean age 51.9 ± 14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P = 0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P = 0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P = 0.555). This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: KMC MSP TNK. Performed the experiments: TNK JYR HCH HYC MSP. Analyzed the data: WS HJK MSP. Contributed reagents/materials/analysis tools: HJY HJK WS SWP SHB ABN. Wrote the paper: TNK KMC.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0115407