Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia

β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma chain and the presence of pathological free iron promote severe oxidative damage, playing crucial a role in erythrocyte hemolysis, exa...

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Bibliographic Details
Published in:	PloS one Vol. 13; no. 12; p. e0208316
Main Authors:	Romanello, Karen S., Teixeira, Karina K. L., Silva, João Pedro M. O., Nagamatsu, Sheila T., Bezerra, Marcos André C., Domingos, Igor F., Martins, Diego A. P., Araujo, Aderson S., Lanaro, Carolina, Breyer, Carlos A., Ferreira, Regiane A., Franco-Penteado, Carla, Costa, Fernando F., Malavazi, Iran, Netto, Luis E. S., de Oliveira, Marcos A., Cunha, Anderson F.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.12.2018 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Alpha iron Analysis Anemia Antioxidants Antioxidants (Nutrients) beta-Thalassemia - metabolism beta-Thalassemia - pathology Biology and Life Sciences Blood cells Blotting, Western Catalase Chains Chemistry Child Child, Preschool DNA binding proteins Enzymes Erythrocytes Erythrocytes - cytology Erythrocytes - metabolism Erythroid cells Erythroid Cells - metabolism Erythropoiesis Female Genes Glutathione Glutathione peroxidase Health aspects Hemoglobin Hemolysis Hemolytic anemia Humans Hydrogen Hydrogen peroxide Iron Isoforms Kinases Leukocytes (mononuclear) Leukocytes (neutrophilic) Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Life span Male Medical law Medicine and Health Sciences Middle Aged Mutation Neutrophils - cytology Neutrophils - metabolism Oxidation-Reduction Oxidative stress Patients Peroxidase Peroxides Peroxiredoxins - genetics Peroxiredoxins - metabolism Physical Sciences Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Reducing agents Superoxide dismutase Thalassemia Transcription factors Young Adult Massachusetts Brazil
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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