Profiling of Parkin-Binding Partners Using Tandem Affinity Purification

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting approximately 1-2% of the general population over age 60. It is characterized by a rather selective loss of dopaminergic neurons in the substantia nigra and the presence of α-synuclein-enriched Lewy body inclusions....

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Vydáno v:	PloS one Ročník 8; číslo 11; s. e78648
Hlavní autoři:	Zanon, Alessandra, Rakovic, Aleksandar, Blankenburg, Hagen, Doncheva, Nadezhda T., Schwienbacher, Christine, Serafin, Alice, Alexa, Adrian, Weichenberger, Christian X., Albrecht, Mario, Klein, Christine, Hicks, Andrew A., Pramstaller, Peter P., Domingues, Francisco S., Pichler, Irene
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 11.11.2013 Public Library of Science (PLoS)
Témata:	Acids Affinity Age Animals Basal ganglia Binding proteins Bioinformatics Biological activity Biology Cell cycle Cell death Cell Line, Tumor Central nervous system diseases Depolarization Dopamine Dopamine receptors Drosophila Drosophila melanogaster Drosophila Proteins - genetics Drosophila Proteins - isolation & purification Drosophila Proteins - metabolism Fusion protein Gene expression Genes Genetic aspects Health screening Humans Immunoprecipitation Informatics Insects Lewy bodies Machinery Machinery and equipment Mass spectrometry Mass spectroscopy Mitochondria Movement disorders Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - isolation & purification Nerve Tissue Proteins - metabolism Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurons Ontology Parkin protein Parkinson disease Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson's disease Protein Binding Protein folding Protein interaction Protein purification Protein-protein interactions Proteins Purification Screens Substantia nigra Synuclein Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - isolation & purification Ubiquitin-Protein Ligases - metabolism Italy Germany
ISSN:	1932-6203, 1932-6203
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