Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway

Heart rate variability is an important risk factor for cardiovascular disease and all-cause mortality. The acetylcholine pathway plays a key role in explaining heart rate variability in humans. We assessed whether 443 genotyped and imputed common genetic variants in eight key genes (CHAT, SLC18A3, S...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 11; p. e112476
Main Authors:	Riese, Harriëtte, Muñoz, Loretto M., Hartman, Catharina A., Ding, Xiuhua, Su, Shaoyong, Oldehinkel, Albertine J., van Roon, Arie M., van der Most, Peter J., Lefrandt, Joop, Gansevoort, Ron T., van der Harst, Pim, Verweij, Niek, Licht, Carmilla M. M., Boomsma, Dorret I., Hottenga, Jouke-Jan, Willemsen, Gonneke, Penninx, Brenda W. J. H., Nolte, Ilja M., de Geus, Eco J. C., Wang, Xiaoling, Snieder, Harold
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 10.11.2014 Public Library of Science (PLoS)
Subjects:	Acetylcholine Acetylcholine - metabolism Acetylcholinesterase Adolescent Adult Analysis Biology and Life Sciences Cardiology Cardiovascular diseases Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Child Cohort Studies Epidemiology European Continental Ancestry Group - genetics Female Genes Genetic Association Studies Genetic diversity Genetic variance Genome-wide association studies Genomes Genomics Health aspects Health psychology Health risks Heart rate Heart Rate - genetics Humans Hypertension Interdisciplinary aspects Male Medicine Medicine and Health Sciences Meta-analysis Middle Aged Mortality Nervous system Outdoor air quality Parasympathetic nervous system Pediatrics Polymorphism, Single Nucleotide Psychiatry Psychopathology Risk factors Signal Transduction Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Twins Variability Young Adult United States > US Netherlands Georgia
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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