Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes

Although obesity and cardiometabolic traits commonly overlap, underlying pathways remain incompletely defined. The association of metabolite profiles across multiple cardiometabolic traits may lend insights into the interaction of obesity and metabolic health. We sought to investigate metabolic sign...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 2; p. e0148361
Main Authors:	Ho, Jennifer E., Larson, Martin G., Ghorbani, Anahita, Cheng, Susan, Chen, Ming-Huei, Keyes, Michelle, Rhee, Eugene P., Clish, Clary B., Vasan, Ramachandran S., Gerszten, Robert E., Wang, Thomas J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 10.02.2016 Public Library of Science (PLoS)
Subjects:	Adipose tissue Adult Amino acids Biology and Life Sciences Blood Blood Glucose - metabolism Blood pressure Body mass Body Mass Index Cardiovascular diseases Chain branching Citric acid Cotinine Diabetes Dyslipidemia Dyslipidemias - blood Fasting Female Genetic aspects Genetic crosses Glucose Health risk assessment Heart Humans Hyperglycemia Hypertension Insulin Insulin Resistance Isoleucine Ketoglutaric acid Kynurenic acid Leucine Male Medicine and Health Sciences Metabolic Networks and Pathways Metabolic pathways Metabolites Metabolome Metabolomics Myocardium - metabolism Obesity Obesity - blood Offspring Ornithine Pathways Phenotype Phenylalanine Profiling Prospective Studies Tricarboxylic acid cycle Tryptophan Tyrosine Urea Valine United States United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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