Cell Cycle- and Cancer-Associated Gene Networks Activated by Dsg2: Evidence of Cystatin A Deregulation and a Potential Role in Cell-Cell Adhesion

Cell-cell adhesion is paramount in providing and maintaining multicellular structure and signal transmission between cells. In the skin, disruption to desmosomal regulated intercellular connectivity may lead to disorders of keratinization and hyperproliferative disease including cancer. Recently we...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0120091
Main Authors:	Gupta, Abhilasha, Nitoiu, Daniela, Brennan-Crispi, Donna, Addya, Sankar, Riobo, Natalia A., Kelsell, David P., Mahoney, Mỹ G.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18.03.2015 Public Library of Science (PLoS)
Subjects:	Adhesion Animals Biochemistry Breast cancer Calcium Cancer Cancer genetics Cell Adhesion Cell adhesion & migration Cell Cycle Cell Line, Tumor Crosstalk Cystatin A - genetics Cystatin A - metabolism Cystatins Cysteine Cysteine proteinase Cytokeratin Dentistry Deregulation Dermatology Desmoglein 2 - genetics Desmoglein 2 - metabolism Disorders DNA microarrays Dysplasia Epidermis Fragility Gene expression Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genes Genetic aspects Genetic engineering Humans Hyperplasia Ichthyosis Immunoblotting Immunohistochemistry Keratin Keratinization Keratinocytes Keratinocytes - cytology Keratinocytes - metabolism Kinases Localization Medical prognosis Mice Mice, Transgenic Molecular biology Mutation Network analysis Oligonucleotide Array Sequence Analysis Protease inhibitors Proteases Protein binding Proteinase inhibitors Proteins Rodents Signal transmission siRNA Skin Skin cancer Skin diseases Squamous cell carcinoma Transcriptome Transgenic animals Transgenic mice United Kingdom > UK United States > US Pennsylvania
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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