Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines

To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may play a key role in cancer dissemination. Uncovering CTC phenotypes offers a potential avenue to inform treatment. However, C...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 5; p. e33788
Main Authors:	Powell, Ashley A., Talasaz, AmirAli H., Zhang, Haiyu, Coram, Marc A., Reddy, Anupama, Deng, Glenn, Telli, Melinda L., Advani, Ranjana H., Carlson, Robert W., Mollick, Joseph A., Sheth, Shruti, Kurian, Allison W., Ford, James M., Stockdale, Frank E., Quake, Stephen R., Pease, R. Fabian, Mindrinos, Michael N., Bhanot, Gyan, Dairkee, Shanaz H., Davis, Ronald W., Jeffrey, Stefanie S.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07.05.2012 Public Library of Science (PLoS)
Subjects:	Analysis Antigens Biochemistry Bioengineering Biology Biopsy Biotechnology Blood Blood circulation Breast cancer Breast Neoplasms - blood Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cancer metastasis Cancer treatment Cell Line, Tumor Contamination CXCR4 protein Drug discovery Electrical engineering Engineering Epidermal growth factor Feasibility studies Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic aspects Genomes Health aspects Heterogeneity Humans Kinases Leukocytes Lymphoma - blood Medical research Medicine Mesenchyme Metastases Metastasis Microarray Analysis - methods Microfluidic Analytical Techniques Microfluidics Molecular biology Motility Neoplasm Metastasis Neoplastic Cells, Circulating - metabolism Pancreatic cancer Patients Prostate Rodents S100A4 protein Single-Cell Analysis - instrumentation Single-Cell Analysis - methods Solid tumors Stem cells Subgroups Surgery Therapy Transcription Transcription (Genetics) Transforming growth factors Tumor cell lines Tumor cells Tumors Palo Alto California California United States > US New Brunswick New Jersey
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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