A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 2; p. e88714
Main Authors:	Llop-Guevara, Alba, Chu, Derek K., Walker, Tina D., Goncharova, Susanna, Fattouh, Ramzi, Silver, Jonathan S., Moore, Cheryl Lynn, Xie, Juliana L., O’Byrne, Paul M., Coyle, Anthony J., Kolbeck, Roland, Humbles, Alison A., Stämpfli, Martin R., Jordana, Manel
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 14.02.2014 Public Library of Science (PLoS)
Subjects:	Allergens Allergies Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - pathology Alveoli Analysis Animals Asthma B cells Biology CD11b antigen Cytokines Dust Epithelial cells Exposure Female Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology House dust Humans Hypersensitivity Hypersensitivity - immunology Hypersensitivity - parasitology Immunity - drug effects Immunology Inflammation Inflammation - complications Inflammation - immunology Inflammation - pathology Interleukin-1alpha - metabolism Interleukin-33 Interleukins - metabolism Leukocytes (eosinophilic) Ligands Lung - immunology Lung - parasitology Lung - pathology Lungs Lymphocytes T Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Macrophages, Alveolar - pathology Medicine Mice Mice, Inbred BALB C Mites Models, Immunological Mucus Ox40L protein Pathology Pollutants Pollution control Pyroglyphidae - drug effects Pyroglyphidae - immunology Respiratory tract Time Factors
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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