A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PloS one Ročník 9; číslo 2; s. e88714
Hlavní autoři:	Llop-Guevara, Alba, Chu, Derek K., Walker, Tina D., Goncharova, Susanna, Fattouh, Ramzi, Silver, Jonathan S., Moore, Cheryl Lynn, Xie, Juliana L., O’Byrne, Paul M., Coyle, Anthony J., Kolbeck, Roland, Humbles, Alison A., Stämpfli, Martin R., Jordana, Manel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 14.02.2014 Public Library of Science (PLoS)
Témata:	Allergens Allergies Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - pathology Alveoli Analysis Animals Asthma B cells Biology CD11b antigen Cytokines Dust Epithelial cells Exposure Female Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology House dust Humans Hypersensitivity Hypersensitivity - immunology Hypersensitivity - parasitology Immunity - drug effects Immunology Inflammation Inflammation - complications Inflammation - immunology Inflammation - pathology Interleukin-1alpha - metabolism Interleukin-33 Interleukins - metabolism Leukocytes (eosinophilic) Ligands Lung - immunology Lung - parasitology Lung - pathology Lungs Lymphocytes T Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Macrophages, Alveolar - pathology Medicine Mice Mice, Inbred BALB C Mites Models, Immunological Mucus Ox40L protein Pathology Pollutants Pollution control Pyroglyphidae - drug effects Pyroglyphidae - immunology Respiratory tract Time Factors
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b(+) DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1α. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1α. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway.
AbstractList	Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b(+) DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1α. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1α. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway.Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b(+) DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1α. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1α. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway. Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b.sup.+ DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1[alpha]. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1[alpha]. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway. Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction of individuals. This is likely related, at least in part, to the extent of allergen exposure. Regarding house dust mite (HDM), we previously identified the threshold required to elicit allergic responses in BALB/c mice. Here, we investigated the impact of an initial immune perturbation on the response to sub-threshold HDM exposure. We show that transient GM-CSF expression in the lung facilitated robust eosinophilic inflammation, long-lasting antigen-specific Th2 responses, mucus production and airway hyperresponsiveness. This was associated with increased IL-33 levels and activated CD11b+ DCs expressing OX40L. GM-CSF-driven allergic responses were significantly blunted in IL-33-deficient mice. IL-33 was localized on alveolar type II cells and in vitro stimulation of human epithelial cells with GM-CSF enhanced intracellular IL-33 independently of IL-1α. Likewise, GM-CSF administration in vivo resulted in increased levels of IL-33 but not IL-1α. These findings suggest that exposures to environmental agents associated with GM-CSF production, including airway infections and pollutants, may decrease the threshold of allergen responsiveness and, hence, increase the susceptibility to develop allergic asthma through a GM-CSF/IL-33/OX40L pathway.
Audience	Academic
Author	Kolbeck, Roland Stämpfli, Martin R. Moore, Cheryl Lynn Chu, Derek K. Humbles, Alison A. Silver, Jonathan S. O’Byrne, Paul M. Fattouh, Ramzi Walker, Tina D. Jordana, Manel Llop-Guevara, Alba Goncharova, Susanna Xie, Juliana L. Coyle, Anthony J.
AuthorAffiliation	National Jewish Health, United States of America 4 Pfizer, Cambridge, Massachusetts, United States of America 3 Department of Medicine, McMaster University, Hamilton, Ontario, Canada 1 Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada 2 Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, United States of America
AuthorAffiliation_xml	– name: National Jewish Health, United States of America – name: 1 Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada – name: 2 Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, United States of America – name: 3 Department of Medicine, McMaster University, Hamilton, Ontario, Canada – name: 4 Pfizer, Cambridge, Massachusetts, United States of America
Author_xml	– sequence: 1 givenname: Alba surname: Llop-Guevara fullname: Llop-Guevara, Alba – sequence: 2 givenname: Derek K. surname: Chu fullname: Chu, Derek K. – sequence: 3 givenname: Tina D. surname: Walker fullname: Walker, Tina D. – sequence: 4 givenname: Susanna surname: Goncharova fullname: Goncharova, Susanna – sequence: 5 givenname: Ramzi surname: Fattouh fullname: Fattouh, Ramzi – sequence: 6 givenname: Jonathan S. surname: Silver fullname: Silver, Jonathan S. – sequence: 7 givenname: Cheryl Lynn surname: Moore fullname: Moore, Cheryl Lynn – sequence: 8 givenname: Juliana L. surname: Xie fullname: Xie, Juliana L. – sequence: 9 givenname: Paul M. surname: O’Byrne fullname: O’Byrne, Paul M. – sequence: 10 givenname: Anthony J. surname: Coyle fullname: Coyle, Anthony J. – sequence: 11 givenname: Roland surname: Kolbeck fullname: Kolbeck, Roland – sequence: 12 givenname: Alison A. surname: Humbles fullname: Humbles, Alison A. – sequence: 13 givenname: Martin R. surname: Stämpfli fullname: Stämpfli, Martin R. – sequence: 14 givenname: Manel surname: Jordana fullname: Jordana, Manel
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24551140$$D View this record in MEDLINE/PubMed
BookMark	eNqNk29r2zAQxs3oWP9s32BshsHYXjiVLFmy-2IQsqYNpHQ03d4KWZYTFcXKJHlrv_3kxhlxKWP4hc3d757zPdwdRweNaWQUvYVgBBGFp3emtQ3Xo00IjwDIcwrxi-gIFihNSArQwd73YXTs3B0AGcoJeRUdpjjLIMTgKKrH8cVVMllMT2fzBKH4G_er3_whnnKhtPLcSxePtZZ2qUQ8VrbL3UgXmrqQ8SZetGVyu7LSrYyu4kvTOhl_bZ2Pr5SX8fn9xrjWytfRy5prJ9_075Po-_T8dnKZzK8vZpPxPBE0y31Cy1IKVANc4xzWklei4iLPsKhIVhQ0BYRnlGJCYU7KCpQVLhFMcSlERQXIKDqJ3m91N9o41lvkGMRFniKKKQrEbEtUht-xjVVrbh-Y4Yo9BoxdMm69EloyUHBCBOKyqAtc1LIo0rpCUKYEIIFwFrS-9N3aci0rIRtvuR6IDjONWrGl-cVQkWbw8Xc_9QLW_Gyl82ytnJBa80YGJxnMACB5StOu14cn6PPT9dSShwFUU5vQV3SibIxpngNEYEeNnqHCU8m1EmGfahXig4LPg4LAeHnvl7x1js0WN__PXv8Ysh_32JXk2q-c0a1XYb-G4Lt9p_9avFvkAJxtAWGNc1bWTHTbG3TCaEozCFh3NTvTWHc1rL-aUIyfFO_0_1n2B7CDGXE
CitedBy_id	crossref_primary_10_1155_2020_4087315 crossref_primary_10_1126_science_aac6623 crossref_primary_10_3390_ijms21207487 crossref_primary_10_1186_s40200_016_0264_4 crossref_primary_10_1038_mi_2016_90 crossref_primary_10_1016_S2665_9913_20_30340_4 crossref_primary_10_1111_imr_12542 crossref_primary_10_4049_jimmunol_1601691 crossref_primary_10_1016_j_jaci_2020_07_038 crossref_primary_10_1186_s13223_015_0081_1 crossref_primary_10_1016_j_jaci_2017_02_025 crossref_primary_10_1016_j_pupt_2020_101963 crossref_primary_10_1124_jpet_114_222505 crossref_primary_10_1172_JCI97720 crossref_primary_10_1016_j_mam_2021_100995 crossref_primary_10_1007_s43630_025_00743_6 crossref_primary_10_1038_nrd_2016_231 crossref_primary_10_3390_ijms232113242 crossref_primary_10_1016_j_jaci_2022_09_030 crossref_primary_10_1038_mi_2017_71 crossref_primary_10_1021_acs_est_5c02782 crossref_primary_10_1089_jir_2016_0112 crossref_primary_10_1172_JCI124606 crossref_primary_10_1038_s41598_018_19837_6 crossref_primary_10_1016_j_jaci_2015_03_011 crossref_primary_10_1084_jem_20240103 crossref_primary_10_1165_rcmb_2016_0151PS crossref_primary_10_1016_j_imlet_2017_01_003 crossref_primary_10_1016_j_iac_2022_04_004 crossref_primary_10_1016_j_immuni_2015_07_007 crossref_primary_10_1111_cei_12409 crossref_primary_10_1111_all_15679 crossref_primary_10_3390_biomedicines10051183 crossref_primary_10_3390_ijms21249508 crossref_primary_10_7554_eLife_65614 crossref_primary_10_1371_journal_pone_0157571 crossref_primary_10_1111_imr_12560 crossref_primary_10_1016_j_jaci_2018_08_037 crossref_primary_10_1016_j_waojou_2023_100786 crossref_primary_10_1016_j_intimp_2024_113708 crossref_primary_10_1586_1744666X_2015_1024110 crossref_primary_10_1111_sji_12312 crossref_primary_10_1084_jem_20190945 crossref_primary_10_1155_2016_9858374 crossref_primary_10_4049_jimmunol_2000885 crossref_primary_10_1016_j_jaci_2016_02_039 crossref_primary_10_1016_j_imlet_2018_11_012 crossref_primary_10_1016_j_smim_2021_101523 crossref_primary_10_1016_j_cellimm_2021_104438 crossref_primary_10_1016_j_jbc_2021_100428
Cites_doi	10.1016/j.immuni.2005.09.015 10.1378/chest.123.3_suppl.438S 10.1165/rcmb.2008-0107OC 10.2174/187152808786848388 10.2353/ajpath.2008.080014 10.1038/nm.1946 10.1084/jem.190.7.895 10.1172/JCI4160 10.1155/2012/834826 10.1038/ni.2045 10.1111/j.1398-9995.2006.01300.x 10.1099/jmm.0.005488-0 10.1126/science.284.5411.89 10.1016/j.bbrc.2009.06.008 10.1084/jem.190.10.1541 10.1152/ajplung.2001.280.3.L493 10.1084/jem.20112691 10.1073/pnas.0606854104 10.4049/jimmunol.1101977 10.1152/ajplung.00021.2009 10.4049/jimmunol.0802449 10.1046/j.1365-2249.1998.00652.x 10.1084/jem.20101563 10.1016/j.jaci.2004.05.072 10.1016/j.jaci.2009.12.935 10.1152/ajplung.00056.2007 10.1111/j.1365-2222.2009.03384.x 10.1165/ajrcmb.16.5.9160833 10.1084/jem.20110079 10.4049/jimmunol.0802387 10.1073/pnas.1201042109 10.1002/eji.201242863 10.4049/jimmunol.1002558 10.1002/9781444346688.ch14 10.1016/j.jaci.2012.08.002 10.1371/journal.pone.0003331 10.1093/intimm/dxn037 10.1371/journal.pone.0002426 10.1038/jid.2012.185 10.1111/j.1398-9995.2004.00526.x 10.1016/j.imlet.2010.04.005 10.1164/rccm.200706-958OC 10.1164/rccm.200308-1094OC 10.1084/jem.191.6.1069
ContentType	Journal Article
Copyright	COPYRIGHT 2014 Public Library of Science 2014 Llop-Guevara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Llop-Guevara et al 2014 Llop-Guevara et al
Copyright_xml	– notice: COPYRIGHT 2014 Public Library of Science – notice: 2014 Llop-Guevara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2014 Llop-Guevara et al 2014 Llop-Guevara et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0088714
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Opposing Viewpoints (Gale In Context) Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (ProQuest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals (DOAJ)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Agricultural Science Database MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Medicine Biology
DocumentTitleAlternate	GM-CSF Increases HDM Susceptibility via IL-33
EISSN	1932-6203
ExternalDocumentID	1498237473 oai_doaj_org_article_09a66c3ae9f949fe992fd31e2603c345 PMC3925157 3219289381 A478803613 24551140 10_1371_journal_pone_0088714
Genre	Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: Canadian Institutes of Health Research grantid: 87517
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF IPNFZ NPM PV9 RIG RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP KM
ID	FETCH-LOGICAL-c758t-7bbec3f04f481feadcdac854cd65997206a577467186bd0bd4b3124bccd7c0573
IEDL.DBID	DOA
ISICitedReferencesCount	57
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000331271500056&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Fri Nov 26 17:14:06 EST 2021 Tue Oct 14 19:07:19 EDT 2025 Tue Nov 04 01:55:26 EST 2025 Wed Oct 01 14:09:01 EDT 2025 Tue Oct 07 07:09:25 EDT 2025 Sat Nov 29 13:13:52 EST 2025 Sat Nov 29 10:13:48 EST 2025 Wed Nov 26 09:56:39 EST 2025 Wed Nov 26 09:51:14 EST 2025 Thu May 22 21:16:27 EDT 2025 Mon Jul 21 06:02:42 EDT 2025 Sat Nov 29 02:39:18 EST 2025 Tue Nov 18 22:15:16 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c758t-7bbec3f04f481feadcdac854cd65997206a577467186bd0bd4b3124bccd7c0573
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Current address: The Hospital for Sick Children (Sick Kids), Toronto, Ontario, Canada Conceived and designed the experiments: ALG DKC RF JSS AAH MRS MJ. Performed the experiments: ALG DKC TDW SG JSS CLM JLX. Analyzed the data: ALG DKC MJ. Contributed reagents/materials/analysis tools: RK AAH. Wrote the paper: ALG MJ. Provided guidance and critical appraisal of the manuscript: PMO AJC AAH MRS MJ. Current address: Rollins School of Public Health, Atlanta, Georgia, United States of America Competing Interests: As requested, note that the authors Dr. Jonathan S. Silver, Roland Kolbeck and Alison A. Humbles are current employees of MedImmune LLC; and Anthony J. Coyle is a current employee of Pfizer. Therefore, the authors state that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.
OpenAccessLink	https://doaj.org/article/09a66c3ae9f949fe992fd31e2603c345
PMID	24551140
PQID	1498237473
PQPubID	1436336
PageCount	e88714
ParticipantIDs	plos_journals_1498237473 doaj_primary_oai_doaj_org_article_09a66c3ae9f949fe992fd31e2603c345 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3925157 proquest_miscellaneous_1500682725 proquest_journals_1498237473 gale_infotracmisc_A478803613 gale_infotracacademiconefile_A478803613 gale_incontextgauss_ISR_A478803613 gale_incontextgauss_IOV_A478803613 gale_healthsolutions_A478803613 pubmed_primary_24551140 crossref_citationtrail_10_1371_journal_pone_0088714 crossref_primary_10_1371_journal_pone_0088714
PublicationCentury	2000
PublicationDate	2014-02-14
PublicationDateYYYYMMDD	2014-02-14
PublicationDate_xml	– month: 02 year: 2014 text: 2014-02-14 day: 14
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2014
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	AM Kuchler (ref15) 2008; 173 D Prefontaine (ref18) 2009; 183 NJ Trimble (ref25) 2009; 40 D Prefontaine (ref14) 2010; 125 M Wills-Karp (ref12) 2012; 209 YJ Chang (ref13) 2011; 12 L Demaio (ref17) 2009; 296 R Fattouh (ref44) 2008; 7 XF Lei (ref7) 1998; 113 M Yamaya (ref24) 2012; 2012 JR Johnson (ref8) 2004; 169 GM Whitesides (ref4) 1999; 284 H Hammad (ref21) 2009; 15 J Meephansan (ref19) 2012; 132 T Ohno (ref42) 2009; 183 M Masoli (ref2) 2004; 59 M Pichery (ref40) 2012; 188 R Fattouh (ref45) 2008; 177 MR Stampfli (ref6) 1998; 102 ref41 MP Nelson (ref39) 2011; 186 DE Smith (ref31) 2010; 40 K Hoshino (ref35) 1999; 190 J Sunyer (ref1) 2004; 114 K Yasuda (ref38) 2012; 109 JQ He (ref27) 2003; 123 J Schmitz (ref11) 2005; 23 X Liu (ref37) 2009; 386 ref9 AJ Coyle (ref34) 1999; 190 V Carriere (ref43) 2007; 104 AP Bellanger (ref23) 2009; 58 Y Ohkawara (ref29) 1997; 16 A Llop-Guevara (ref3) 2008; 3 ref5 MJ Townsend (ref36) 2000; 191 X Zhiguang (ref33) 2010; 131 M Kabesch (ref28) 2007; 62 Y Kondo (ref32) 2008; 20 MA Willart (ref20) 2012; 209 H Hammad (ref30) 2010; 207 JR Johnson (ref10) 2007; 293 D Kube (ref22) 2001; 280 C Moussion (ref16) 2008; 3 S Boland (ref26) 1999; 276 18545674 - PLoS One. 2008;3(6):e2426 19329539 - Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1051-8 21623379 - Nat Immunol. 2011 Jul;12(7):631-8 18635815 - Am J Respir Cell Mol Biol. 2009 Jan;40(1):38-46 22802353 - J Exp Med. 2012 Jul 30;209(8):1505-17 10727469 - J Exp Med. 2000 Mar 20;191(6):1069-76 19801525 - J Immunol. 2009 Oct 15;183(8):5094-103 18448455 - Int Immunol. 2008 Jun;20(6):791-800 16286016 - Immunity. 2005 Nov;23(5):479-90 14597485 - Am J Respir Crit Care Med. 2004 Feb 1;169(3):378-85 19075788 - Inflamm Allergy Drug Targets. 2008 Dec;7(4):224-36 15080825 - Allergy. 2004 May;59(5):469-78 9717963 - Clin Exp Immunol. 1998 Aug;113(2):157-65 22673732 - J Invest Dermatol. 2012 Nov;132(11):2593-600 10562328 - J Exp Med. 1999 Nov 15;190(10):1541-8 18836528 - PLoS One. 2008;3(10):e3331 19508862 - Biochem Biophys Res Commun. 2009 Aug 14;386(1):181-5 19933859 - J Immunol. 2009 Dec 15;183(12):7890-7 21220696 - J Immunol. 2011 Feb 15;186(4):2372-81 22371395 - J Immunol. 2012 Apr 1;188(7):3488-95 20819925 - J Exp Med. 2010 Sep 27;207(10):2097-111 20153038 - J Allergy Clin Immunol. 2010 Mar;125(3):752-4 10198358 - Am J Physiol. 1999 Apr;276(4 Pt 1):L604-13 22331917 - Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3451-6 17185418 - Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7 23006545 - J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8 18174546 - Am J Respir Crit Care Med. 2008 Mar 15;177(6):593-603 9160833 - Am J Respir Cell Mol Biol. 1997 May;16(5):510-20 19906013 - Clin Exp Allergy. 2010 Feb;40(2):200-8 18787100 - Am J Pathol. 2008 Oct;173(4):1229-42 17586699 - Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L730-9 23169007 - Eur J Immunol. 2013 Feb;43(2):488-98 12629028 - Chest. 2003 Mar;123(3 Suppl):438S 10102824 - Science. 1999 Apr 2;284(5411):89-92 17362254 - Allergy. 2007 Apr;62(4):423-8 20412815 - Immunol Lett. 2010 Jul 8;131(2):159-65 11159033 - Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L493-502 9802884 - J Clin Invest. 1998 Nov 1;102(9):1704-14 15536406 - J Allergy Clin Immunol. 2004 Nov;114(5):1033-9 10510079 - J Exp Med. 1999 Oct 4;190(7):895-902 19330007 - Nat Med. 2009 Apr;15(4):410-6 22966430 - Pulm Med. 2012;2012:834826 22329990 - J Exp Med. 2012 Mar 12;209(3):607-22 19141733 - J Med Microbiol. 2009 Feb;58(Pt 2):174-9
References_xml	– volume: 23 start-page: 479 year: 2005 ident: ref11 article-title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines publication-title: Immunity doi: 10.1016/j.immuni.2005.09.015 – volume: 123 start-page: 438S year: 2003 ident: ref27 article-title: Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children publication-title: Chest doi: 10.1378/chest.123.3_suppl.438S – volume: 40 start-page: 38 year: 2009 ident: ref25 article-title: Adjuvant and anti-inflammatory properties of cigarette smoke in murine allergic airway inflammation publication-title: Am J Respir Cell Mol Biol doi: 10.1165/rcmb.2008-0107OC – volume: 7 start-page: 224 year: 2008 ident: ref44 article-title: TGF-beta, eosinophils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations publication-title: Inflamm Allergy Drug Targets doi: 10.2174/187152808786848388 – volume: 173 start-page: 1229 year: 2008 ident: ref15 article-title: Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation publication-title: Am J Pathol doi: 10.2353/ajpath.2008.080014 – volume: 276 start-page: L604 year: 1999 ident: ref26 article-title: Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production publication-title: Am J Physiol – volume: 15 start-page: 410 year: 2009 ident: ref21 article-title: House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells publication-title: Nat Med doi: 10.1038/nm.1946 – volume: 190 start-page: 895 year: 1999 ident: ref34 article-title: Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses publication-title: J Exp Med doi: 10.1084/jem.190.7.895 – volume: 102 start-page: 1704 year: 1998 ident: ref6 article-title: GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice publication-title: J Clin Invest doi: 10.1172/JCI4160 – volume: 2012 start-page: 834826 year: 2012 ident: ref24 article-title: Virus infection-induced bronchial asthma exacerbation publication-title: Pulm Med doi: 10.1155/2012/834826 – volume: 12 start-page: 631 year: 2011 ident: ref13 article-title: Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity publication-title: Nat Immunol doi: 10.1038/ni.2045 – volume: 62 start-page: 423 year: 2007 ident: ref28 article-title: Polymorphisms in eosinophil pathway genes, asthma and atopy publication-title: Allergy doi: 10.1111/j.1398-9995.2006.01300.x – volume: 58 start-page: 174 year: 2009 ident: ref23 article-title: Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549 publication-title: J Med Microbiol doi: 10.1099/jmm.0.005488-0 – volume: 284 start-page: 89 year: 1999 ident: ref4 article-title: Complexity in chemistry publication-title: Science doi: 10.1126/science.284.5411.89 – volume: 386 start-page: 181 year: 2009 ident: ref37 article-title: Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.06.008 – volume: 190 start-page: 1541 year: 1999 ident: ref35 article-title: The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function publication-title: J Exp Med doi: 10.1084/jem.190.10.1541 – volume: 280 start-page: L493 year: 2001 ident: ref22 article-title: Proinflammatory cytokine responses to P. aeruginosa infection in human airway epithelial cell lines publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.2001.280.3.L493 – volume: 209 start-page: 1505 year: 2012 ident: ref20 article-title: Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33 publication-title: J Exp Med doi: 10.1084/jem.20112691 – volume: 104 start-page: 282 year: 2007 ident: ref43 article-title: IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0606854104 – volume: 188 start-page: 3488 year: 2012 ident: ref40 article-title: Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain publication-title: J Immunol doi: 10.4049/jimmunol.1101977 – volume: 296 start-page: L1051 year: 2009 ident: ref17 article-title: Characterization of mouse alveolar epithelial cell monolayers publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00021.2009 – volume: 183 start-page: 7890 year: 2009 ident: ref42 article-title: Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages publication-title: J Immunol doi: 10.4049/jimmunol.0802449 – volume: 113 start-page: 157 year: 1998 ident: ref7 article-title: Compartmentalized transgene expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mouse lung enhances allergic airways inflammation publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.1998.00652.x – volume: 207 start-page: 2097 year: 2010 ident: ref30 article-title: Inflammatory dendritic cells–not basophils–are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen publication-title: J Exp Med doi: 10.1084/jem.20101563 – volume: 114 start-page: 1033 year: 2004 ident: ref1 article-title: Geographic variations in the effect of atopy on asthma in the European Community Respiratory Health Study publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2004.05.072 – volume: 125 start-page: 752 year: 2010 ident: ref14 article-title: Increased IL-33 expression by epithelial cells in bronchial asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2009.12.935 – volume: 293 start-page: L730 year: 2007 ident: ref10 article-title: Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00056.2007 – volume: 40 start-page: 200 year: 2010 ident: ref31 article-title: IL-33: a tissue derived cytokine pathway involved in allergic inflammation and asthma publication-title: Clin Exp Allergy doi: 10.1111/j.1365-2222.2009.03384.x – volume: 16 start-page: 510 year: 1997 ident: ref29 article-title: Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation publication-title: Am J Respir Cell Mol Biol doi: 10.1165/ajrcmb.16.5.9160833 – volume: 209 start-page: 607 year: 2012 ident: ref12 article-title: Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection publication-title: J Exp Med doi: 10.1084/jem.20110079 – volume: 183 start-page: 5094 year: 2009 ident: ref18 article-title: Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells publication-title: J Immunol doi: 10.4049/jimmunol.0802387 – volume: 109 start-page: 3451 year: 2012 ident: ref38 article-title: Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1201042109 – ident: ref41 doi: 10.1002/eji.201242863 – volume: 186 start-page: 2372 year: 2011 ident: ref39 article-title: IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina publication-title: J Immunol doi: 10.4049/jimmunol.1002558 – ident: ref5 doi: 10.1002/9781444346688.ch14 – ident: ref9 doi: 10.1016/j.jaci.2012.08.002 – volume: 3 start-page: e3331 year: 2008 ident: ref16 article-title: The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel ‘alarmin’? publication-title: PLoS One doi: 10.1371/journal.pone.0003331 – volume: 20 start-page: 791 year: 2008 ident: ref32 article-title: Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system publication-title: Int Immunol doi: 10.1093/intimm/dxn037 – volume: 3 start-page: e2426 year: 2008 ident: ref3 article-title: In vivo-to-in silico iterations to investigate aeroallergen-host interactions publication-title: PLoS One doi: 10.1371/journal.pone.0002426 – volume: 132 start-page: 2593 year: 2012 ident: ref19 article-title: Regulation of IL-33 expression by IFN-gamma and tumor necrosis factor-alpha in normal human epidermal keratinocytes publication-title: J Invest Dermatol doi: 10.1038/jid.2012.185 – volume: 59 start-page: 469 year: 2004 ident: ref2 article-title: The global burden of asthma: executive summary of the GINA Dissemination Committee report publication-title: Allergy doi: 10.1111/j.1398-9995.2004.00526.x – volume: 131 start-page: 159 year: 2010 ident: ref33 article-title: Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice publication-title: Immunol Lett doi: 10.1016/j.imlet.2010.04.005 – volume: 177 start-page: 593 year: 2008 ident: ref45 article-title: Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200706-958OC – volume: 169 start-page: 378 year: 2004 ident: ref8 article-title: Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200308-1094OC – volume: 191 start-page: 1069 year: 2000 ident: ref36 article-title: T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses publication-title: J Exp Med doi: 10.1084/jem.191.6.1069 – reference: 18545674 - PLoS One. 2008;3(6):e2426 – reference: 22673732 - J Invest Dermatol. 2012 Nov;132(11):2593-600 – reference: 10510079 - J Exp Med. 1999 Oct 4;190(7):895-902 – reference: 10562328 - J Exp Med. 1999 Nov 15;190(10):1541-8 – reference: 10727469 - J Exp Med. 2000 Mar 20;191(6):1069-76 – reference: 9717963 - Clin Exp Immunol. 1998 Aug;113(2):157-65 – reference: 9802884 - J Clin Invest. 1998 Nov 1;102(9):1704-14 – reference: 22371395 - J Immunol. 2012 Apr 1;188(7):3488-95 – reference: 22329990 - J Exp Med. 2012 Mar 12;209(3):607-22 – reference: 18448455 - Int Immunol. 2008 Jun;20(6):791-800 – reference: 10102824 - Science. 1999 Apr 2;284(5411):89-92 – reference: 22966430 - Pulm Med. 2012;2012:834826 – reference: 20412815 - Immunol Lett. 2010 Jul 8;131(2):159-65 – reference: 10198358 - Am J Physiol. 1999 Apr;276(4 Pt 1):L604-13 – reference: 15080825 - Allergy. 2004 May;59(5):469-78 – reference: 17586699 - Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L730-9 – reference: 14597485 - Am J Respir Crit Care Med. 2004 Feb 1;169(3):378-85 – reference: 16286016 - Immunity. 2005 Nov;23(5):479-90 – reference: 19508862 - Biochem Biophys Res Commun. 2009 Aug 14;386(1):181-5 – reference: 21220696 - J Immunol. 2011 Feb 15;186(4):2372-81 – reference: 22802353 - J Exp Med. 2012 Jul 30;209(8):1505-17 – reference: 19906013 - Clin Exp Allergy. 2010 Feb;40(2):200-8 – reference: 21623379 - Nat Immunol. 2011 Jul;12(7):631-8 – reference: 11159033 - Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L493-502 – reference: 12629028 - Chest. 2003 Mar;123(3 Suppl):438S – reference: 17185418 - Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7 – reference: 20153038 - J Allergy Clin Immunol. 2010 Mar;125(3):752-4 – reference: 23169007 - Eur J Immunol. 2013 Feb;43(2):488-98 – reference: 19141733 - J Med Microbiol. 2009 Feb;58(Pt 2):174-9 – reference: 9160833 - Am J Respir Cell Mol Biol. 1997 May;16(5):510-20 – reference: 20819925 - J Exp Med. 2010 Sep 27;207(10):2097-111 – reference: 17362254 - Allergy. 2007 Apr;62(4):423-8 – reference: 19330007 - Nat Med. 2009 Apr;15(4):410-6 – reference: 19329539 - Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L1051-8 – reference: 18174546 - Am J Respir Crit Care Med. 2008 Mar 15;177(6):593-603 – reference: 15536406 - J Allergy Clin Immunol. 2004 Nov;114(5):1033-9 – reference: 18836528 - PLoS One. 2008;3(10):e3331 – reference: 18787100 - Am J Pathol. 2008 Oct;173(4):1229-42 – reference: 23006545 - J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8 – reference: 19933859 - J Immunol. 2009 Dec 15;183(12):7890-7 – reference: 19075788 - Inflamm Allergy Drug Targets. 2008 Dec;7(4):224-36 – reference: 22331917 - Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3451-6 – reference: 18635815 - Am J Respir Cell Mol Biol. 2009 Jan;40(1):38-46 – reference: 19801525 - J Immunol. 2009 Oct 15;183(8):5094-103
SSID	ssj0053866
Score	2.3581502
Snippet	Allergic asthma is a chronic immune-inflammatory disease of the airways. Despite aeroallergen exposure being universal, allergic asthma affects only a fraction...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e88714
SubjectTerms	Allergens Allergies Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - immunology Alveolar Epithelial Cells - pathology Alveoli Analysis Animals Asthma B cells Biology CD11b antigen Cytokines Dust Epithelial cells Exposure Female Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology House dust Humans Hypersensitivity Hypersensitivity - immunology Hypersensitivity - parasitology Immunity - drug effects Immunology Inflammation Inflammation - complications Inflammation - immunology Inflammation - pathology Interleukin-1alpha - metabolism Interleukin-33 Interleukins - metabolism Leukocytes (eosinophilic) Ligands Lung - immunology Lung - parasitology Lung - pathology Lungs Lymphocytes T Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Macrophages, Alveolar - pathology Medicine Mice Mice, Inbred BALB C Mites Models, Immunological Mucus Ox40L protein Pathology Pollutants Pollution control Pyroglyphidae - drug effects Pyroglyphidae - immunology Respiratory tract Time Factors
SummonAdditionalLinks	– databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELegIMQLsPGxwACDkIAH06R2neQJlbGySXRU20B7sxzHHpWmpDQtH_89d4kbFjQBEq-5S5TcnS939t3vCHkmLU-NsYIZ7SBB0VHGdJaGLItcrCORZ4nR9bCJ-OAgOTlJp37DrfJllWufWDvqvDS4R96HSB5xVUTMX8-_MJwahaerfoTGZXIFURJ4Xbo3XXtiWMtS-nY5Hkd9r51X87KwCGua1L07535HNWp_65t787Oyuijw_L1-8twPaXzzfz_lFrnhQ1E6amxng1yyxSa5NvGH7Ztkw6_7ir7w4NQvbxM3ou8mbOdo3N9_zzinU4ggv-kfdKxNg_cN7CNsLwSPSkezBdIOmzpcoCxLCp6KHYMBVXjuRffKVWXp21W1pBN4O7r7fV7inuUd8nG8e7yzx_ysBmYg41iyOANj4C4UTiSRA_M0uTbJUJhcDrE3N5R6GONokyiRWR5mucg4hBaZMXlsEJTxLukVoJctQnMpwa1oqa1GaByhdRoJZ6UIc8ezYRgQvlaZMh7IHOdpnKn6dC6GhKYRoEJFK6_ogLD2rnkD5PEX_jdoDS0vwnDXF8rFqfKrWoWpltJwbVOXitTZNB24nEcWkkRuuBgG5DHakmp6WltnokY4tABih4gH5GnNgVAcBdb6nOpVVan9D5_-genosMP03DO5EsRhtO-vgG9CiK8O53aHExyK6ZC30PLXUqnUL3uFO9cWfTH5SUvGh2L9XmHBkBSkHaFMBvEARHKvWTytZAcConbI8wMSd5ZVR_RdSjH7XCOhQ3AP8Xh8_8-v9YBchzBXYK19JLZJb7lY2Yfkqvm6nFWLR7XL-AnKbXXI priority: 102 providerName: ProQuest – databaseName: Public Library of Science dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELegILQXYONjgQEGIQEPYUnt2vFjGSubtI5qG9PeIsexR6UpqZqWj_-eu8QNZNoEvPbOVXq-u_yuPv-OkNfCMmWM5aHRDgoUHWehzlQUZrGTOuZ5lhhdD5uQh4fJ2Zma_C4UL53gMxlve5u-n5WFRTJSQPj8JrnVZ0JgC9docrDKvBC7Qvjrcdet7Lx-apb-Nhf3ZhdldRXQvNwv-ccLaHTvfx_9PrnroSYdNr6xTm7YYoPcGfvD9A2y7uO6om89-fS7B8QN6adxuHM82t4_CBmjE0CI3_VPOtKm4fMG9SFeH4SMSYfTOcqOmj5bkCxKCpkoPAEHqfBci-6Vy8rSj8tqQccAbunuj1mJ_0k-JF9Guyc7e6GfxRAaqCgWocxgs5mLuONJ7MD9TK5NMuAmFwO8exsJPZA4uiRORJZHWc4zBtAhMyaXBkkXH5FeAWbYJDQXAtKGFtpqpL7hWquYOyt4lDuWDaKAsNUWpcYTleO8jIu0Pn2TULA0BkzRrqm3a0DCdtWsIer4i_4H3P1WF2m26w9gA1MftWmktBCGaauc4spZpfouZ7GFIpAZxgcBeYG-kzZ3VttkkQ5xKAFgg5gF5FWtgVQbBfbynOtlVaX7n0__Qen4qKP0xiu5EsxhtL8_Ab8JKbw6mlsdTUgYpiPeRE9fWaWC6k8hZRGXuHLl_VeLX7Zi_FLszyssOFIKZUUkkr7sg0keN8HSWrbPAZVDHR8Q2Qmjjum7kmL6tWY6B_AOeFs-uf6Jn5I1gLAc--hjvkV6i_nSPiO3zbfFtJo_r9PDL-meZBQ priority: 102 providerName: Public Library of Science
Title	A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure
URI	https://www.ncbi.nlm.nih.gov/pubmed/24551140 https://www.proquest.com/docview/1498237473 https://www.proquest.com/docview/1500682725 https://pubmed.ncbi.nlm.nih.gov/PMC3925157 https://doaj.org/article/09a66c3ae9f949fe992fd31e2603c345 http://dx.doi.org/10.1371/journal.pone.0088714
Volume	9
WOSCitedRecordID	wos000331271500056&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection (Proquest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database (ProQuest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELeg8MALYnytMIpBSMBD1qR27eSxrVaotpaohWnwEjmOzSpNSdW0fPz33CVp1KBJ44GXe-idq_bubN8ld78j5I0wLNDacEcrCwmK8mJHxYHrxJ6VyuNJ7GtVDJuQs5l_cRGEe6O-sCashAcuFdd1AyWEZsoENuCBNUHQswnzDMThTDNeoJdC1LNLpsozGHaxEFWjHJNet7LL8SpLDQKa-kXXzt5FVOD116dya3WV5deFnH9XTu5dReMH5H4VQ9JB-dsPyC2TPiQH1S7N6bsKSvr9I2IH9MPUGS3G3cmZwxjF-cM_1W9qlS7RuUEch6ms4fyjarlG3rqsmgXOJqP5NnY2YO4c31LRy2ybG4qzPii2RVHza5XhE8bH5Mv45PPoo1NNVnA05AcbR8ZgOmZdbrnvWXAmnSjt97lORB87aV2h-hIHkXi-iBM3TnjMIBCItU6kRgjFJ6SVgi4PCU2EgENACWUUAtlwpQKPWyO4m1gW9902YTs1R7qCHcfpF1dR8S5NQvpRai1C40SVcdrEqVetStiNG-SHaMFaFkGziw_AlaLKlaKbXKlNXqL9o7IDtd760QBHDMBN77E2eV1IIHBGipU539U2z6PJp_N_EFrMG0JvKyGbgTq0qroh4D8hIFdD8qghCdtfN9iH6K07reSQywUIQMQlrtx58PXsVzUbvxSr7VIDjhRBkuAKvyd7oJKnpcPXmu1xiLEhK28T2dgKDdU3OenyssAth1Acomf57H_Y6jm5B6Erx_p5jx-R1ma9NS_IXf1js8zXHXJbzs-RXsiC-kD9kdchd4Yns3DeKQ4LoOPwDOjp8Bjo1D1FKsOCLoCG_W-wIpxMw69_ALDpcjs
linkProvider	Directory of Open Access Journals
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VgIAL0PJooNAFgYCDiZ3drO0DQqFtSNSkVGmoejPr9W6JVNkhTij9U_xGZvyiRhVw6YGrd2zZ45lvZ-yZbwh5LjTzldLcUtJAgiKd0JKhb1uhY1zp8Cj0lMyGTbh7e97Rkb-_Qn6UvTBYVlliYgbUUaLwG3kLInnkVeEuezf7auHUKPy7Wo7QyM1iV5-dQsqWvh1sw_t90W73diZbfauYKmApiI0XlhvCbTNjc8M9x4AiVSSV1-EqEh3sIrWF7Lg4hMPxRBjZYcRDBptgqFTkKqQPhOteIVcBxx0sIXPHhyXyA3YIUbTnMddpFdbwZpbEGmlUvaxX6Nz2l00JqPaCxuwkSS8KdH-v1zy3AfZu_2-qu0NuFaE27ea-sUpWdLxGro-KYoI1slrgWkpfFeTbr-8S06UfRtbWQa81GFqM0X2IkE_lGe1JlfOZg3gX2ydhx6Dd6RzXxnmdMawsEgpIbE3AQVL8r0f7yTLVdHuZLugItEF3vs8S_CZ7j3y6lEe_Txox2ME6oZEQAJtSSC2R-odL6TvcaMHtyLCwYzcJK00kUAVRO84LOQmyv48uJGy5AgM0rKAwrCaxqrNmOVHJX-Tfo_VVskgznh1I5sdBgVqB7UshFJPaNz73jfb9tomYoyEJZorxTpNsou0Gec9uBZZBF4cyQGzksCZ5lkkg1UiMtUzHcpmmweDj4T8IHYxrQi8LIZOAOpQs-kfgmZDCrCa5UZMEwFS15XX0tFIrafDLP-DM0oMuXn5aLeNFsT4x1mBIAaRVtvDabhtU8iB31kqzbQ5ZicPhvbo1N66pvr4ST79kTO-QvEC-4T78821tkhv9yWgYDAd7u4_ITQjpOfYVOHyDNBbzpX5Mrqlvi2k6f5LBFSWfL9vJfwLijNRI
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb9MwELdGQRMvwMafFQYzCMR4CE1q10keECrtyqqtpdoG2ltwHHtUmprStIx9NT4dd4kbFjQBL3vgNXeJ4svd-S6--x0hz4VmoVKaO0oaSFCkFzsyDl0n9owvPZ7EgZL5sAl_OAyOj8PRCvmx7IXBssqlT8wddZIq_EfegEgecVW4zxrGlkWMur23068OTpDCk9blOI1CRfb0-Rmkb9mbfhe-9Ytms7dz1Nl17IQBR0GcPHf8GJbAjMsNDzwDQlWJVEGLq0S0sKPUFbLl40AOLxBx4sYJjxlsiLFSia8QShCee41c9xloMXapd8ryEvAjQthWPeZ7DasZr6fpRCOkapD3DV3YCvOJAeW-UJueptllQe_vtZsXNsPe7f9ZjHfILRuC03ZhM2tkRU_WyerAFhmskzXr7zK6bUG5X90lpk3fD5zOYa_R33cYoyOInM_kOe1JVeCcA3sb2yphJ6Ht8QxpB0X9MVDmKQUP7RyB4WR43kd300WmaXeRzekApEF3vk9T_Fd7j3y8kqXfJ7UJ6MQGoYkQ4E6lkFoiJBCXMvS40YK7iWFxy60TtlSXSFkAd5wjchrlp5I-JHKFACNUssgqWZ045V3TAsDkL_zvUBNLXoQfzy-ks5PIerPIDaUQikkdmpCHRodh0yTM05AcM8V4q062UI-jope3dKJRG4c1QMzksTp5lnMgBMkEtfBELrIs6n_49A9MhwcVppeWyaQgDiVtXwmsCaHNKpybFU5wpKpC3kCrW0oli37ZCty5tKbLyU9LMj4U6xYnGhQpgnTLFUHTb4JIHhSGW0q2ySFb8Th8V79i0hXRVymT8ZccAR6SGshD_Id_fq0tsgq2He33h3uPyE2I9Dm2G3h8k9Tms4V-TG6ob_NxNnuSey5KPl-1jf8E_tDcow
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+GM-CSF%2FIL-33+Pathway+Facilitates+Allergic+Airway+Responses+to+Sub-Threshold+House+Dust+Mite+Exposure&rft.jtitle=PloS+one&rft.au=Llop-Guevara%2C+Alba&rft.au=Chu%2C+Derek+K.&rft.au=Walker%2C+Tina+D.&rft.au=Goncharova%2C+Susanna&rft.date=2014-02-14&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=9&rft.issue=2&rft.spage=e88714&rft_id=info:doi/10.1371%2Fjournal.pone.0088714&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0088714
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon