Vitamin D Responsive Elements within the HLA-DRB1 Promoter Region in Sardinian Multiple Sclerosis Associated Alleles

Vitamin D response elements (VDREs) have been found in the promoter region of the MS-associated allele HLA-DRB1*15:01, suggesting that with low vitamin D availability VDREs are incapable of inducing *15:01 expression allowing in early life autoreactive T-cells to escape central thymic deletion. The...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 7; p. e41678
Main Authors:	Cocco, Eleonora, Meloni, Alessandra, Murru, Maria Rita, Corongiu, Daniela, Tranquilli, Stefania, Fadda, Elisabetta, Murru, Raffaele, Schirru, Lucia, Secci, Maria Antonietta, Costa, Gianna, Asunis, Isadora, Cuccu, Stefania, Fenu, Giuseppe, Lorefice, Lorena, Carboni, Nicola, Mura, Gioia, Rosatelli, Maria Cristina, Marrosu, Maria Giovanna
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25.07.2012 Public Library of Science (PLoS)
Subjects:	Adult Alleles Autoimmune diseases Autoimmunity Base Sequence Biology Case-Control Studies Clonal deletion Computational Biology Diabetes Disease susceptibility Drb1 protein Electrophoretic mobility Female Gene expression Genetic Predisposition to Disease - genetics Genomes Haplotypes Histocompatibility antigen HLA HLA antigens HLA-DRB1 Chains - genetics Humans Insulin-like growth factors Italy Lymphocytes T Male Medicine Metabolites Molecular Sequence Data Monoclonal antibodies Multiple sclerosis Multiple Sclerosis - genetics Patients Population Proteins Radiation effects Receptors, Calcitriol - metabolism Regulatory sequences Retinoid X receptors Sequence Analysis, DNA Solar radiation T cells Thymus Transcription Transcriptional Activation - genetics Vitamin D Vitamin D receptors Vitamin D Response Element - genetics Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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