Involvement of Membrane GRP78 in Trophoblastic Cell Fusion

Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated. In this study, we have examined the role of GRP78 in trophoblast fusion using the...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 8; p. e40596
Main Authors:	Fradet, Sarah, Pierredon, Sandra, Ribaux, Pascale, Epiney, Manuella, Shin Ya, Kazuo, Irion, Olivier, Cohen, Marie
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09.08.2012 Public Library of Science (PLoS)
Subjects:	Achievement tests Adult Analysis Antibodies Apoptosis Binding sites Biology Cancer Cell culture Cell Fusion Cell Line, Tumor Cell surface Chemical inhibitors Choriocarcinoma Chorionic Gonadotropin - secretion Colforsin - pharmacology Deregulation Down-Regulation - drug effects Endoplasmic reticulum Female Forskolin Fusion protein Gene expression Glucose Gynecology Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Hypoxia Medicine Membrane fusion Membranes Morphology mRNA Obstetrics Placenta Plasma Pre-eclampsia Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Preeclampsia Pregnancy Pregnancy Trimester, First - genetics Pregnancy Trimester, First - metabolism Proteins Relocation RNA Set-top boxes (Television) siRNA Trophoblasts - cytology Trophoblasts - drug effects Trophoblasts - metabolism Trophoblasts - pathology Switzerland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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