Involvement of Membrane GRP78 in Trophoblastic Cell Fusion
Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated. In this study, we have examined the role of GRP78 in trophoblast fusion using the...
Uloženo v:
| Vydáno v: | PloS one Ročník 7; číslo 8; s. e40596 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
09.08.2012
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated.
In this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs.
Our results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia. |
|---|---|
| AbstractList | Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated.BACKGROUNDGlucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated.In this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs.METHODOLOGY/PRINCIPAL FINDINGSIn this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs.Our results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia.CONCLUSIONSOur results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia. Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated. In this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs. Our results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia. Background Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated. Methodology/Principal Findings In this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs. Conclusions Our results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia. Background Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated. Methodology/Principal Findings In this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs. Conclusions Our results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia. Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the role of GRP78 in these cells has never been investigated. In this study, we have examined the role of GRP78 in trophoblast fusion using the Bewo choriocarcinoma cell line as a model of cytotrophoblast fusion. Down regulation of GRP78 by siRNA or chemical inhibitors and use of antibodies against GRP78 in culture medium significantly decreased forskolin-induced fusion capacity of Bewo cells suggesting the involvement of membrane GRP78 in trophoblast fusion. GRP78 expression was also studied in preeclamptic (PE) CTBs which are known to have lower fusion capacity compared to control CTBs. Interestingly, despite the increase of GRP78 mRNA in PE CTBs, membrane GRP78 is significantly decreased in PE CTBs compared to control CTBs, suggesting that relocation of GRP78 from the endoplasmic reticulum to cell surface is probably altered in PE CTBs. Our results imply that membrane GRP78 could play an important role in syncytialisation. They also suggest that deregulation of GRP78 expression or relocation at cell surface might be involved in pregnancy complication associated with defective syncytialisation, such as preeclampsia. |
| Audience | Academic |
| Author | Ribaux, Pascale Irion, Olivier Epiney, Manuella Fradet, Sarah Shin Ya, Kazuo Cohen, Marie Pierredon, Sandra |
| AuthorAffiliation | 1 Department of Gynecology Obstetrics, Faculty of Medicine, Geneva, Switzerland 2 Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan VU University Medical Center, The Netherlands |
| AuthorAffiliation_xml | – name: 2 Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan – name: 1 Department of Gynecology Obstetrics, Faculty of Medicine, Geneva, Switzerland – name: VU University Medical Center, The Netherlands |
| Author_xml | – sequence: 1 givenname: Sarah surname: Fradet fullname: Fradet, Sarah – sequence: 2 givenname: Sandra surname: Pierredon fullname: Pierredon, Sandra – sequence: 3 givenname: Pascale surname: Ribaux fullname: Ribaux, Pascale – sequence: 4 givenname: Manuella surname: Epiney fullname: Epiney, Manuella – sequence: 5 givenname: Kazuo surname: Shin Ya fullname: Shin Ya, Kazuo – sequence: 6 givenname: Olivier surname: Irion fullname: Irion, Olivier – sequence: 7 givenname: Marie surname: Cohen fullname: Cohen, Marie |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22912664$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk11v0zAUhiM0xD7gHyCIhITgosWOHcfZBdJUsVFpaGgMbi3HsVtXTtzZSQX_nlOaomaaEMqFo-PnvPZ5fc5pctT6VifJS4ymmBT4w8r3oZVuuobwFCGK8pI9SU5wSbIJyxA5Ovg_Tk5jXCGUE87Ys-Q4y0qcMUZPkvN5u_Fuoxvddqk36RfdVEG2Or26_Vrw1LbpXfDrpa-cjJ1V6Uw7l1720fr2efLUSBf1i2E9S75ffrqbfZ5c31zNZxfXE1XkvJsUmLGCosJgTDmhFVMllnVpuCoMB0JphhmlWWEM4pjXFVacm0wSRbiqWE3Oktc73bXzUQxlR4FJxnKMWZEDMd8RtZcrsQ62keGX8NKKPwEfFkIGuL3TokJcEsQN1ySntcQlo0qagipSylKbrdbH4bS-anStwJcg3Uh0vNPapVj4jSAU5xRxEHg3CAR_3-vYicZGBbaBq76HeyNCOQJTKKBvHqCPVzdQCwkF2NZ4OFdtRcVFTgmBh6cZUNNHKPhq3VgFPWIsxEcJ70cJwHT6Z7eQfYxi_u32_9mbH2P27QG71NJ1y-hd30HLxDH46tDpvxbvmxOA8x2ggo8xaCOU7eRWB0qzDpwU20nYmya2kyCGSYBk-iB5r__PtN9ZfQme |
| CitedBy_id | crossref_primary_10_1016_j_canlet_2021_10_004 crossref_primary_10_1016_j_mce_2015_11_010 crossref_primary_10_1016_j_freeradbiomed_2022_08_033 crossref_primary_10_3390_biom12091300 crossref_primary_10_1007_s12079_023_00732_3 crossref_primary_10_1016_j_ejogrb_2025_114728 crossref_primary_10_1038_s41390_023_02501_9 crossref_primary_10_1111_asj_12439 crossref_primary_10_1016_j_placenta_2021_12_006 crossref_primary_10_1007_s00018_022_04475_z crossref_primary_10_1093_molehr_gau113 crossref_primary_10_3389_fendo_2024_1525189 crossref_primary_10_1093_molehr_gat049 crossref_primary_10_1371_journal_pone_0080231 crossref_primary_10_1371_journal_pone_0177994 crossref_primary_10_1002_cbin_10636 crossref_primary_10_1210_en_2017_03039 crossref_primary_10_3389_fcell_2021_648463 crossref_primary_10_1038_s41598_020_66554_0 crossref_primary_10_1038_s41598_021_97799_y crossref_primary_10_1093_biolre_ioaf071 crossref_primary_10_3390_ijms17050638 crossref_primary_10_1186_s12014_021_09324_y crossref_primary_10_1038_s41419_019_1905_6 crossref_primary_10_1111_jth_12570 crossref_primary_10_3389_fendo_2023_1182049 crossref_primary_10_1002_jcla_24802 crossref_primary_10_1186_s12885_022_09648_4 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2012 Public Library of Science Fradet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2012 Fradet et al 2012 Fradet et al |
| Copyright_xml | – notice: COPYRIGHT 2012 Public Library of Science – notice: Fradet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2012 Fradet et al 2012 Fradet et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0040596 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & allied health premium. Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection (UHCL Subscription) Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Materials Science Database (NC LIVE) Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database (Proquest) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine Biology |
| DocumentTitleAlternate | GRP78 and Cell Fusion |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1326511675 oai_doaj_org_article_b08a308f8e354da1964caf74c39a9ef5 PMC3415408 2943635101 A543305942 22912664 10_1371_journal_pone_0040596 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Switzerland |
| GeographicLocations_xml | – name: Switzerland |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF NPM PV9 RZL 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c758t-71667407f114834b6c91ad9f8c7f8758ce6164427ff0818db1c88f2a3c38cb6d3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 34 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000307378500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:29:48 EST 2021 Tue Oct 14 18:49:57 EDT 2025 Tue Nov 04 02:02:39 EST 2025 Sun Sep 28 11:23:54 EDT 2025 Tue Oct 07 06:48:51 EDT 2025 Sat Nov 29 13:15:19 EST 2025 Sat Nov 29 10:01:43 EST 2025 Wed Nov 26 10:12:32 EST 2025 Wed Nov 26 10:10:23 EST 2025 Thu May 22 21:19:51 EDT 2025 Wed Feb 19 01:49:04 EST 2025 Tue Nov 18 22:32:12 EST 2025 Sat Nov 29 02:35:40 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c758t-71667407f114834b6c91ad9f8c7f8758ce6164427ff0818db1c88f2a3c38cb6d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: SF SP PR MC. Performed the experiments: SF SP PR MC. Analyzed the data: SF SP PR MC. Contributed reagents/materials/analysis tools: SF MC. Wrote the paper: SF SP PR MC ME KS OI. Competing Interests: The authors have declared that no competing interests exist. |
| OpenAccessLink | https://doaj.org/article/b08a308f8e354da1964caf74c39a9ef5 |
| PMID | 22912664 |
| PQID | 1326511675 |
| PQPubID | 1436336 |
| PageCount | e40596 |
| ParticipantIDs | plos_journals_1326511675 doaj_primary_oai_doaj_org_article_b08a308f8e354da1964caf74c39a9ef5 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3415408 proquest_miscellaneous_1034801664 proquest_journals_1326511675 gale_infotracmisc_A543305942 gale_infotracacademiconefile_A543305942 gale_incontextgauss_ISR_A543305942 gale_incontextgauss_IOV_A543305942 gale_healthsolutions_A543305942 pubmed_primary_22912664 crossref_citationtrail_10_1371_journal_pone_0040596 crossref_primary_10_1371_journal_pone_0040596 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-08-09 |
| PublicationDateYYYYMMDD | 2012-08-09 |
| PublicationDate_xml | – month: 08 year: 2012 text: 2012-08-09 day: 09 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2012 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | 1838791 - Mol Endocrinol. 1991 Dec;5(12):1862-72 15339968 - J Natl Cancer Inst. 2004 Sep 1;96(17):1300-10 15890698 - J Physiol. 2005 Jul 15;566(Pt 2):409-23 19482905 - Mol Hum Reprod. 2009 Sep;15(9):569-74 19151922 - Cell Mol Life Sci. 2009 May;66(9):1556-69 21493955 - Reprod Sci. 2011 Nov;18(11):1085-91 7679981 - Endocrinology. 1993 Mar;132(3):1387-95 21309747 - Biochem J. 2011 Mar 1;434(2):181-8 12676351 - Biochim Biophys Acta. 2003 Apr 7;1640(1):25-31 10693809 - Nature. 2000 Feb 17;403(6771):785-9 16472112 - Curr Mol Med. 2006 Feb;6(1):45-54 15081634 - Placenta. 2004 May;25(5):396-407 19823030 - Cancer Biol Ther. 2009 Nov;8(22):2103-5 19632185 - Cell. 2009 Jul 23;138(2):377-88 20208072 - J Biol Chem. 2010 May 14;285(20):15065-75 15837062 - Placenta. 2005 Apr;26 Suppl A:S21-30 9363258 - Early Pregnancy. 1995 Dec;1(4):263-9 12757936 - Biochim Biophys Acta. 2003 May 20;1638(1):63-71 20663796 - Hum Reprod. 2010 Sep;25(9):2229-38 16129952 - Chem Immunol Allergy. 2005;89:49-61 8547487 - Biol Reprod. 1995 Oct;53(4):905-10 20036312 - Mol Cell Endocrinol. 2010 Jul 8;323(1):94-104 16861902 - Cancer Biol Ther. 2006 Jul;5(7):741-4 21035520 - Mol Cell Endocrinol. 2011 Jan 30;332(1-2):213-20 15381142 - Int J Biochem Cell Biol. 2005 Jan;37(1):1-16 19331544 - Antioxid Redox Signal. 2009 Sep;11(9):2299-306 15333590 - Hum Reprod Update. 2004 Nov-Dec;10(6):487-96 17546632 - Mol Reprod Dev. 2008 Jan;75(1):175-83 16210392 - Hum Reprod. 2006 Jan;21(1):193-201 9852131 - J Biol Chem. 1998 Dec 18;273(51):34594-602 17068222 - Hum Reprod Update. 2007 Mar-Apr;13(2):121-41 19601892 - Mini Rev Med Chem. 2009 Jul;9(8):962-73 15699139 - J Immunol. 2005 Feb 15;174(4):2092-7 20017148 - Proteomics. 2009 Dec;9(23):5316-27 20970977 - Curr Opin Cell Biol. 2011 Apr;23(2):150-6 2153559 - Exp Cell Res. 1990 Feb;186(2):306-16 |
| References_xml | – reference: 17068222 - Hum Reprod Update. 2007 Mar-Apr;13(2):121-41 – reference: 1838791 - Mol Endocrinol. 1991 Dec;5(12):1862-72 – reference: 9363258 - Early Pregnancy. 1995 Dec;1(4):263-9 – reference: 8547487 - Biol Reprod. 1995 Oct;53(4):905-10 – reference: 16861902 - Cancer Biol Ther. 2006 Jul;5(7):741-4 – reference: 15699139 - J Immunol. 2005 Feb 15;174(4):2092-7 – reference: 19601892 - Mini Rev Med Chem. 2009 Jul;9(8):962-73 – reference: 15081634 - Placenta. 2004 May;25(5):396-407 – reference: 12676351 - Biochim Biophys Acta. 2003 Apr 7;1640(1):25-31 – reference: 15381142 - Int J Biochem Cell Biol. 2005 Jan;37(1):1-16 – reference: 20663796 - Hum Reprod. 2010 Sep;25(9):2229-38 – reference: 16210392 - Hum Reprod. 2006 Jan;21(1):193-201 – reference: 7679981 - Endocrinology. 1993 Mar;132(3):1387-95 – reference: 19632185 - Cell. 2009 Jul 23;138(2):377-88 – reference: 15339968 - J Natl Cancer Inst. 2004 Sep 1;96(17):1300-10 – reference: 16129952 - Chem Immunol Allergy. 2005;89:49-61 – reference: 17546632 - Mol Reprod Dev. 2008 Jan;75(1):175-83 – reference: 20017148 - Proteomics. 2009 Dec;9(23):5316-27 – reference: 16472112 - Curr Mol Med. 2006 Feb;6(1):45-54 – reference: 15837062 - Placenta. 2005 Apr;26 Suppl A:S21-30 – reference: 21309747 - Biochem J. 2011 Mar 1;434(2):181-8 – reference: 21493955 - Reprod Sci. 2011 Nov;18(11):1085-91 – reference: 12757936 - Biochim Biophys Acta. 2003 May 20;1638(1):63-71 – reference: 19823030 - Cancer Biol Ther. 2009 Nov;8(22):2103-5 – reference: 21035520 - Mol Cell Endocrinol. 2011 Jan 30;332(1-2):213-20 – reference: 10693809 - Nature. 2000 Feb 17;403(6771):785-9 – reference: 19151922 - Cell Mol Life Sci. 2009 May;66(9):1556-69 – reference: 2153559 - Exp Cell Res. 1990 Feb;186(2):306-16 – reference: 15890698 - J Physiol. 2005 Jul 15;566(Pt 2):409-23 – reference: 19482905 - Mol Hum Reprod. 2009 Sep;15(9):569-74 – reference: 20208072 - J Biol Chem. 2010 May 14;285(20):15065-75 – reference: 9852131 - J Biol Chem. 1998 Dec 18;273(51):34594-602 – reference: 19331544 - Antioxid Redox Signal. 2009 Sep;11(9):2299-306 – reference: 15333590 - Hum Reprod Update. 2004 Nov-Dec;10(6):487-96 – reference: 20970977 - Curr Opin Cell Biol. 2011 Apr;23(2):150-6 – reference: 20036312 - Mol Cell Endocrinol. 2010 Jul 8;323(1):94-104 |
| SSID | ssj0053866 |
| Score | 2.2379916 |
| Snippet | Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB). However, the... Background Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB).... BACKGROUND: Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB).... Background Glucose-regulated protein 78 (GRP78) is highly expressed in first trimester cytrophoblastic cells (CTBs), especially in syncytiotrophoblast (STB).... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e40596 |
| SubjectTerms | Achievement tests Adult Analysis Antibodies Apoptosis Binding sites Biology Cancer Cell culture Cell Fusion Cell Line, Tumor Cell surface Chemical inhibitors Choriocarcinoma Chorionic Gonadotropin - secretion Colforsin - pharmacology Deregulation Down-Regulation - drug effects Endoplasmic reticulum Female Forskolin Fusion protein Gene expression Glucose Gynecology Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Hypoxia Medicine Membrane fusion Membranes Morphology mRNA Obstetrics Placenta Plasma Pre-eclampsia Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Preeclampsia Pregnancy Pregnancy Trimester, First - genetics Pregnancy Trimester, First - metabolism Proteins Relocation RNA Set-top boxes (Television) siRNA Trophoblasts - cytology Trophoblasts - drug effects Trophoblasts - metabolism Trophoblasts - pathology |
| SummonAdditionalLinks | – databaseName: Advanced Technologies & Aerospace Database dbid: P5Z link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZgQagXoOXRQIGAkIBD2iRO_OCCSsVCDy2rUqqKS-Q4cbvSNgmbXX4_M443NKgCJK7xOErGM-P57PFnQl7SMM5zSCuCXGoNAIXyQBmsEYPplqcyZCbU9rIJfngoTk_lxC24ta6schUTbaAuao1r5DuAmliKmwbpu-Z7gLdG4e6qu0LjOrmBLAnomJP02yoSgy8z5o7LUR7tuNHZbuqq3EbrTZGq_9J0ZFn7-9g8amZ1e1Xi-Xv95KUJaXznf3_lLrntUlF_t7OddXKtrDbIrQO32b5B1p3ft_5rR0795h55u19BQLMk4wu_Nv5BeQF4uyr9j0cTLvxp5R_P6-a8ziErh_f6e-Vs5o-XuCZ3n3wdfzje-xS4-xcCDShiEQCUYhwAn0HMRJOcaRmpQhqhuQGYI3TJAGwlMTcGifGKPNJCmFhRTYXOWUEfkFEFut4kvolTrQzkInHCE8OE5FFkwlylEC4UlcYjdDUMmXbk5HhHxiyzO24cQEqnlAwHL3OD55Gg79V05Bx_kX-PI9zLIrW2fVDPzzLnqVkeCkVDYURJ06RQSFgGn84TTaWSpUk98gztI-vOqfYBIttNE0qR_Sb2yAsrgfQaFdbvnKll22b7n0_-QejL0UDolRMyNahDK3dmAv4JabsGklsDSQgSetC8ida80kqb_bJB6Lmy0qubn_fN-FKsyavKegkyIUXuIcYSjzzsHKLXbBzLKLYtfOAqA9UPW6rpuWU3h7QKUIR49OfPekzWIHWNbSmm3CKjxXxZPiE39Y_FtJ0_tWHgJ_abY9s priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELegIMQLsPGxQoGAkICHjMRO_MHbmChMYqMaA-0tclybVSpJ1bT8_dw5biDTJuC1d4nsy935fvX5Z0JesISWJZQVcamMAYDCRKwd9ojBcitylXCXGH_ZhDg6kqenavIbKJ7bwWcifRNsuruoK7uLPpcrfpVco4xzbOEaTz5tMi_ELufheNxlT_aWH8_S3-XiwWJeNxcVmuf7Jf9YgMa3_3fod8itUGpGe61vbJErttomNw7DZvo22Qpx3USvAvn067vk7UEFCcuTiK-i2kWH9gfg6cpGH44nQkazKjpZ1ouzuoSqG94b7dv5PBqv8T-3e-Tr-P3J_sc43K8QG0AJqxigEhcA6BxiIpaV3KhUT5WTRjiAMdJYDmAqo8I5JL6blqmR0lHNDJOm5FN2nwwqmNoOiRzNjXZQa9BMZI5LJdLUJaXOIR1optyQsI3ZCxPIx_EOjHnhd9QEgJDWKAXaqgi2GpK4e2rRkm_8Rf8dftFOF6mz_Q_wUYoQiUWZSM0S6aRleTbVSEgGQxeZYUor6_IheYr-ULTnULsEUOzlGWPIbkOH5LnXQPqMCvtzvut10xQHn7_9g9KX457Sy6DkajCH0eFMBMwJabl6mqOeJiQB0xPvoPdurNKAjSjPcY8N5jPaePTF4medGF-KPXeVrdegkzDkFuI8G5IHbQB0lqVUpdRLRC80eqbvS6rZmWcvh7IJUIJ8ePmIH5GbUJZS32apRmSwWq7tY3Ld_FzNmuUTH_K_AGPeUiE priority: 102 providerName: Public Library of Science |
| Title | Involvement of Membrane GRP78 in Trophoblastic Cell Fusion |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22912664 https://www.proquest.com/docview/1326511675 https://www.proquest.com/docview/1034801664 https://pubmed.ncbi.nlm.nih.gov/PMC3415408 https://doaj.org/article/b08a308f8e354da1964caf74c39a9ef5 http://dx.doi.org/10.1371/journal.pone.0040596 |
| Volume | 7 |
| WOSCitedRecordID | wos000307378500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database (Proquest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & allied health premium. customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Materials Science Database (NC LIVE) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF5B4MAFUV4NhGAQEnBwau_a--DWVA1EpcFKoUq5WPbGSyO1dhQn_H5m1o4Vo0rlwGUOmbEVfzuzO2PPfkvIO-bRNIW0wk2V1lCgMOEmBnvEYLkVofK48bQ9bEJMJnI2U9HOUV_YE1bRA1fAHaSeTJgnjcxYGMwT5I_SiRGBZipRmbHspZD1bIupag6GKOa83ijHhH9Qj8tgWeTZAP02RJL-nYXI8vU3s3JneVWUN6Wcf3dO7ixFo0fkYZ1DOofVf98jd7L8Mdmro7R0PtRU0h-fkE_jHKYfSwm-dgrjXGfXUB3nmfN5GgnpLHJnvSqWl0UKOTTczMHX-I7Z4Bu0p-TH6Pj70Re3Pi3B1ZDzr10ofLiA8sxghcOClGvlJ3NlpBYGihKpMw6lUUCFMUhjN099LaWhCdNM6pTP2TPSyQGffeIYGgLGkDnQQASGSyV833hpEkJwJ0yZLmFb6GJdU4njiRZXsf0-JqCkqJCIEfC4BrxL3OaqZUWlcYv9EEelsUUibPsDuEdcu0d8m3t0yWsc07jaVdqEc3wYBowhVw3tkrfWAskwcuy2-ZVsyjIefzv_B6OzacvofW1kCoBDJ_UOB3gmJNlqWfZalhDSuqXeRw_colICRpSH-MUMnqe39cqb1W8aNd4UO-jyrNiAjceQKYjzoEueV07cIEup8qnViJZ7t6Bva_LFpeUihyQIcn754n-M1UvyANJRatsrVY901qtN9orc17_Xi3LVJ3fF9BzlTFgpQcojv0_uDY8n0bRvJwCQo-gryJPhAOSpd4JSRFaegYzCn3BFND6NLv4AaAFgLQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3fb9MwELZGQcALsPFjhcECAsEesiV2YjtICI1BWbW1m0aH-hYSN94qlaQ0LYh_ir-Ru8QJC5qAlz3wGl-i5Hx3vi8-f0fIU-bQOIa0wo4DpQCgMGFHGmvEYLkVfuBw7aii2YTo9-VwGBwukR_VWRgsq6xiYhGoR5nCf-RbgJq4j5sG_uvpFxu7RuHuatVCozSLveT7N4Bs-avuW5jfZ5R23g12dm3TVcBWkBvPbQAIXACM0YgEmBdzFbjRKNBSCQ3Ju1QJBwjhUaE10r2NYldJqWnEFJMq5iMGz71ELkMcF1hCJoY1wIPYwbk5nseEu2WsYXOapckmeouPrQHOLH9Fl4B6LWhNJ1l-XqL7e73mmQWwc_N_U90tcsOk2tZ26RvLZClJV8jVnikmWCHLJq7l1gtDvr1xm7zsphCwCxL1uZVpq5d8jmE5T6z3R4dCWuPUGsyy6WkWA-qA51o7yWRidRb4z_EOOb6Qz7lLWinM7SqxNPVVpCHXop7wNJeBcF3txJEP4TBigW4TVk17qAz5OvYAmYTFjqIAEFYqJURjCY2xtIld3zUtyUf-Iv8GLaqWRerw4kI2OwlNJApjR0bMkVomzPdGERKywasLT7EgChLtt8k62mNYnsOtA2C47XuMIbsPbZMnhQTSh6RYn3QSLfI87B58_AehD0cNoedGSGegDhWZMyHwTUhL1pBca0hCEFSN4VX0nkorefjL5uHOyivOH35cD-NDseYwTbIFyDgMuZU499rkXumAtWYpDVxajIiGazZU3xxJx6cFezukjYCS5P0_v9Y6ubY76O2H-93-3gNyHdJ0WpSdBmukNZ8tkofkivo6H-ezR0UIssini3bcn1_Bvxs |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3fb9MwELZGQRMvwMaPFQYLCMR4yJrYie0gITQ2CtVYqcZAEy8hceKtUklK04L41_jruEucsKAJeNkDr_HFSi535_vi83eEPGQOjWNIK-w4UAoAChN2pLFGDJZb4QcO144qm02I4VAeHQWjJfKjPguDZZV1TCwDdZIr_EfeA9TEfdw08HvalEWMdvvPp19s7CCFO611O43KRPbS798AvhXPBrvwrR9R2n95uPPaNh0GbAV58twGsMAFQBqNqIB5MVeBGyWBlkpoSOSlSjnACY8KrZH6LYldJaWmEVNMqpgnDOa9QC4KwJgI_Eb-x3oVgDjCuTmqx4TbM5axNc2zdAs9x8c2AaeWwrJjQLMudKaTvDgr6f29dvPUYti_-j-r8Rq5YlJwa7vymRWylGarZHnfFBmskhUT7wpr05ByP7lOng4yCOQlufrcyrW1n36OYZlPrVcHIyGtcWYdzvLpSR4DGoF5rZ10MrH6C_wXeYO8P5fXuUk6GXznNWJp6qtIQw5GPeFpLgPhutqJIx_CZMQC3SWsNoFQGVJ27A0yCcudRgHgrFJKiIYTGsPpEru5a1qRkvxF_gVaVyOLlOLlhXx2HJoIFcaOjJgjtUyZ7yURErXBowtPsSAKUu13yQbaZlidz20CY7jte4wh6w_tkgelBNKKZGhZx9GiKMLB2w__IPTuoCX02AjpHNShInNWBN4J6cpakustSQiOqjW8hp5Ua6UIf9k_3Fl7yNnD95thnBRrEbM0X4CMw5BziXOvS25VztholtLApeWIaLlpS_XtkWx8UrK6QzoJ6Ene_vNjbZBl8NfwzWC4d4dchuydltWowTrpzGeL9C65pL7Ox8XsXhmNLPLpvP32J2bsyA4 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Involvement+of+Membrane+GRP78+in+Trophoblastic+Cell+Fusion&rft.jtitle=PloS+one&rft.au=Fradet%2C+Sarah&rft.au=Pierredon%2C+Sandra&rft.au=Ribaux%2C+Pascale&rft.au=Epiney%2C+Manuella&rft.date=2012-08-09&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=7&rft.issue=8&rft.spage=e40596&rft_id=info:doi/10.1371%2Fjournal.pone.0040596&rft.externalDBID=IOV&rft.externalDocID=A543305942 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |