Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming

The Library of Integrated Network-Based Cellular Signatures (LINCS) project aims to create a network-based understanding of biology by cataloging changes in gene expression and signal transduction that occur when cells are exposed to a variety of perturbations. It is helpful for understanding cell p...

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Veröffentlicht in:	PloS one Jg. 9; H. 7; S. e102798
Hauptverfasser:	Ji, Zhiwei, Su, Jing, Liu, Chenglin, Wang, Hongyan, Huang, Deshuang, Zhou, Xiaobo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 18.07.2014 Public Library of Science (PLoS)
Schlagworte:	Antineoplastic Agents - pharmacology Benzamides - pharmacology Bioinformatics Biology Biology and Life Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cancer therapies Cell activation Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Line, Tumor Cellular communication Cellular signal transduction Computer and Information Sciences Computer applications Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - metabolism Digoxigenin Digoxigenin - pharmacology Drug discovery Female Gene expression Gene Expression - drug effects Gene Expression - genetics Gene Regulatory Networks - drug effects Gene Regulatory Networks - genetics Genomics Genomics - methods Histone deacetylase Histone Deacetylase Inhibitors - pharmacology HL-60 Cells Humans Hydroxamic Acids - pharmacology Kinases Linear programming MCF-7 Cells Medicine Medicine and Health Sciences Ordinary differential equations p53 Protein Phosphorylation Phosphorylation - drug effects Phosphorylation - genetics Physical Sciences Programming, Linear Prostate cancer Proteins Proteome - metabolism Proteomics Proteomics - methods Pyridines - pharmacology Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Staurosporine Staurosporine - pharmacology Topology Trichostatin A Tumor proteins Tumor Suppressor Protein p53 - metabolism North Carolina United States > US China
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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