The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)

Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-ε4 allele has long been associated with increased risks of Alzheimer's disease and mortality, but the effect of the less prevalent APOE-ε2 allele on diseases in the elderly and surv...

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Bibliographic Details
Published in:	PloS one Vol. 14; no. 7; p. e0219668
Main Authors:	Wolters, Frank J., Yang, Qiong, Biggs, Mary L., Jakobsdottir, Johanna, Li, Shuo, Evans, Daniel S., Bis, Joshua C., Harris, Tamara B., Vasan, Ramachandran S., Zilhao, Nuno R., Ghanbari, Mohsen, Ikram, M. Arfan, Launer, Lenore, Psaty, Bruce M., Tranah, Gregory J., Kulminski, Alexander M., Gudnason, Vilmundur, Seshadri, Sudha
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.07.2019 Public Library of Science (PLoS)
Subjects:	Age Aged Aging Alleles Alzheimer's disease Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Biology and Life Sciences Biometrics Cancer Cardiovascular diseases Carriers Cohort analysis Cohort Studies Confidence intervals Dementia disorders Demography Disease Epidemiology Family studies Female Genomes Genotype Genotype & phenotype Genotypes Geriatrics Glycoproteins Health care Health risks Heart Heterozygote Humans Laboratories Lipids Lipids - blood Low density lipoprotein Male Medical research Medicine and Health Sciences Meta-analysis Meta-Analysis as Topic Mortality Mortality risk Neurodegenerative diseases Patient outcomes People and Places Population Population studies Population-based studies Preventive medicine Public health Research and Analysis Methods Risk Risk factors Studies Survival Survival Analysis Systematic review San Francisco California Netherlands United States > US Massachusetts California Maryland Iceland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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