Loss of the Nuclear Receptor Corepressor SLIRP Compromises Male Fertility

Nuclear receptors (NRs) and their coregulators play fundamental roles in initiating and directing gene expression influencing mammalian reproduction, development and metabolism. SRA stem Loop Interacting RNA-binding Protein (SLIRP) is a Steroid receptor RNA Activator (SRA) RNA-binding protein that i...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 8; p. e70700
Main Authors:	Colley, Shane M., Wintle, Larissa, Searles, Richelle, Russell, Victoria, Firman, Renee C., Smith, Stephanie, DeBoer, Kathleen, Merriner, D. Jo, Genevieve, Ben, Bentel, Jacqueline M., Stuckey, Bronwyn G. A., Phillips, Michael R., Simmons, Leigh W., de Kretser, David M., O'Bryan, Moira K., Leedman, Peter J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15.08.2013 Public Library of Science (PLoS)
Subjects:	Animals Asthenozoospermia - genetics Asthenozoospermia - metabolism Asthenozoospermia - pathology Biology Cancer Cell Nucleus - genetics Cell Nucleus - metabolism Developmental biology Electron microscopy Evolutionary biology Female Females Fertility Gene expression Gene Expression Regulation Genes Genetic aspects Homozygote Hormones In vivo methods and tests Infertility Laboratories Litter Size Localization Male Males Medical research Medicine Metabolism Mice Mice, Knockout Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - ultrastructure Morphology Motility mRNA turnover Nuclear receptors Nuclei Pharmacology Physiological aspects Protein binding Protein turnover Proteins Receptors Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Rodents Signal Transduction Sperm Spermatogenesis Spermatozoa - metabolism Spermatozoa - ultrastructure Testis - metabolism Testis - pathology Transcription Transcription, Genetic Australia Perth Western Australia Australia
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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