Mechanisms of NK Cell-Macrophage Bacillus anthracis Crosstalk: A Balance between Stimulation by Spores and Differential Disruption by Toxins

NK cells are important immune effectors for preventing microbial invasion and dissemination, through natural cytotoxicity and cytokine secretion. Bacillus anthracis spores can efficiently drive IFN-γ production by NK cells. The present study provides insights into the mechanisms of cytokine and cell...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 8; no. 1; p. e1002481
Main Authors:	Klezovich-Bénard, Maria, Corre, Jean-Philippe, Jusforgues-Saklani, Hélène, Fiole, Daniel, Burjek, Nick, Tournier, Jean-Nicolas, Goossens, Pierre L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.01.2012 Public Library of Science (PLoS)
Subjects:	Animals Bacillus anthracis Bacillus anthracis - immunology Bacterial infections Bacterial Toxins - pharmacology Biology Bordetella pertussis Cell interaction Cells Cells, Cultured Cytotoxicity Edema Female Homeostasis - drug effects Homeostasis - immunology Immune system Immunity, Cellular - drug effects Immunity, Cellular - immunology Immunology Infections Killer cells Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Macrophage Activation - drug effects Macrophage Activation - immunology Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Physiological aspects Proteins Receptor Cross-Talk - drug effects Receptor Cross-Talk - immunology Spores (Bacteria) Spores, Bacterial - immunology Spores, Bacterial - physiology Toxins France
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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