Maternal cardiovascular and endothelial function from first trimester to postpartum

To explore noninvasively the complex interactions of the maternal hemodynamic system throughout pregnancy and the resulting after-effect six weeks postpartum. Eighteen women were tested beginning at the 12th week of gestation at six time-points throughout pregnancy and six weeks postpartum. Heart ra...

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Vydáno v:PloS one Ročník 13; číslo 5; s. e0197748
Hlavní autoři: Kolovetsiou-Kreiner, Vassiliki, Moertl, Manfred Georg, Papousek, Ilona, Schmid-Zalaudek, Karin, Lang, Uwe, Schlembach, Dietmar, Cervar-Zivkovic, Mila, Lackner, Helmut Karl
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 21.05.2018
Public Library of Science (PLoS)
Témata:
Adult
Analysis
Arginine - analogs & derivatives
Arginine - metabolism
Autonomic nervous system
Baroreceptors
Baroreflex
Biology and Life Sciences
Blood
Blood Pressure
Blood pressure regulation
Blood volume
Cardiovascular Physiological Phenomena
Endothelin 1
Endothelin-1 - metabolism
Endothelium
Endothelium - physiology
Female
Gestation
Gynecology
Health aspects
Heart Rate
Hemodynamics
Hemoglobin
Hemoglobins - metabolism
Humans
Loewi, Otto (1873-1961)
Medicine and Health Sciences
Nervous system
Nitric oxide
Obstetrics
Perfusion
Physiology
Postpartum
Postpartum Period - physiology
Preeclampsia
Pregnancy
Pregnancy Trimesters - physiology
Pressoreceptors - metabolism
Prospective Studies
Reflexes
Research and Analysis Methods
Sensitivity
Sensitivity analysis
Transit time
Vagus nerve
Womens health
Austria
ISSN:1932-6203, 1932-6203
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Popis
Shrnutí:To explore noninvasively the complex interactions of the maternal hemodynamic system throughout pregnancy and the resulting after-effect six weeks postpartum. Eighteen women were tested beginning at the 12th week of gestation at six time-points throughout pregnancy and six weeks postpartum. Heart rate, heart rate variability, blood pressure, pulse transit time (PTT), respiration, and baroreceptor sensitivity were analyzed in resting conditions. Additionally, hemoglobin, asymmetric and symmetric dimethylarginine and Endothelin (ET-1) were obtained. Heart rate and sympathovagal balance favoring sympathetic drive increased, the vagal tone and the baroreflex sensitivity decreased during pregnancy. Relative sympathetic drive (sympathovagal balance) reached a maximum at 6 weeks postpartum whereas the other variables did not differ compared to first trimester levels. Postpartum diastolic blood pressure was higher compared to first and second trimester. Pulse transit time and endothelial markers showed no difference throughout gestation. However, opposing variables PTT and asymmetric dimethylarginine (ADMA) were both higher six weeks postpartum. The sympathetic up regulation throughout pregnancy goes hand in hand with a decreased baroreflex sensitivity. In the postpartum period, the autonomic nervous system, biochemical endothelial reactions and PTT show significant and opposing changes compared to pregnancy findings, indicating the complex aftermath of the increase of blood volume, the changes in perfusion strategies and blood pressure regulation that occur in pregnancy.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0197748