Transcriptional Attenuation Controls Macrolide Inducible Efflux and Resistance in Streptococcus pneumoniae and in Other Gram-Positive Bacteria Containing mef/mel(msr(D)) Elements

Macrolide resistance, emerging in Streptococcus pneumoniae and other Gram-positive bacteria, is increasingly due to efflux pumps encoded by mef/mel(msr) operons found on discrete mobile genetic elements. The regulation of mef/mel(msr) in these elements is not well understood. We identified the mef(E...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 2; p. e0116254
Main Authors:	Chancey, Scott T., Bai, Xianhe, Kumar, Nikhil, Drabek, Elliott F., Daugherty, Sean C., Colon, Thomas, Ott, Sandra, Sengamalay, Naomi, Sadzewicz, Lisa, Tallon, Luke J., Fraser, Claire M., Tettelin, Hervé, Stephens, David S.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19.02.2015 Public Library of Science (PLoS)
Subjects:	Anti-Bacterial Agents - pharmacology Antibiotics Attenuation Bacteria Bacterial infections Chromosomes Efflux Gene expression Genetic aspects Genomes Gram-positive bacteria Gram-Positive Bacteria - drug effects Guanine Infectious diseases Laboratories Laws, regulations and rules Macrolides - pharmacology Medicine Microbial drug resistance Microbial Sensitivity Tests mRNA stability Operons Pathogenesis Pneumonia Protein sorting signals Protein structure Purines Regulatory mechanisms (biology) Ribonucleic acid RNA Secondary structure Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pyogenes Streptococcus pyogenes - drug effects Transcription Transcription (Genetics) Veterans Atlanta Georgia Georgia United States > US Maryland Baltimore Maryland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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