STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients. In cancer patients, skeletal muscle wasting, weight loss and mortality are all positively associated with increased serum cytokines, particularly Interleukin-6 (IL-6...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 7; p. e22538
Main Authors:	Bonetto, Andrea, Aydogdu, Tufan, Kunzevitzky, Noelia, Guttridge, Denis C., Khuri, Sawsan, Koniaris, Leonidas G., Zimmers, Teresa A.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 20.07.2011 Public Library of Science (PLoS)
Subjects:	Activation Acute phase proteins Acute phase substances Acute-Phase Reaction - blood Acute-Phase Reaction - etiology Acute-Phase Reaction - genetics Acute-Phase Reaction - metabolism Amino acids Amyloid Anatomy & physiology Animals Apoptosis Biology Burns Cachexia Cachexia - blood Cachexia - complications Cachexia - genetics Cachexia - metabolism Cancer Cancer treatment Cell Line, Tumor Chemical synthesis Coagulation Colon Colonic Neoplasms - complications Cytokines Cytokines - blood Female Fibrin Fibrinogen Gene expression Gene Expression Regulation, Neoplastic Genes Hepatocytes Humans Illnesses Immune response Immune system Innate immunity Insulin Interleukin 6 Interleukins Kinases Liver Liver - metabolism Liver - pathology Localization MAP kinase Medicine Metabolism Mice Mortality Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Musculoskeletal system Myotubes Nutrition Patients Physiology Proteasomes Proteins Proteolysis Quality of life Quantitation RNA Rodents Signaling Skeletal muscle Stat3 protein STAT3 Transcription Factor - metabolism Surgery Transcriptome Tumor necrosis factor-TNF Tumors Weight control Weight loss Florida United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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