The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the me...

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Vydáno v:Thrombosis and haemostasis Ročník 102; číslo 5; s. 874
Hlavní autoři: Rudd, Timothy R, Skidmore, Mark A, Guimond, Scott E, Holman, Joseph, Turnbull, Jeremy E, Lauder, Robert M, Fernig, David G, Yates, Edwin A
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany 01.11.2009
Témata:
Animals
Anticoagulants - chemistry
Anticoagulants - isolation & purification
Cattle
Circular Dichroism
Drug Monitoring - methods
Factor Analysis, Statistical
Glycosaminoglycans - chemistry
Heparin, Low-Molecular-Weight - chemistry
Heparin, Low-Molecular-Weight - isolation & purification
Heparinoids - chemistry
Heparinoids - classification
Heparinoids - isolation & purification
Molecular Structure
Multivariate Analysis
Principal Component Analysis
Swine
ISSN:0340-6245, 2567-689X, 2567-689X
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Popis
Shrnutí:The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0340-6245
2567-689X
2567-689X
DOI:10.1160/TH08-12-0797