Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found...

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Vydané v:	Nature genetics Ročník 50; číslo 4; s. 524 - 537
Hlavní autori:	Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Giese, Anne-Katrin, van der Laan, Sander W., Gretarsdottir, Solveig, Anderson, Christopher D., Almgren, Peter, Amouyel, Philippe, Bartz, Traci M., Benavente, Oscar R., Boncoraglio, Giorgio B., Butterworth, Adam S., Carrera, Caty, Chasman, Daniel I., Cotlarciuc, Ioana, Cruchaga, Carlos, de Bakker, Paul I. W., Duan, Qing, Gottesman, Rebecca F., Harris, Tamara B., Hassan, Ahamad, Havulinna, Aki S., Heckbert, Susan R., Hyacinth, Hyacinth I., Ikram, M. Arfan, Ingelsson, Erik, Jian, Xueqiu, Jukema, J. Wouter, Kanai, Masahiro, Keene, Keith L., Kissela, Brett M., Kleindorfer, Dawn O., Kooperberg, Charles, Lange, Leslie A., Langenberg, Claudia, Launer, Lenore J., Lemmens, Robin, Lewis, Cathryn M., Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K., Meschia, James F., Mitchell, Braxton D., Mosley, Thomas H., Nalls, Michael A., O’Donnell, Martin J., Pulit, Sara L., Reiner, Alexander P., Ridker, Paul M., Rothwell, Peter M., Rotter, Jerome I., Sale, Michele M., Salomaa, Veikko, Sapkota, Bishwa R., Schmidt, Reinhold, Schmidt, Carsten O., Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L. M., Tanislav, Christian, Thijs, Vincent N. S., Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Wareham, Nicholas J., Wassertheil-Smoller, Sylvia, Wilson, James G., Pastinen, Tomi, Ruusalepp, Arno, Koplev, Simon, Björkegren, Johan L. M., Codoni, Veronica, Civelek, Mete, Christophersen, Ingrid E., Roselli, Carolina, Ellinor, Patrick T., Kato, Norihiro, van der Harst, Pim, Elliott, Paul, Takeuchi, Fumihiko, Johnson, Andrew D., Sanghera, Dharambir K., Melander, Olle, Strbian, Daniel, Fernandez-Cadenas, Israel, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Pare, Guillaume, Hopewell, Jemma C., Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B., Seshadri, Sudha, Markus, Hugh S., Debette, Stephanie, Dichgans, Martin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.04.2018 Nature Publishing Group
Predmet:	631/208 631/208/205/2138 692/699/375/534 Agriculture Animal Genetics and Genomics Asian people atrial-fibrillation Basic Medicine Bioinformatics Biomedical and Life Sciences Biomedicine Blood pressure Cancer Research Cardiovascular disease complex traits Computational Biology Consortia coronary-artery-disease Databases, Genetic Epigenesis, Genetic Etiology Female Gene Function Gene Regulatory Networks Genes Genetic diversity Genetic Loci Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Health risks hemorrhagic stroke human genetic-variation Human Genetics Humans INDEL Mutation ischemic-stroke Life Sciences Linkage Disequilibrium Loci Male Medical and Health Sciences Medical Genetics and Genomics Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Meta-analysis Models, Genetic Neurosciences Neurovetenskaper Pleiotropy Polymorphism, Single Nucleotide Regression analysis Risk Risk Factors small-vessel disease Stroke Stroke - classification Stroke - genetics Stroke - physiopathology sudden cardiac death susceptibility Thromboembolism white-matter hyperintensities
ISSN:	1061-4036, 1546-1718, 1546-1718
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