Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents

Aims/hypothesis The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ...

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Vydané v:	Diabetologia Ročník 56; číslo 8; s. 1735 - 1742
Hlavní autori:	Jonsdottir, B., Andersson, C., Carlsson, A., Delli, A., Forsander, G., Ludvigsson, J., Marcus, C., Samuelsson, U., Örtqvist, E., Lernmark, Å., Ivarsson, S.-A., Larsson, H. Elding
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2013 Springer Springer Nature B.V
Predmet:	Adolescent Autoantibodies - immunology Autoimmune thyroid diseases Autoimmunity - genetics Autoimmunity - immunology Biological and medical sciences Child Child, Preschool Clinical Medicine Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinology and Diabetes Endocrinopathies Endokrinologi och diabetes Etiopathogenesis. Screening. Investigations. Target tissue resistance Female GAD65 autoantibodies Genotype Genotype & phenotype Haplotypes HLA genotype HLA-DQ Antigens - immunology Hospitals Human Physiology Humans IA-2 autoantibodies Infant Insulin Insulin autoantibodies Internal Medicine Investigations Klinisk medicin Male Medical and Health Sciences Medical sciences MEDICIN Medicin och hälsovetenskap MEDICINE Medicine & Public Health Metabolic Diseases Non tumoral diseases. Target tissue resistance. Benign neoplasms Pediatrics Proteins Teenagers Thyroglobulin antibodies Thyroid diseases Thyroid Gland - immunology Thyroid peroxidase antibodies Thyroid. Thyroid axis (diseases) Type 1 diabetes ZnT8 autoantibodies Sweden Thyroid peroxidase antibodies Thyroglobulin antibodies Type 1 diabetes Diabetes mellitus IA-2 autoantibodies Autoimmune thyroid diseases HLA genotype Insulin autoantibodies ZnT8 autoantibodies GAD65 autoantibodies Endocrinopathy Autoimmunity HLA-System Pancreatic hormone Endocrine gland Autoimmune disease Thyroid gland Peroxidase Child Human Immunopathology Enzyme Antibody Thyroid diseases Autoantibody Genotype Insulin Peroxidases Thyroglobulin Adolescent Thyroid hormone Oxidoreductases
ISSN:	0012-186X, 1432-0428, 1432-0428
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Shrnutí:	Aims/hypothesis The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ genes. Methods Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analysed for TPOAb and TGAb in addition to autoantibodies against arginine zinc transporter 8 (ZnT8RA), tryptophan zinc transporter 8 (ZnT8WA), glutamine zinc transporter 8 (ZnT8QA), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), HLA-DQA-B1 genotypes, thyroid-stimulating hormone (TSH) and free thyroxine (T4). Results At type 1 diabetes diagnosis, 12% of the children had thyroid autoantibodies (60% were girls; p < 0.0001). GADA was positively associated with TPOAb ( p < 0.001) and with TGAb ( p < 0.001). In addition, ZnT8A was associated with both TPOAb ( p = 0.039) and TGAb ( p = 0.015). DQB105:01 in any genotype was negatively associated with TPOAb (OR 0.55, 95% CI 0.37, 0.83, p value corrected for multiple comparisons ( p c ) = 0.012) and possibly with TGAb (OR 0.55, 95% CI 0.35, 0.87, p c = 0.07). Thyroid autoimmunity in children newly diagnosed with type 1 diabetes was rarely (0.45%) associated with onset of clinical thyroid disease based on TSH and free T4. Conclusions/interpretation GADA and ZnT8A increased the risk for thyroid autoimmunity at the time of clinical diagnosis of type 1 diabetes, while HLA-DQB105:01 reduced the risk. However, the associations between thyroid autoimmunity and HLA-DQ genotype were weak and did not fully explain the co-occurrence of islet and thyroid autoimmunity.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0012-186X 1432-0428 1432-0428
DOI:	10.1007/s00125-013-2934-9