Multi-color reflectance imaging of middle ear pathology in vivo
Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry Jg. 407; H. 12; S. 3277 - 3283 |
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01.05.2015
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| Abstract | Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we employ a modified otoscope with multi-color imaging capabilities for superior characterization of the middle ear constituents in vivo and for enhanced diagnosis of acute otitis media and cholesteatoma. In this pilot study, five patients undergoing surgery for tympanostomy tube placement and congenital cholesteatoma excision were imaged using the custom-designed multi-color video-rate reflectance imaging system. We show that the multi-color imaging approach offers an increase in image contrast, thereby enabling clear visualization of the middle ear constituents, especially of the tympanic membrane vascularity. Differential absorption at the multiple wavelengths provides a measure of biochemical and morphological information, and the rapid acquisition and analysis of these images aids in objective evaluation of the middle ear pathology. Our pilot study shows the potential of using label-free narrow-band reflectance imaging to differentiate middle ear pathological conditions from normal middle ear. This technique can aid in obtaining objective and reproducible diagnoses as well as provide assistance in guiding excisional procedures. |
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| AbstractList | Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we employ a modified otoscope with multi-color imaging capabilities for superior characterization of the middle ear constituents in vivo and for enhanced diagnosis of acute otitis media and cholesteatoma. In this pilot study, five patients undergoing surgery for tympanostomy tube placement and congenital cholesteatoma excision were imaged using the custom-designed multi-color video-rate reflectance imaging system. We show that the multi-color imaging approach offers an increase in image contrast, thereby enabling clear visualization of the middle ear constituents, especially of the tympanic membrane vascularity. Differential absorption at the multiple wavelengths provides a measure of biochemical and morphological information, and the rapid acquisition and analysis of these images aids in objective evaluation of the middle ear pathology. Our pilot study shows the potential of using label-free narrow-band reflectance imaging to differentiate middle ear pathological conditions from normal middle ear. This technique can aid in obtaining objective and reproducible diagnoses as well as provide assistance in guiding excisional procedures. Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we employ a modified otoscope with multi-color imaging capabilities for superior characterization of the middle ear constituents in vivo and for enhanced diagnosis of acute otitis media and cholesteatoma. In this pilot study, five patients undergoing surgery for tympanostomy tube placement and congenital cholesteatoma excision were imaged using the custom-designed multi-color video-rate reflectance imaging system. We show that the multi-color imaging approach offers an increase in image contrast, thereby enabling clear visualization of the middle ear constituents, especially of the tympanic membrane vascularity. Differential absorption at the multiple wavelengths provides a measure of biochemical and morphological information, and the rapid acquisition and analysis of these images aids in objective evaluation of the middle ear pathology. Our pilot study shows the potential of using label-free narrow-band reflectance imaging to differentiate middle ear pathological conditions from normal middle ear. This technique can aid in obtaining objective and reproducible diagnoses as well as provide assistance in guiding excisional procedures. Electronic supplementary material The online version of this article (doi:10.1007/s00216-015-8580-y) contains supplementary material, which is available to authorized users. Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we employ a modified otoscope with multi-color imaging capabilities for superior characterization of the middle ear constituents in vivo and for enhanced diagnosis of acute otitis media and cholesteatoma. In this pilot study, five patients undergoing surgery for tympanostomy tube placement and congenital cholesteatoma excision were imaged using the custom-designed multi-color video-rate reflectance imaging system. We show that the multi-color imaging approach offers an increase in image contrast, thereby enabling clear visualization of the middle ear constituents, especially of the tympanic membrane vascularity. Differential absorption at the multiple wavelengths provides a measure of biochemical and morphological information, and the rapid acquisition and analysis of these images aids in objective evaluation of the middle ear pathology. Our pilot study shows the potential of using label-free narrow-band reflectance imaging to differentiate middle ear pathological conditions from normal middle ear. This technique can aid in obtaining objective and reproducible diagnoses as well as provide assistance in guiding excisional procedures.Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we employ a modified otoscope with multi-color imaging capabilities for superior characterization of the middle ear constituents in vivo and for enhanced diagnosis of acute otitis media and cholesteatoma. In this pilot study, five patients undergoing surgery for tympanostomy tube placement and congenital cholesteatoma excision were imaged using the custom-designed multi-color video-rate reflectance imaging system. We show that the multi-color imaging approach offers an increase in image contrast, thereby enabling clear visualization of the middle ear constituents, especially of the tympanic membrane vascularity. Differential absorption at the multiple wavelengths provides a measure of biochemical and morphological information, and the rapid acquisition and analysis of these images aids in objective evaluation of the middle ear pathology. Our pilot study shows the potential of using label-free narrow-band reflectance imaging to differentiate middle ear pathological conditions from normal middle ear. This technique can aid in obtaining objective and reproducible diagnoses as well as provide assistance in guiding excisional procedures. Issue Title: ABC Spotlight on effect-directed analysis - dose instead of concentration/Surface-enhanced Raman spectroscopy used for prostate cancer detection/Vibrational algorithms for quantitative crystallographic analysis of biomaterials/Quantitative assessment of lipid unsaturation by Raman microscopy Otoscopic examination using white-light illumination has remained virtually unchanged for well over a century. However, the limited contrast of white-light otoscopy constrains the ability to make accurate assessment of middle ear pathology and is subject to significant observer variability. Here, we employ a modified otoscope with multi-color imaging capabilities for superior characterization of the middle ear constituents in vivo and for enhanced diagnosis of acute otitis media and cholesteatoma. In this pilot study, five patients undergoing surgery for tympanostomy tube placement and congenital cholesteatoma excision were imaged using the custom-designed multi-color video-rate reflectance imaging system. We show that the multi-color imaging approach offers an increase in image contrast, thereby enabling clear visualization of the middle ear constituents, especially of the tympanic membrane vascularity. Differential absorption at the multiple wavelengths provides a measure of biochemical and morphological information, and the rapid acquisition and analysis of these images aids in objective evaluation of the middle ear pathology. Our pilot study shows the potential of using label-free narrow-band reflectance imaging to differentiate middle ear pathological conditions from normal middle ear. This technique can aid in obtaining objective and reproducible diagnoses as well as provide assistance in guiding excisional procedures. |
| Audience | Academic |
| Author | Longo, Kaitlyn Pandey, Rishikesh Peterson, Donald Grindle, Christopher Barman, Ishan Valdez, Tulio A. Spegazzini, Nicolas |
| Author_xml | – sequence: 1 givenname: Tulio A. surname: Valdez fullname: Valdez, Tulio A. email: tvaldez@connecticutchildrens.org organization: Department of Pediatric Otolaryngology, Connecticut Children’s Medical Center – sequence: 2 givenname: Nicolas surname: Spegazzini fullname: Spegazzini, Nicolas organization: G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology – sequence: 3 givenname: Rishikesh surname: Pandey fullname: Pandey, Rishikesh organization: G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology – sequence: 4 givenname: Kaitlyn surname: Longo fullname: Longo, Kaitlyn organization: Biodynamics Laboratory, University of Connecticut Health Center – sequence: 5 givenname: Christopher surname: Grindle fullname: Grindle, Christopher organization: Department of Pediatric Otolaryngology, Connecticut Children’s Medical Center – sequence: 6 givenname: Donald surname: Peterson fullname: Peterson, Donald organization: Biodynamics Laboratory, University of Connecticut Health Center – sequence: 7 givenname: Ishan surname: Barman fullname: Barman, Ishan email: ibarman@jhu.edu organization: Department of Mechanical Engineering and Oncology, Johns Hopkins University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25753015$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1155_2020_6219845 crossref_primary_10_1016_j_measurement_2024_114488 crossref_primary_10_1007_s00216_017_0713_z crossref_primary_10_3390_bioengineering11020104 crossref_primary_10_1038_s41598_021_91736_9 crossref_primary_10_3390_diagnostics12040917 crossref_primary_10_1073_pnas_1610529113 crossref_primary_10_1177_0194599816658290 crossref_primary_10_1002_jbio_201700259 crossref_primary_10_1038_srep13305 crossref_primary_10_1016_j_ijporl_2019_109833 crossref_primary_10_1007_s00405_021_07045_4 crossref_primary_10_1016_j_neunet_2020_03_023 crossref_primary_10_1177_0194599818809337 crossref_primary_10_1016_j_anl_2021_03_018 |
| Cites_doi | 10.1117/1.2904658 10.1097/INF.0b013e318179a2ac 10.1002/lary.23344 10.1542/peds.112.6.1379 10.1097/00006454-199409000-00002 10.1016/j.ijporl.2004.09.012 10.1016/j.ijporl.2004.10.013 10.1093/fampra/16.3.262 |
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| Copyright | Springer-Verlag Berlin Heidelberg 2015 COPYRIGHT 2015 Springer |
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| References_xml | – reference: PonkaDBaddarFCan Fam Physician201258976 – reference: PichicheroMECaseyJRPediatr Infect Dis J20082795896210.1097/INF.0b013e318179a2ac – reference: Tjon Pian GiREHalmosGBvan HemelBMvan den HeuvelERvan der LaanBFPlaatBEDikkersFGLaryngoscope20121221826183010.1002/lary.23344 – reference: RoblyerDRichards-KortumRSokolovKEl-NaggarAKWilliamsMDKurachiCGillenwaterAMJ Biomed Opt20081302401910.1117/1.2904658 – reference: TakataGSChanLSMorphewTMangione-SmithRMortonSCShekellePPediatrics20031121379138710.1542/peds.112.6.1379 – reference: JensenPMLousJFam Pract19991626226810.1093/fampra/16.3.2621:STN:280:DyaK1MzmvVymsQ%3D%3D – reference: PichicheroMEPooleMDInt J Pediatr Otorhinolaryngol20056936136610.1016/j.ijporl.2004.10.013 – reference: BlomgrenKPitkarantaAInt J Pediatr Otorhinolaryngol20056929529910.1016/j.ijporl.2004.09.012 – reference: NiemelMUhariMJounio-ErvastiKLuotonenJAlhoOPVierimaaEPediatr Infect Dis J19941376576810.1097/00006454-199409000-00002 – volume: 13 start-page: 024019 year: 2008 ident: 8580_CR6 publication-title: J Biomed Opt doi: 10.1117/1.2904658 – volume: 27 start-page: 958 year: 2008 ident: 8580_CR3 publication-title: Pediatr Infect Dis J doi: 10.1097/INF.0b013e318179a2ac – volume: 122 start-page: 1826 year: 2012 ident: 8580_CR8 publication-title: Laryngoscope doi: 10.1002/lary.23344 – volume: 112 start-page: 1379 year: 2003 ident: 8580_CR4 publication-title: Pediatrics doi: 10.1542/peds.112.6.1379 – volume: 13 start-page: 765 year: 1994 ident: 8580_CR9 publication-title: Pediatr Infect Dis J doi: 10.1097/00006454-199409000-00002 – volume: 69 start-page: 295 year: 2005 ident: 8580_CR1 publication-title: Int J Pediatr Otorhinolaryngol doi: 10.1016/j.ijporl.2004.09.012 – volume: 69 start-page: 361 year: 2005 ident: 8580_CR5 publication-title: Int J Pediatr Otorhinolaryngol doi: 10.1016/j.ijporl.2004.10.013 – volume: 58 start-page: 976 year: 2012 ident: 8580_CR7 publication-title: Can Fam Physician – volume: 16 start-page: 262 year: 1999 ident: 8580_CR2 publication-title: Fam Pract doi: 10.1093/fampra/16.3.262 – reference: 15733595 - Int J Pediatr Otorhinolaryngol. 2005 Mar;69(3):361-6 – reference: 18465982 - J Biomed Opt. 2008 Mar-Apr;13(2):024019 – reference: 10439980 - Fam Pract. 1999 Jun;16(3):262-8 – reference: 18845985 - Pediatr Infect Dis J. 2008 Nov;27(11):958-62 – reference: 22972730 - Can Fam Physician. 2012 Sep;58(9):976 – reference: 15733586 - Int J Pediatr Otorhinolaryngol. 2005 Mar;69(3):295-9 – reference: 22566012 - Laryngoscope. 2012 Aug;122(8):1826-30 – reference: 7808842 - Pediatr Infect Dis J. 1994 Sep;13(9):765-8 – reference: 14654613 - Pediatrics. 2003 Dec;112(6 Pt 1):1379-87 |
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