Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells

Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1(MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on...

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Bibliographic Details
Published in:	Journal of Pharmacological Sciences Vol. 100; no. 2; pp. 162 - 166
Main Authors:	Shokawa, Tomoki, Yoshizumi, Masao, Yamamoto, Hideya, Omura, Shinji, Toyofuku, Mamoru, Shimizu, Yoshito, Imazu, Michinori, Kohno, Nobuoki
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Pharmacological Society 2006 Elsevier
Subjects:	Chemokine CCL2 - antagonists & inhibitors Chemokine CCL2 - genetics Dose-Response Relationship, Drug Enzyme Induction Gene Expression Regulation - drug effects Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics Humans Lysophosphatidylcholines - pharmacology Monocytes - cytology Monocytes - drug effects Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism RNA, Ribosomal, 18S - metabolism Time Factors U937 Cells
ISSN:	1347-8613
Online Access:	Get full text
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