Bioaccumulation of therapeutic drugs by human gut bacteria

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently 1 and the main underlying mechanism proposed is the chemical transformation of drugs by microorganisms (biotra...

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Veröffentlicht in:	Nature (London) Jg. 597; H. 7877; S. 533 - 538
Hauptverfasser:	Klünemann, Martina, Andrejev, Sergej, Blasche, Sonja, Mateus, Andre, Phapale, Prasad, Devendran, Saravanan, Vappiani, Johanna, Simon, Bernd, Scott, Timothy A., Kafkia, Eleni, Konstantinidis, Dimitrios, Zirngibl, Katharina, Mastrorilli, Eleonora, Banzhaf, Manuel, Mackmull, Marie-Therese, Hövelmann, Felix, Nesme, Leo, Brochado, Ana Rita, Maier, Lisa, Bock, Thomas, Periwal, Vinita, Kumar, Manjeet, Kim, Yongkyu, Tramontano, Melanie, Schultz, Carsten, Beck, Martin, Hennig, Janosch, Zimmermann, Michael, Sévin, Daniel C., Cabreiro, Filipe, Savitski, Mikhail M., Bork, Peer, Typas, Athanasios, Patil, Kiran R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 23.09.2021 Nature Publishing Group
Schlagworte:	631/326/2565/2134 631/553/2710 64/11 82/58 Accumulators Animal models Animals Antidepressants Antidepressive Agents - metabolism Antidepressive Agents - pharmacokinetics Availability Bacteria Bacteria - metabolism Bioaccumulation Biosynthesis Biotransformation Caenorhabditis elegans - metabolism Cells - metabolism Chemical synthesis Chemistry Chromatography Click Chemistry Composition effects Depletion Drug interactions Drug metabolism Duloxetine Duloxetine Hydrochloride - adverse effects Duloxetine Hydrochloride - metabolism Duloxetine Hydrochloride - pharmacokinetics E coli Enzymes Gastrointestinal Microbiome - physiology Humanities and Social Sciences Humans Metabolism Metabolites Metabolomics Microbiota Microbiota (Symbiotic organisms) Microorganisms Models, Animal multidisciplinary NMR Nuclear magnetic resonance Pharmacokinetics Pharmacology, Experimental Physiological aspects Proteins Proteomes Proteomics Reproducibility of Results Science Science (multidisciplinary) Side effects Syntrophism Germany
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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