Oncogenically active MYD88 mutations in human lymphoma

MYD88 signalling in cancer RNA interference screening and high-throughput RNA resequencing have been used to reveal oncogenic mutations in the signalling adapter MYD88 in human lymphomas. One amino acid substitution, L265P, was found in 29% of biopsies from patients with the activated B-cell-like su...

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Veröffentlicht in:	Nature (London) Jg. 470; H. 7332; S. 115 - 119
Hauptverfasser:	Ngo, Vu N., Young, Ryan M., Schmitz, Roland, Jhavar, Sameer, Xiao, Wenming, Lim, Kian-Huat, Kohlhammer, Holger, Xu, Weihong, Yang, Yandan, Zhao, Hong, Shaffer, Arthur L., Romesser, Paul, Wright, George, Powell, John, Rosenwald, Andreas, Muller-Hermelink, Hans Konrad, Ott, German, Gascoyne, Randy D., Connors, Joseph M., Rimsza, Lisa M., Campo, Elias, Jaffe, Elaine S., Delabie, Jan, Smeland, Erlend B., Fisher, Richard I., Braziel, Rita M., Tubbs, Raymond R., Cook, J. R., Weisenburger, Denny D., Chan, Wing C., Staudt, Louis M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 03.02.2011 Nature Publishing Group
Schlagworte:	631/208/737 631/250/516 692/420/755 692/699/67/1990/291/1621/1915 Abnormalities Amino Acid Sequence Amino Acid Substitution Amino acids Apoptosis Biological and medical sciences Burkitt Lymphoma - genetics Cell Line, Tumor Cell Survival Cytokines - metabolism Cytokines - secretion Gene mutations Genetic aspects Hematologic and hematopoietic diseases High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Hydrophobic and Hydrophilic Interactions Interleukin-1 Receptor-Associated Kinases - biosynthesis Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Janus Kinases - metabolism Kinases letter Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, B-Cell, Marginal Zone - genetics Lymphoma, Large B-Cell, Diffuse - classification Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - pathology Lymphomas Medical sciences Molecular Sequence Data multidisciplinary Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Mutation - genetics Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism Observations Oncogenes - genetics Phosphorylation Protein Structure, Tertiary Receptors, Interleukin-1 - metabolism RNA Interference Science Science (multidisciplinary) Sequence Analysis, RNA Signal Transduction STAT3 Transcription Factor - metabolism Survival Toll-Like Receptors - metabolism Toxicity Tumors United States Human MyD88 adaptor protein Enzyme Transferases Clinical form Malignant hemopathy Non Hodgkin lymphoma Carcinogenesis Signal transduction Gene Kinase Lymphoproliferative syndrome Genetics Diffuse large B cell lymphoma Mutation Subtype Cancer
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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