New gene functions in megakaryopoiesis and platelet formation

Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a...

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Published in:	Nature (London) Vol. 480; no. 7376; pp. 201 - 208
Main Authors:	Gieger, Christian, Radhakrishnan, Aparna, Cvejic, Ana, Tang, Weihong, Pistis, Giorgio, Serbanovic-Canic, Jovana, Elling, Ulrich, Goodall, Alison H., Labrune, Yann, Lopez, Lorna M., Meacham, Stuart, Sorice, Rossella, Teumer, Alexander, Ramirez-Solis, Ramiro, Ellinghaus, David, Gögele, Martin, Hottenga, Jouke-Jan, Langenberg, Claudia, Kovacs, Peter, O’Reilly, Paul F., Shin, So-Youn, Murgia, Federico, Parsa, Afshin, Stephens, Jonathan, Ellen van der Schoot, C., Allayee, Hooman, Attwood, Antony, Baumeister, Sebastian E., Biino, Ginevra, Cambien, François, Cucca, Francesco, de Boer, Rudolf A., Erdmann, Jeanette, Evans, David M., Falchi, Mario, Feng, Wei, Folsom, Aaron R., Frazer, Ian H., Gibson, Quince D., Glazer, Nicole L., Hartikainen, Anna-Liisa, Heckbert, Susan R., Hersch, Micha, Illig, Thomas, Kühnel, Brigitte, Lagou, Vasiliki, Lloyd-Jones, Heather, Lumley, Thomas, Maschio, Andrea, Mateo Leach, Irene, McKnight, Barbara, Memari, Yasin, Montgomery, Grant W., Nakamura, Yusuke, Nauck, Matthias, Nöthlings, Ute, Nolte, Ilja M., Pouta, Anneli, Ruggiero, Daniela, Sala, Cinzia, Sambrook, Jennifer, Schlessinger, David, Scott, James, Smith, Nicholas L., Snieder, Harold, Starr, John M., Stumvoll, Michael, Wilson Tang, W. H., Tenesa, Albert, Uda, Manuela, Visscher, Peter M., Völker, Uwe, Willemsen, Gonneke, Yang, Tsun-Po, Zitting, Paavo, Dedoussis, George V., Metspalu, Andres, Shuldiner, Alan R., Joost van Pelt, L., Zwaginga, Jaap-Jan, Franke, Andre, Froguel, Philippe, Jarvelin, Marjo-Riitta, Martin, Nicholas G., Meisinger, Christa, Psaty, Bruce M., Spector, Timothy D., Wareham, Nicholas J., Akkerman, Jan-Willem N., Ciullo, Marina, Deloukas, Panos, Jupe, Steve, Khadake, Jyoti, Kooner, Jaspal S., Penninger, Josef, Stemple, Derek, Wernisch, Lorenz, Sanna, Serena, Rendon, Augusto, Soranzo, Nicole
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2011 Nature Publishing Group
Subjects:	631/136/232/2051/1339 631/208/191/2018 631/208/205/2138 631/337/475/2290 Animals Biological and medical sciences Blood platelets Blood Platelets - cytology Blood Platelets - metabolism Cell Size Drosophila melanogaster - genetics Drosophila Proteins - genetics Europe Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Silencing Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Genome, Human - genetics Genome-Wide Association Study Genomes Heart attacks Hematopoiesis - genetics Hemostasis Human Humanities and Social Sciences Humans Megakaryocytes - cytology Megakaryocytes - metabolism Methods multidisciplinary Mutation Platelet Count Population genetics, reproduction patterns Protein Interaction Maps Quality control Science Science (multidisciplinary) Studies Transcription, Genetic - genetics Zebrafish - genetics Zebrafish Proteins - genetics Europe Germany Human Megakaryocytopoiesis Platelet Gene Hemostasis Population genetics
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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