The shifting role of the cerebellum in executive, emotional and social processing across the lifespan

The cerebellum’s anatomical and functional organization and network interactions between the cerebellum and the cerebral cortex and subcortical structures are dynamic across the lifespan. Executive, emotional and social (EES) functions have likewise evolved during human development from contributing...

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Veröffentlicht in:Behavioral and brain functions Jg. 18; H. 1; S. 6 - 11
Hauptverfasser: Beuriat, Pierre-Aurélien, Cristofori, Irene, Gordon, Barry, Grafman, Jordan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 28.04.2022
Springer Nature B.V
BMC
Schlagworte:
Adult
Adults
Behavior
Behavioral Therapy
Biomedical and Life Sciences
Biomedicine
Brain
Cerebellum
Cerebellum - diagnostic imaging
Cerebral Cortex
Child
Child, Preschool
Children
Cognition & reasoning
Cognitive ability
Computational neuroscience
Emotion
Emotions
Executive functions
Functional morphology
Humans
Hypothalamus
Hypothesis
Infant, Newborn
Life Sciences
Life span
Longevity
Memory
Motor task performance
Neonates
Neural networks
Neuroimaging
Neurology
Neurosciences
Patients
Psychiatry
Social behaviors
Volunteers
Cerebellum
Executive functions
Adults
Emotion
Children
Social behaviors
ISSN:1744-9081, 1744-9081
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Zusammenfassung:The cerebellum’s anatomical and functional organization and network interactions between the cerebellum and the cerebral cortex and subcortical structures are dynamic across the lifespan. Executive, emotional and social (EES) functions have likewise evolved during human development from contributing to primitive behaviors during infancy and childhood to being able to modulate complex actions in adults. In this review, we address how the importance of the cerebellum in the processing of EES functions might change across development. This evolution is driven by the macroscopic and microscopic modifications of the cerebellum that are occurring during development including its increasing connectivity with distant supra-tentorial cortical and sub-cortical regions. As a result of anatomical and functional changes, neuroimaging and clinical data indicate that the importance of the role of the cerebellum in human EES-related networks shifts from being crucial in newborns and young children to being only supportive later in life. In early life, given the immaturity of cortically mediated EES functions, EES functions and motor control and perception are more closely interrelated. At that time, the cerebellum due to its important role in motor control and sequencing makes EES functions more reliant on these computational properties that compute spatial distance, motor intent, and assist in the execution of sequences of behavior related to their developing EES expression. As the cortical brain matures, EES functions and decisions become less dependent upon these aspects of motor behavior and more dependent upon high-order cognitive and social conceptual processes. At that time, the cerebellum assumes a supportive role in these EES-related behaviors by computing their motor and sequential features. We suspect that this evolving role of the cerebellum has complicated the interpretation of its contribution to EES computational demands.
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ISSN:1744-9081
1744-9081
DOI:10.1186/s12993-022-00193-5