Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently, metformin was reported to alter the gut microbiota community in humans, suggesting that the hyperglycemia-lowering actio...

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Veröffentlicht in:	Nature medicine Jg. 24; H. 12; S. 1919 - 1929
Hauptverfasser:	Sun, Lulu, Xie, Cen, Wang, Guang, Wu, Yue, Wu, Qing, Wang, Xuemei, Liu, Jia, Deng, Yangyang, Xia, Jialin, Chen, Bo, Zhang, Songyang, Yun, Chuyu, Lian, Guan, Zhang, Xiujuan, Zhang, Heng, Bisson, William H., Shi, Jingmin, Gao, Xiaoxia, Ge, Pupu, Liu, Cuihua, Krausz, Kristopher W., Nichols, Robert G., Cai, Jingwei, Rimal, Bipin, Patterson, Andrew D., Wang, Xian, Gonzalez, Frank J., Jiang, Changtao
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.12.2018 Nature Publishing Group
Schlagworte:	631/154/555 631/326/41/2142 692/163/2743/137 692/699/317 Antidiabetics Bacteroides - drug effects Bacteroides - pathogenicity Bile acids Bile Acids and Salts - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Deoxycholic acid Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - microbiology Diabetes Mellitus, Type 2 - pathology Diet, High-Fat - adverse effects Digestive system Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Gastrointestinal tract Gene Expression Regulation, Bacterial - drug effects Gluconeogenesis Glucose Glucose intolerance Glucose Intolerance - drug therapy Glucose Intolerance - genetics Glucose Intolerance - microbiology Glucose tolerance Hepatocytes High fat diet Humans Hyperglycemia Hyperglycemia - drug therapy Hyperglycemia - genetics Hyperglycemia - microbiology Hyperglycemia - pathology Hypoglycemic agents Infectious Diseases Intestinal microflora Intestine Intolerance Metabolic Diseases Metabolism Metabolites Metabolome - drug effects Metabolome - genetics Metabolomics Metagenomics - methods Metformin Metformin - administration & dosage Mice Microbiota Microbiota (Symbiotic organisms) Microorganisms Molecular Medicine Neurosciences Obesity - drug therapy Obesity - genetics Obesity - microbiology Obesity - pathology Receptors, Cytoplasmic and Nuclear - genetics Retirement benefits Signaling Type 2 diabetes Ursodeoxycholic Acid - analogs & derivatives
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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