IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, c...
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| Veröffentlicht in: | The World Allergy Organization journal Jg. 13; H. 2; S. 100080 |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Elsevier Inc
01.02.2020
Elsevier BV Elsevier World Allergy Organization |
| Schlagworte: | |
| ISSN: | 1939-4551, 1939-4551 |
| Online-Zugang: | Volltext |
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| Abstract | Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. |
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| AbstractList | Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both and . It discusses skin tests, challenges, and serological and cellular tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen. Keywords: IgE, Allergy, In vitro tests, Skin tests, Diagnostic strategies |
| ArticleNumber | 100080 |
| Author | DuBuske, Lawrence M. Cardona, Victoria Poulsen, Lars K. Romano, Antonino G. Kalpaklioğlu, Ayse Füsun Demoly, Pascal M. Pawankar, Ruby Ebisawa, Motohiro Sisul, Juan Carlos Jares, Edgardo Renz, Harald E. Passalacqua, Giovanni Savi, Eleonora Jensen-Jarolim, Erika Gerth van Wijk, Roy Canonica, Giorgio Walter Ferrer Puga, Marta Wood, Robert A. González Díaz, Sandra Nora Luengo Sánchez, Olga Pfaar, Oliver Ledford, Dennis K. Rosário Filho, Nelson A. Rosenwasser, Lanny Haahtela, Tari Fischer, David A. Kase Tanno, Luciana Zuberbier, Torsten Tang, Mimi L.K. Caraballo, Luis Thong, Bernard Yu-Hor Antila, Martti Gómez, R. Maximiliano Valenta, Rudolf Sánchez Borges, Mario A. Ansotegui, Ignacio J. Chiang, Wen Chin Monge Ortega, Olga Patricia Ebo, Didier Morais Almeida, Mário Kowalski, Marek L. Senna, Gian-Enrico Scala, Enrico Melioli, Giovanni Villa, Elisa Gonzalez-Estrada, Alexei Bousquet, Jean J. Oppenheimer, John J. |
| AuthorAffiliation | k Allergy Section, Department of Internal Medicine, Vall d’Hebron University Hospital, Barcelona, Spain ar University of Missouri at Kansas City, School of Medicine, Kansas City, MO, USA ag Hospital Sírio Libanês, University of São Paulo, São Paulo, Brazil h Ospedale Civile, Gossolengo, PC, Italy i Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital, Antwerp University, Department Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium e Azienda Sanitaria Locale di Vercelli, S.C. Pneumologia, Vercelli, Italia s Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France r INSERM, Villejuif, France ao University Hospital GI & MR GmbH, Institute of Laboratory Medicine & Pathology, Standort Marburg, Marburg, Germany t Euforea, Brussels, Belgium l Pulmonary & Allergy Associates, Denville, NJ, USA n Fischer Medicine Professional Corporation, Barrie, Ontario, Canada j Universidad Católica de Salta, Fundación Ayre, Buenos Aires, Argentina g Allergy a |
| AuthorAffiliation_xml | – name: d Institute for Immunological Research, University of Cartagena, Cartagena, Colombia – name: ao University Hospital GI & MR GmbH, Institute of Laboratory Medicine & Pathology, Standort Marburg, Marburg, Germany – name: w Mount Elizabeth Medical Centre, Chiang Children's Allergy & Asthma Clinic, Singapore, Singapore – name: av Allergy & Asthma Institute, Asunción, Paraguay – name: ay Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria – name: t Euforea, Brussels, Belgium – name: z Immunology Research Institute of New England, Gardner, MA, USA – name: aw Royal Children's Hospital, Department of Allergy & Immunology, Parkville, Victoria, Australia – name: an Nippon Medical School, Dept. of Otolaryngology, Tokyo, Japan – name: at Experimental Allergy Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy – name: c Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy – name: r INSERM, Villejuif, France – name: aq University of Parana, Curitiba, PR, Brazil – name: u CHU Montpellier, France – name: aa The Unidad de Educación Médica, Department of Medical Education, School of Medicine, Clinica Universitad de Navarra, Navarra, Spain – name: ah Faculty of Medicine, Department of Clinical Immunology & Allergy, Medical University of Łódź, Łódź, Poland – name: f Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan – name: j Universidad Católica de Salta, Fundación Ayre, Buenos Aires, Argentina – name: v Universitat Autónoma de Barcelona, Hospital Universitario Vall d'Hebron, Servicio de Medicina Interna, Sección de Alergología, Barcelona, Spain – name: ag Hospital Sírio Libanês, University of São Paulo, São Paulo, Brazil – name: ax Tan Tock Seng Hospital, Deptartment of Rheumatology, Allergy & Immunology, Singapore, Singapore – name: ac Universidad Autónoma de Nuevo León, Hospital Universitario, Monterrey, Nuevo León, Mexico – name: ar University of Missouri at Kansas City, School of Medicine, Kansas City, MO, USA – name: h Ospedale Civile, Gossolengo, PC, Italy – name: y Sorbonne Université, Paris, France – name: p Clínica de Alergía, Sorocaba, São Paulo, Brazil – name: as Centro Médico Docente La Trinidad, Caracas, Venezuela – name: b Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy – name: ap Stallergenes, Rome, Italy – name: aj Allergology Unit, San Juan de Dios Hospital, University of Costa Rica, San José, Costa Rica – name: al Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany – name: n Fischer Medicine Professional Corporation, Barrie, Ontario, Canada – name: ae Femeca Femedica, Buenos Aires, Argentina – name: ak Hospital CUF-Descobertas, Lisbon, Portugal – name: ba Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia – name: e Azienda Sanitaria Locale di Vercelli, S.C. Pneumologia, Vercelli, Italia – name: k Allergy Section, Department of Internal Medicine, Vall d’Hebron University Hospital, Barcelona, Spain – name: a Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain – name: i Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital, Antwerp University, Department Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium – name: o Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland – name: ab Erasmus MC, Sector Allergologie, Rotterdam, the Netherlands – name: bc Campus Charite Mitte, Klinik fur Dermatologie & Allergologie, Berlin, Germany – name: x University Hospital Montpellier, Montpellier, France – name: ai University of South Florida College of Medicine, Tampa, FL, USA – name: s Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France – name: g Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy – name: q MACVIA-France, Montpellier, France – name: m Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, Vienna, Austria – name: l Pulmonary & Allergy Associates, Denville, NJ, USA – name: au Ospedale Civile Maggiore, Verona, Italy – name: bb Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA – name: ad Department of Allergy, Mayo Clinic, Jacksonville, FL, USA – name: az NRC Institute of Immunology FMBA of Russia, Moscow, Russia – name: af Kirikkale Universitesi, Tip Fakultesi, Kirikkale, Turkey – name: am Gentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, Denmark |
| Author_xml | – sequence: 1 givenname: Ignacio J. surname: Ansotegui fullname: Ansotegui, Ignacio J. email: ignacioansotegui@gmail.com organization: Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain – sequence: 2 givenname: Giovanni surname: Melioli fullname: Melioli, Giovanni organization: Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy – sequence: 3 givenname: Giorgio Walter surname: Canonica fullname: Canonica, Giorgio Walter organization: Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy – sequence: 4 givenname: Luis surname: Caraballo fullname: Caraballo, Luis organization: Institute for Immunological Research, University of Cartagena, Cartagena, Colombia – sequence: 5 givenname: Elisa surname: Villa fullname: Villa, Elisa organization: Azienda Sanitaria Locale di Vercelli, S.C. Pneumologia, Vercelli, Italia – sequence: 6 givenname: Motohiro surname: Ebisawa fullname: Ebisawa, Motohiro organization: Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan – sequence: 7 givenname: Giovanni surname: Passalacqua fullname: Passalacqua, Giovanni organization: Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy – sequence: 8 givenname: Eleonora surname: Savi fullname: Savi, Eleonora organization: Ospedale Civile, Gossolengo, PC, Italy – sequence: 9 givenname: Didier surname: Ebo fullname: Ebo, Didier organization: Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital, Antwerp University, Department Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium – sequence: 10 givenname: R. Maximiliano surname: Gómez fullname: Gómez, R. Maximiliano organization: Universidad Católica de Salta, Fundación Ayre, Buenos Aires, Argentina – sequence: 11 givenname: Olga surname: Luengo Sánchez fullname: Luengo Sánchez, Olga organization: Allergy Section, Department of Internal Medicine, Vall d’Hebron University Hospital, Barcelona, Spain – sequence: 12 givenname: John J. surname: Oppenheimer fullname: Oppenheimer, John J. organization: Pulmonary & Allergy Associates, Denville, NJ, USA – sequence: 13 givenname: Erika surname: Jensen-Jarolim fullname: Jensen-Jarolim, Erika organization: Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, Vienna, Austria – sequence: 14 givenname: David A. surname: Fischer fullname: Fischer, David A. organization: Fischer Medicine Professional Corporation, Barrie, Ontario, Canada – sequence: 15 givenname: Tari surname: Haahtela fullname: Haahtela, Tari organization: Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland – sequence: 16 givenname: Martti surname: Antila fullname: Antila, Martti organization: Clínica de Alergía, Sorocaba, São Paulo, Brazil – sequence: 17 givenname: Jean J. surname: Bousquet fullname: Bousquet, Jean J. organization: MACVIA-France, Montpellier, France – sequence: 18 givenname: Victoria surname: Cardona fullname: Cardona, Victoria organization: Universitat Autónoma de Barcelona, Hospital Universitario Vall d'Hebron, Servicio de Medicina Interna, Sección de Alergología, Barcelona, Spain – sequence: 19 givenname: Wen Chin surname: Chiang fullname: Chiang, Wen Chin organization: Mount Elizabeth Medical Centre, Chiang Children's Allergy & Asthma Clinic, Singapore, Singapore – sequence: 20 givenname: Pascal M. surname: Demoly fullname: Demoly, Pascal M. organization: University Hospital Montpellier, Montpellier, France – sequence: 21 givenname: Lawrence M. surname: DuBuske fullname: DuBuske, Lawrence M. organization: Immunology Research Institute of New England, Gardner, MA, USA – sequence: 22 givenname: Marta surname: Ferrer Puga fullname: Ferrer Puga, Marta organization: The Unidad de Educación Médica, Department of Medical Education, School of Medicine, Clinica Universitad de Navarra, Navarra, Spain – sequence: 23 givenname: Roy surname: Gerth van Wijk fullname: Gerth van Wijk, Roy organization: Erasmus MC, Sector Allergologie, Rotterdam, the Netherlands – sequence: 24 givenname: Sandra Nora surname: González Díaz fullname: González Díaz, Sandra Nora organization: Universidad Autónoma de Nuevo León, Hospital Universitario, Monterrey, Nuevo León, Mexico – sequence: 25 givenname: Alexei surname: Gonzalez-Estrada fullname: Gonzalez-Estrada, Alexei organization: Department of Allergy, Mayo Clinic, Jacksonville, FL, USA – sequence: 26 givenname: Edgardo surname: Jares fullname: Jares, Edgardo organization: Femeca Femedica, Buenos Aires, Argentina – sequence: 27 givenname: Ayse Füsun surname: Kalpaklioğlu fullname: Kalpaklioğlu, Ayse Füsun organization: Kirikkale Universitesi, Tip Fakultesi, Kirikkale, Turkey – sequence: 28 givenname: Luciana surname: Kase Tanno fullname: Kase Tanno, Luciana organization: Hospital Sírio Libanês, University of São Paulo, São Paulo, Brazil – sequence: 29 givenname: Marek L. surname: Kowalski fullname: Kowalski, Marek L. organization: Faculty of Medicine, Department of Clinical Immunology & Allergy, Medical University of Łódź, Łódź, Poland – sequence: 30 givenname: Dennis K. surname: Ledford fullname: Ledford, Dennis K. organization: University of South Florida College of Medicine, Tampa, FL, USA – sequence: 31 givenname: Olga Patricia surname: Monge Ortega fullname: Monge Ortega, Olga Patricia organization: Allergology Unit, San Juan de Dios Hospital, University of Costa Rica, San José, Costa Rica – sequence: 32 givenname: Mário surname: Morais Almeida fullname: Morais Almeida, Mário organization: Hospital CUF-Descobertas, Lisbon, Portugal – sequence: 33 givenname: Oliver surname: Pfaar fullname: Pfaar, Oliver organization: Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany – sequence: 34 givenname: Lars K. surname: Poulsen fullname: Poulsen, Lars K. organization: Gentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, Denmark – sequence: 35 givenname: Ruby surname: Pawankar fullname: Pawankar, Ruby organization: Nippon Medical School, Dept. of Otolaryngology, Tokyo, Japan – sequence: 36 givenname: Harald E. surname: Renz fullname: Renz, Harald E. organization: University Hospital GI & MR GmbH, Institute of Laboratory Medicine & Pathology, Standort Marburg, Marburg, Germany – sequence: 37 givenname: Antonino G. surname: Romano fullname: Romano, Antonino G. organization: IRCCS Oasi Maria S.S., Troina, Italy – sequence: 38 givenname: Nelson A. surname: Rosário Filho fullname: Rosário Filho, Nelson A. organization: University of Parana, Curitiba, PR, Brazil – sequence: 39 givenname: Lanny surname: Rosenwasser fullname: Rosenwasser, Lanny organization: University of Missouri at Kansas City, School of Medicine, Kansas City, MO, USA – sequence: 40 givenname: Mario A. surname: Sánchez Borges fullname: Sánchez Borges, Mario A. organization: Centro Médico Docente La Trinidad, Caracas, Venezuela – sequence: 41 givenname: Enrico surname: Scala fullname: Scala, Enrico organization: Experimental Allergy Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy – sequence: 42 givenname: Gian-Enrico surname: Senna fullname: Senna, Gian-Enrico organization: Ospedale Civile Maggiore, Verona, Italy – sequence: 43 givenname: Juan Carlos surname: Sisul fullname: Sisul, Juan Carlos organization: Allergy & Asthma Institute, Asunción, Paraguay – sequence: 44 givenname: Mimi L.K. surname: Tang fullname: Tang, Mimi L.K. organization: Royal Children's Hospital, Department of Allergy & Immunology, Parkville, Victoria, Australia – sequence: 45 givenname: Bernard Yu-Hor surname: Thong fullname: Thong, Bernard Yu-Hor organization: Tan Tock Seng Hospital, Deptartment of Rheumatology, Allergy & Immunology, Singapore, Singapore – sequence: 46 givenname: Rudolf surname: Valenta fullname: Valenta, Rudolf organization: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria – sequence: 47 givenname: Robert A. surname: Wood fullname: Wood, Robert A. organization: Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA – sequence: 48 givenname: Torsten surname: Zuberbier fullname: Zuberbier, Torsten organization: Campus Charite Mitte, Klinik fur Dermatologie & Allergologie, Berlin, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32128023$$D View this record in MEDLINE/PubMed https://hal.science/hal-03228161$$DView record in HAL |
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| Keywords | Allergy Diagnostic strategies AU/mL Anti-IgE LAMP-3 SPT IDT NMBAs EIA AEC In vitro tests EAACI CaFE MRGPRX2 SCAR AIT AP IVD FEIA FcεRI AAAAI Skin tests DBPCFC NPA ELISA ABA PPA sIgE FDA CBA IgE HPO FACS CDER PPT NSAIDs MBAD w/v ENPP-3 BAU/mL EMEA CCD CL H1 H2 pNPP NIH ISAC mAb ACAAI IUIS BAT RAST kUA/L NMBAs, NeuroMuscular Blocking Agents EIA, Enzyme Immune Assay RAST, Radio Allergo Sorbent Test FEIA, Fluorescent Enzyme Immunoassays NSAIDs, Non-Steroidal Anti-Inflammatory Drugs NPA, Negative Percent Agreement H2, Histamine 2 receptor AEC, Allergen Exposure Chambers ELISA, Enzyme Linked Immuno Sorbent Analysis ENPP-3, EctoNucleotide Pyrophosphatase/Phosphodiesterase 3 DBPCFC, Double-Blind Placebo-Controlled Food Challenge mAb, Monoclonal Antibody FDA, Food and Drug Administration (U.S. Department of Health and Human Services) SCAR, severe cutaneous adverse drug reactions pNPP, p-Nitrophenylphosphate sIgE, specific IgE ABA, Allergen Bead Array ACAAI, American College of Allergy Asthma and Immunology FcεRI, High affinity IgE receptor CaFE, Calibrated Fluorescence Enhancement IDT, Intradermal Test ISAC, Immuno-Solid phase Allergen Chip MBAD, Molecule Based Allergy Diagnostics kUA/L, kilo Units of Allergen/Liter for allergen-specific IgE antibody assays BAU/mL, Biologic Allergenic Units milliLiter BAT, Basophil Activation Test LAMP-3, Lysosomal-Associated Membrane Protein CL, Chemiluminescence EAACI, European Academy of Allergy and Immunology IUIS, International Union of Immunological Societies CCD, Cross-reactive Carbohydrate Determinants NIH, National Institutes of Health (USA) HPO, Horseradish Peroxidase AAAAI, American Academy of Allergy Asthma and Immunology AU/mL, Allergenic Units milliLiter MRGPRX2, Mas-related G protein receptor 2 w/v, weight /volume FACS, Fluorescence-Activated Cell Sorting EMEA, European MEdicine Agencies IgE, immunoglobulin E PPT, Prick-Prick Test AIT, allergen immunotherapy H1, Histamine 1 receptor SPT, Skin prick test AP, Alkaline Phosphatase CDER, Center for Drug Evaluation and Research (USA) IVD, in vitro diagnostic tool CBA, Cytometric Bead Array Anti-IgE, Antibody against IgE PPA, Positive Percent Agreement In vitro tests |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. 2019 The Authors. Attribution - NonCommercial - NoDerivatives: http://creativecommons.org/licenses/by-nc-nd This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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| Title | IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper |
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