Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy

Background While large-scale cancer genomic projects are comprehensively characterizing the mutational spectrum of various cancers, so far little attention has been devoted to either define the antigenicity of these mutations or to characterize the immune responses they elicit. Here we present a str...

Full description

Saved in:

Bibliographic Details
Published in:	Genome Biology Vol. 16; no. 1; p. 64
Main Authors:	Angelova, Mihaela, Charoentong, Pornpimol, Hackl, Hubert, Fischer, Maria L, Snajder, Rene, Krogsdam, Anne M, Waldner, Maximilian J, Bindea, Gabriela, Mlecnik, Bernhard, Galon, Jerome, Trajanoski, Zlatko
Format:	Journal Article
Language:	English
Published:	London BioMed Central 31.03.2015 Springer Nature B.V
Subjects:	Animal Genetics and Genomics Animals Antigenicity Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Bioinformatics Biomedical and Life Sciences Cancer immunotherapy Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CCR8 protein Colorectal cancer Colorectal carcinoma colorectal neoplasms Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Evolutionary Biology Gene expression Genetic analysis genome Genomes Genomics Genotype & phenotype Human Genetics Human health and pathology Humans Immune response Immunodeficiency Immunogenicity Immunomodulation Immunophenotyping immunosuppression Immunotherapy Life Sciences Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Major histocompatibility complex Medical prognosis Mice Microbial Genetics and Genomics Patients Peptides Phenotypes Plant Genetics and Genomics regression analysis Studies T cell receptors Tumor Escape - genetics Tumor Escape - immunology Tumor-infiltrating lymphocytes Tumors Vaccination Vaccines Immune Cell Type Cancer Vaccination Molecular Phenotype Immunosuppressive Cell Human Leukocyte Antigen Class
ISSN:	1465-6906, 1474-7596, 1474-760X, 1465-6906, 1474-760X, 1465-6914
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!