Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broad...

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Bibliographic Details
Published in:	Leukemia Vol. 29; no. 12; pp. 2285 - 2295
Main Authors:	Huan, J, Hornick, N I, Goloviznina, N A, Kamimae- Lanning, A N, David, L L, Wilmarth, P A, Mori, T, Chevillet, J R, Narla, A, Roberts, C T, Loriaux, M M, Chang, B H, Kurre, P
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2015 Nature Publishing Group
Subjects:	13/100 13/106 13/21 13/31 13/51 14/35 38/77 38/79 38/90 631/250/1620/1342 631/378/548/2590 631/67/1990/283/1897 64/60 692/699/1541/1990/283/1897 82/51 82/79 Acute myeloid leukemia Animals Biosynthesis Bone marrow Bone Marrow - physiopathology c-Kit protein c-Myb protein Cancer Research Cell Movement Cells (biology) Cellular proteins Cellular signal transduction Critical Care Medicine CXCL12 protein CXCR4 protein Exosomes Exosomes - physiology Experiments Gene silencing Genetic aspects Genetic regulation Health aspects Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - physiology HL-60 Cells Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - physiopathology Medical research Medicine Medicine & Public Health Mice Mice, Inbred C57BL Myeloid leukemia Neovascularization Oncology original-article Paracrine signalling Pediatrics Progenitor cells Proteomics Ribonucleic acid RNA Science Stem cells Stromal cells Transcription factors Tumor cell lines Xenografts Xenotransplantation United States Oregon United States > US
ISSN:	0887-6924, 1476-5551
Online Access:	Get full text
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