Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes
We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broad...
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| Vydáno v: | Leukemia Ročník 29; číslo 12; s. 2285 - 2295 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
01.12.2015
Nature Publishing Group |
| Témata: | |
| ISSN: | 0887-6924, 1476-5551 |
| On-line přístup: | Získat plný text |
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| Abstract | We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an
in vitro
transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broader role in shaping the leukemic niche. In a series of
in vitro
studies and murine xenografts, we demonstrate that AML exosomes downregulate critical retention factors (
Scf
,
Cxcl12
) in stromal cells, leading to hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow. Exosome trafficking also regulates HSPC directly, and we demonstrate declining clonogenicity, loss of CXCR4 and c-Kit expression, and the consistent repression of several hematopoietic transcription factors, including
c-Myb
,
Cebp-β
and
Hoxa-9
. Additional experiments using a model of extramedullary AML or direct intrafemoral injection of purified exosomes reveal that the erosion of HSPC function can occur independent of direct cell–cell contact with leukemia cells. Finally, using a novel multiplex proteomics technique, we identified candidate pathways involved in the direct exosome-mediated modulation of HSPC function. In aggregate, this work suggests that AML exosomes participate in the suppression of residual hematopoietic function that precedes widespread leukemic invasion of the bone marrow directly and indirectly via stromal components. |
|---|---|
| AbstractList | We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an
in vitro
transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broader role in shaping the leukemic niche. In a series of
in vitro
studies and murine xenografts, we demonstrate that AML exosomes downregulate critical retention factors (
Scf
,
Cxcl12
) in stromal cells, leading to hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow. Exosome trafficking also regulates HSPC directly, and we demonstrate declining clonogenicity, loss of CXCR4 and c-Kit expression, and the consistent repression of several hematopoietic transcription factors, including
c-Myb
,
Cebp-β
and
Hoxa-9
. Additional experiments using a model of extramedullary AML or direct intrafemoral injection of purified exosomes reveal that the erosion of HSPC function can occur independent of direct cell–cell contact with leukemia cells. Finally, using a novel multiplex proteomics technique, we identified candidate pathways involved in the direct exosome-mediated modulation of HSPC function. In aggregate, this work suggests that AML exosomes participate in the suppression of residual hematopoietic function that precedes widespread leukemic invasion of the bone marrow directly and indirectly via stromal components. We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broader role in shaping the leukemic niche. In a series of in vitro studies and murine xenografts, we demonstrate that AML exosomes downregulate critical retention factors (Scf, Cxcl12) in stromal cells, leading to hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow. Exosome trafficking also regulates HSPC directly, and we demonstrate declining clonogenicity, loss of CXCR4 and c-Kit expression, and the consistent repression of several hematopoietic transcription factors, including c-Myb, Cebp- beta and Hoxa-9. Additional experiments using a model of extramedullary AML or direct intrafemoral injection of purified exosomes reveal that the erosion of HSPC function can occur independent of direct cell-cell contact with leukemia cells. Finally, using a novel multiplex proteomics technique, we identified candidate pathways involved in the direct exosome-mediated modulation of HSPC function. In aggregate, this work suggests that AML exosomes participate in the suppression of residual hematopoietic function that precedes widespread leukemic invasion of the bone marrow directly and indirectly via stromal components. We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broader role in shaping the leukemic niche. In a series of in vitro studies and murine xenografts, we demonstrate that AML exosomes downregulate critical retention factors (Scf, Cxcl12) in stromal cells, leading to hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow. Exosome trafficking also regulates HSPC directly, and we demonstrate declining clonogenicity, loss of CXCR4 and c-Kit expression, and the consistent repression of several hematopoietic transcription factors, including c-Myb, Cebp-β and Hoxa-9. Additional experiments using a model of extramedullary AML or direct intrafemoral injection of purified exosomes reveal that the erosion of HSPC function can occur independent of direct cell-cell contact with leukemia cells. Finally, using a novel multiplex proteomics technique, we identified candidate pathways involved in the direct exosome-mediated modulation of HSPC function. In aggregate, this work suggests that AML exosomes participate in the suppression of residual hematopoietic function that precedes widespread leukemic invasion of the bone marrow directly and indirectly via stromal components. We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broader role in shaping the leukemic niche. In a series of in vitro studies and murine xenografts, we demonstrate that AML exosomes downregulate critical retention factors (Scf, Cxcl12) in stromal cells, leading to hematopoietic stem and progenitor cell (HSPC) mobilization from the bone marrow. Exosome trafficking also regulates HSPC directly, and we demonstrate declining clonogenicity, loss of CXCR4 and c-Kit expression, and the consistent repression of several hematopoietic transcription factors, including c-Myb, Cebp-β and Hoxa-9. Additional experiments using a model of extramedullary AML or direct intrafemoral injection of purified exosomes reveal that the erosion of HSPC function can occur independent of direct cell-cell contact with leukemia cells. Finally, using a novel multiplex proteomics technique, we identified candidate pathways involved in the direct exosome-mediated modulation of HSPC function. In aggregate, this work suggests that AML exosomes participate in the suppression of residual hematopoietic function that precedes widespread leukemic invasion of the bone marrow directly and indirectly via stromal components. Leukemia (2015) 29, 2285-2295;doi:10.1038/leu.2015.163 |
| Audience | Academic |
| Author | Chevillet, J R Chang, B H Loriaux, M M Narla, A Hornick, N I Mori, T Goloviznina, N A Kamimae- Lanning, A N Huan, J Roberts, C T Kurre, P David, L L Wilmarth, P A |
| AuthorAffiliation | 2 Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA 5 Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA 3 Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, USA 6 Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA 7 Division of Hematology/Oncology, Stanford University, Palo Alto, CA, USA 1 Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA 8 Department of Medicine, Oregon Health & Science University, Portland, OR, USA 4 Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR, USA 9 Oregon National Primate Research Center, Beaverton, OR, USA |
| AuthorAffiliation_xml | – name: 3 Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, USA – name: 7 Division of Hematology/Oncology, Stanford University, Palo Alto, CA, USA – name: 8 Department of Medicine, Oregon Health & Science University, Portland, OR, USA – name: 4 Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR, USA – name: 5 Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA – name: 1 Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA – name: 6 Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA – name: 9 Oregon National Primate Research Center, Beaverton, OR, USA – name: 2 Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR, USA |
| Author_xml | – sequence: 1 givenname: J surname: Huan fullname: Huan, J organization: Department of Pediatrics, Oregon Health & Science University, Papé Family Pediatric Research Institute, Oregon Health & Science University, Oregon Stem Cell Center, Oregon Health & Science University – sequence: 2 givenname: N I surname: Hornick fullname: Hornick, N I organization: Department of Pediatrics, Oregon Health & Science University, Papé Family Pediatric Research Institute, Oregon Health & Science University, Oregon Stem Cell Center, Oregon Health & Science University – sequence: 3 givenname: N A surname: Goloviznina fullname: Goloviznina, N A organization: Department of Pediatrics, Oregon Health & Science University, Papé Family Pediatric Research Institute, Oregon Health & Science University, Oregon Stem Cell Center, Oregon Health & Science University – sequence: 4 givenname: A N surname: Kamimae- Lanning fullname: Kamimae- Lanning, A N organization: Department of Pediatrics, Oregon Health & Science University, Papé Family Pediatric Research Institute, Oregon Health & Science University, Oregon Stem Cell Center, Oregon Health & Science University – sequence: 5 givenname: L L surname: David fullname: David, L L organization: Department of Biochemistry and Molecular Biology, Oregon Health & Science University – sequence: 6 givenname: P A surname: Wilmarth fullname: Wilmarth, P A organization: Department of Biochemistry and Molecular Biology, Oregon Health & Science University – sequence: 7 givenname: T surname: Mori fullname: Mori, T organization: Knight Cancer Institute, Oregon Health & Science University – sequence: 8 givenname: J R surname: Chevillet fullname: Chevillet, J R organization: Division of Human Biology, Fred Hutchinson Cancer Research Center – sequence: 9 givenname: A surname: Narla fullname: Narla, A organization: Division of Hematology/Oncology, Stanford University – sequence: 10 givenname: C T surname: Roberts fullname: Roberts, C T organization: Department of Pediatrics, Oregon Health & Science University, Department of Medicine, Oregon Health & Science University, Oregon National Primate Research Center – sequence: 11 givenname: M M surname: Loriaux fullname: Loriaux, M M organization: Knight Cancer Institute, Oregon Health & Science University, Department of Medicine, Oregon Health & Science University – sequence: 12 givenname: B H surname: Chang fullname: Chang, B H organization: Department of Pediatrics, Oregon Health & Science University, Knight Cancer Institute, Oregon Health & Science University – sequence: 13 givenname: P surname: Kurre fullname: Kurre, P email: kurrepe@ohsu.edu organization: Department of Pediatrics, Oregon Health & Science University, Papé Family Pediatric Research Institute, Oregon Health & Science University, Oregon Stem Cell Center, Oregon Health & Science University, Knight Cancer Institute, Oregon Health & Science University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26108689$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1073/pnas.1301891110 10.1242/jcs.100123 10.1038/onc.2011.579 10.1016/j.ccr.2014.01.022 10.1182/blood.V97.5.1172 10.1021/ac301572t 10.1128/MCB.01161-08 10.1016/j.molcel.2009.09.006 10.1158/0008-5472.CAN-12-2184 10.1038/leu.2009.175 10.1038/nm886 10.1073/pnas.1220998110 10.1073/pnas.93.9.4040 10.1021/pr050473a 10.1016/j.ccr.2011.10.012 10.1007/978-1-59745-409-4_12 10.1038/sj.leu.2404132 10.1182/blood-2008-10-185686 10.1016/j.stem.2014.06.001 10.1038/nm.2753 10.1093/nar/gkn923 10.1038/nrc3536 10.1089/107999001753238105 10.1126/science.1164390 10.1038/nri2765 10.1158/0008-5472.CAN-13-0265 10.1016/j.immuni.2006.10.016 10.1016/j.ccr.2009.08.018 10.1016/j.stem.2011.03.006 10.1038/nm1483 10.1172/JCI66553 10.1038/nmeth1113 10.1182/blood.V99.1.394 10.1016/j.stem.2013.06.009 10.1093/bioinformatics/btp616 10.1016/j.cell.2007.07.021 10.1038/nature07965 10.1182/blood-2013-06-511527 10.1038/nature13035 10.1074/jbc.M006250200 10.1016/j.ccr.2012.02.018 10.1038/nprot.2008.211 10.1093/nar/gkn760 10.1038/nature11926 10.1182/blood-2011-11-389957 10.1371/journal.pone.0053161 |
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| PublicationTitle | Leukemia |
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| PublicationYear | 2015 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
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| References | Mizuno, Chijiwa, Okamura, Akashi, Fukumaki, Niho (CR35) 2001; 97 Ratajczak, Miekus, Kucia, Zhang, Reca, Dvorak (CR6) 2006; 20 Skinner, Grompe, Kurre (CR16) 2012; 125 Wilmarth, Tanner, Dasari, Nagalla, Riviere, Bafna (CR17) 2006; 5 Jacamo, Chen, Wang, Ma, Zhang, Spaeth (CR34) 2014; 123 McAlister, Huttlin, Haas, Ting, Jedrychowski, Rogers (CR18) 2012; 84 Schepers, Pietras, Reynaud, Flach, Binnewies, Garg (CR22) 2013; 13 Harrison, Rameshwar, Chang, Bandari (CR10) 2002; 99 Gross, Poeck, Bscheider, Dostert, Hannesschlager, Endres (CR42) 2009; 459 Reynaud, Pietras, Barry-Holson, Mir, Binnewies, Jeanne (CR2) 2011; 20 Huan, Hornick, Shurtleff, Skinner, Goloviznina, Roberts (CR7) 2013; 73 Jin, Hope, Zhai, Smadja-Joffe, Dick (CR33) 2006; 12 Puissant, Fenouille, Alexe, Pikman, Bassil, Mehta (CR40) 2014; 25 Mazurier, Doedens, Gan, Dick (CR15) 2003; 9 Hatfield, Bedringsaas, Ryningen, Gjertsen, Bruserud (CR11) 2010; 21 Hartwig, Keller, Huber, Peschel (CR44) 2001; 21 Signer, Magee, Salic, Morrison (CR45) 2014; 509 Chong, Tsai, Sharma, Opavsky, Price, Wu (CR25) 2009; 29 Huang da, Sherman, Lempicki (CR31) 2009; 37 Pan (CR14) 2009; 506 Jensen, Kuhn, Stark, Chaffron, Creevey, Muller (CR32) 2009; 37 Colmone, Amorim, Pontier, Wang, Jablonski, Sipkins (CR5) 2008; 322 Chen, Jacamo, Konopleva, Garzon, Croce, Andreeff (CR8) 2013; 123 Sattler, Verma, Pride, Salgia, Rohrschneider, Griffin (CR26) 2001; 276 Xiao, Calado, Galler, Thai, Patterson, Wang (CR29) 2007; 131 Ghosh, Shanafelt, Cimmino, Taccioli, Volinia, Liu (CR23) 2009; 113 Sugiyama, Kohara, Noda, Nagasawa (CR36) 2006; 25 Mocsai, Ruland, Tybulewicz (CR39) 2010; 10 Zhang, Ho, Huang, Maeda, Lin, Lee (CR3) 2012; 21 Huang da, Sherman, Lempicki (CR30) 2009; 4 Kucharzewska, Christianson, Welch, Svensson, Fredlund, Ringner (CR21) 2013; 110 Peinado, Aleckovic, Lavotshkin, Matei, Costa-Silva, Moreno-Bueno (CR46) 2012; 18 Chen, Jacamo, Shi, Wang, Battula, Konoplev (CR13) 2012; 119 Lee, Futami, Carroll, Feng, Wang, Fernandez (CR28) 2012; 31 Barcellos-Hoff, Lyden, Wang (CR47) 2013; 13 Ayala, Dewar, Kieran, Kalluri (CR1) 2009; 23 Kall, Canterbury, Weston, Noble, MacCoss (CR19) 2007; 4 Hahn, Berchuck, Ross, Kakoza, Clauser, Schinzel (CR41) 2009; 16 Greenbaum, Hsu, Day, Schuettpelz, Christopher, Borgerding (CR38) 2013; 495 Huang, Ding, Bennewith, Tong, Welford, Ang (CR27) 2009; 35 Lam, Adams (CR12) 2011; 8 Miraki-Moud, Anjos-Afonso, Hodby, Griessinger, Rosignoli, Lillington (CR4) 2013; 110 Cosgun, Rahmig, Mende, Reinke, Hauber, Schafer (CR37) 2014; 15 Yonemura, Ku, Hirayama, Souza, Ogawa (CR43) 1996; 93 Robinson, McCarthy, Smyth (CR20) 2010; 26 Roberts, Kurre (CR9) 2013; 73 Ohno, Yasunaga, Janmohamed, Ohtsubo, Saeki, Kurogi (CR24) 2013; 8 P Kucharzewska (BFleu2015163_CR21) 2013; 110 C Xiao (BFleu2015163_CR29) 2007; 131 CK Hahn (BFleu2015163_CR41) 2009; 16 A Colmone (BFleu2015163_CR5) 2008; 322 D Pan (BFleu2015163_CR14) 2009; 506 F Mazurier (BFleu2015163_CR15) 2003; 9 JS Harrison (BFleu2015163_CR10) 2002; 99 F Ayala (BFleu2015163_CR1) 2009; 23 J Huan (BFleu2015163_CR7) 2013; 73 Y Chen (BFleu2015163_CR13) 2012; 119 L Kall (BFleu2015163_CR19) 2007; 4 LJ Jensen (BFleu2015163_CR32) 2009; 37 DW Lee (BFleu2015163_CR28) 2012; 31 S Mizuno (BFleu2015163_CR35) 2001; 97 F Miraki-Moud (BFleu2015163_CR4) 2013; 110 A Puissant (BFleu2015163_CR40) 2014; 25 GC McAlister (BFleu2015163_CR18) 2012; 84 M Sattler (BFleu2015163_CR26) 2001; 276 W Huang da (BFleu2015163_CR31) 2009; 37 BS Lam (BFleu2015163_CR12) 2011; 8 Y Chen (BFleu2015163_CR8) 2013; 123 Y Ohno (BFleu2015163_CR24) 2013; 8 MH Barcellos-Hoff (BFleu2015163_CR47) 2013; 13 J Ratajczak (BFleu2015163_CR6) 2006; 20 R Jacamo (BFleu2015163_CR34) 2014; 123 A Greenbaum (BFleu2015163_CR38) 2013; 495 H Peinado (BFleu2015163_CR46) 2012; 18 AK Ghosh (BFleu2015163_CR23) 2009; 113 L Jin (BFleu2015163_CR33) 2006; 12 MD Robinson (BFleu2015163_CR20) 2010; 26 RA Signer (BFleu2015163_CR45) 2014; 509 K Schepers (BFleu2015163_CR22) 2013; 13 KN Cosgun (BFleu2015163_CR37) 2014; 15 W Huang da (BFleu2015163_CR30) 2009; 4 CT Roberts Jr (BFleu2015163_CR9) 2013; 73 JL Chong (BFleu2015163_CR25) 2009; 29 Y Yonemura (BFleu2015163_CR43) 1996; 93 D Reynaud (BFleu2015163_CR2) 2011; 20 T Sugiyama (BFleu2015163_CR36) 2006; 25 PA Wilmarth (BFleu2015163_CR17) 2006; 5 X Huang (BFleu2015163_CR27) 2009; 35 B Zhang (BFleu2015163_CR3) 2012; 21 KJ Hatfield (BFleu2015163_CR11) 2010; 21 O Gross (BFleu2015163_CR42) 2009; 459 UF Hartwig (BFleu2015163_CR44) 2001; 21 AM Skinner (BFleu2015163_CR16) 2012; 125 A Mocsai (BFleu2015163_CR39) 2010; 10 20729179 - Eur Cytokine Netw. 2010 Sep;21(3):154-64 19336759 - Blood. 2009 May 28;113(22):5568-74 23901108 - Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13576-81 19782034 - Mol Cell. 2009 Sep 24;35(6):856-67 24599548 - Blood. 2014 Apr 24;123(17):2691-702 19727127 - Leukemia. 2009 Dec;23(12):2233-41 22094259 - Cancer Cell. 2011 Nov 15;20(5):661-73 17952086 - Nat Methods. 2007 Nov;4(11):923-5 19033363 - Nucleic Acids Res. 2009 Jan;37(1):1-13 16453000 - Leukemia. 2006 May;20(5):847-56 12796774 - Nat Med. 2003 Jul;9(7):959-63 21474097 - Cell Stem Cell. 2011 Apr 8;8(4):354-6 23850243 - Cell Stem Cell. 2013 Sep 5;13(3):285-99 23149911 - Cancer Res. 2013 Jan 15;73(2):918-29 18940858 - Nucleic Acids Res. 2009 Jan;37(Database issue):D412-6 22393240 - J Cell Sci. 2012 Jun 15;125(Pt 12):2837-43 22880955 - Anal Chem. 2012 Sep 4;84(17):7469-78 23434756 - Nature. 2013 Mar 14;495(7440):227-30 22516264 - Cancer Cell. 2012 Apr 17;21(4):577-92 11222358 - Blood. 2001 Mar 1;97(5):1172-9 23589885 - Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7 23326393 - PLoS One. 2013;8(1):e53161 17022627 - J Proteome Res. 2006 Oct;5(10):2554-66 23695552 - Cancer Res. 2013 Jun 1;73(11):3200-5 19095944 - Science. 2008 Dec 19;322(5909):1861-5 24670665 - Nature. 2014 May 1;509(7498):49-54 22249254 - Oncogene. 2012 Sep 13;31(37):4085-94 19910308 - Bioinformatics. 2010 Jan 1;26(1):139-40 11710998 - J Interferon Cytokine Res. 2001 Oct;21(10):851-60 23676502 - J Clin Invest. 2013 Jun;123(6):2395-407 11031258 - J Biol Chem. 2001 Jan 26;276(4):2451-8 11783438 - Blood. 2002 Jan 1;99(1):394 24525236 - Cancer Cell. 2014 Feb 10;25(2):226-42 19800574 - Cancer Cell. 2009 Oct 6;16(4):281-94 23760023 - Nat Rev Cancer. 2013 Jul;13(7):511-8 19339971 - Nature. 2009 May 21;459(7245):433-6 20467426 - Nat Rev Immunol. 2010 Jun;10(6):387-402 25017720 - Cell Stem Cell. 2014 Aug 7;15(2):227-38 16998484 - Nat Med. 2006 Oct;12(10):1167-74 22490334 - Blood. 2012 May 24;119(21):4971-80 22635005 - Nat Med. 2012 Jun;18(6):883-91 17923094 - Cell. 2007 Oct 5;131(1):146-59 17174120 - Immunity. 2006 Dec;25(6):977-88 19110626 - Methods Mol Biol. 2009;506:159-69 8633013 - Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4040-4 19015245 - Mol Cell Biol. 2009 Jan;29(2):414-24 19131956 - Nat Protoc. 2009;4(1):44-57 |
| References_xml | – volume: 110 start-page: 13576 year: 2013 end-page: 13581 ident: CR4 article-title: Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1301891110 – volume: 125 start-page: 2837 year: 2012 end-page: 2843 ident: CR16 article-title: Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system publication-title: J Cell Sci doi: 10.1242/jcs.100123 – volume: 31 start-page: 4085 year: 2012 end-page: 4094 ident: CR28 article-title: Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155 publication-title: Oncogene doi: 10.1038/onc.2011.579 – volume: 25 start-page: 226 year: 2014 end-page: 242 ident: CR40 article-title: SYK is a critical regulator of FLT3 in acute myeloid leukemia publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.01.022 – volume: 97 start-page: 1172 year: 2001 end-page: 1179 ident: CR35 article-title: Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia publication-title: Blood doi: 10.1182/blood.V97.5.1172 – volume: 21 start-page: 154 year: 2010 end-page: 164 ident: CR11 article-title: Hypoxia increases HIF- 1alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells publication-title: Eur Cyt Netw – volume: 84 start-page: 7469 year: 2012 end-page: 7478 ident: CR18 article-title: Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses publication-title: Anal Chem doi: 10.1021/ac301572t – volume: 29 start-page: 414 year: 2009 end-page: 424 ident: CR25 article-title: E2f3a and E2f3b contribute to the control of cell proliferation and mouse development publication-title: Mol Cell Biol doi: 10.1128/MCB.01161-08 – volume: 35 start-page: 856 year: 2009 end-page: 867 ident: CR27 article-title: Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation publication-title: Mol Cell doi: 10.1016/j.molcel.2009.09.006 – volume: 73 start-page: 918 year: 2013 end-page: 929 ident: CR7 article-title: RNA trafficking by acute myelogenous leukemia exosomes publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-2184 – volume: 23 start-page: 2233 year: 2009 end-page: 2241 ident: CR1 article-title: Contribution of bone microenvironment to leukemogenesis and leukemia progression publication-title: Leukemia doi: 10.1038/leu.2009.175 – volume: 9 start-page: 959 year: 2003 end-page: 963 ident: CR15 article-title: Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells publication-title: Nat Med doi: 10.1038/nm886 – volume: 110 start-page: 7312 year: 2013 end-page: 7317 ident: CR21 article-title: Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1220998110 – volume: 93 start-page: 4040 year: 1996 end-page: 4044 ident: CR43 article-title: Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.9.4040 – volume: 5 start-page: 2554 year: 2006 end-page: 2566 ident: CR17 article-title: Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility? publication-title: J Proteome Res doi: 10.1021/pr050473a – volume: 20 start-page: 661 year: 2011 end-page: 673 ident: CR2 article-title: IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.10.012 – volume: 506 start-page: 159 year: 2009 end-page: 169 ident: CR14 article-title: gene transfer into murine bone marrow stem cells publication-title: Methods Mol Biol doi: 10.1007/978-1-59745-409-4_12 – volume: 20 start-page: 847 year: 2006 end-page: 856 ident: CR6 article-title: Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery publication-title: Leukemia doi: 10.1038/sj.leu.2404132 – volume: 113 start-page: 5568 year: 2009 end-page: 5574 ident: CR23 article-title: Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells publication-title: Blood doi: 10.1182/blood-2008-10-185686 – volume: 15 start-page: 227 year: 2014 end-page: 238 ident: CR37 article-title: Kit regulates HSC engraftment across the human-mouse species barrier publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.06.001 – volume: 18 start-page: 883 year: 2012 end-page: 891 ident: CR46 article-title: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET publication-title: Nat Med doi: 10.1038/nm.2753 – volume: 37 start-page: 1 year: 2009 end-page: 13 ident: CR31 article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn923 – volume: 13 start-page: 511 year: 2013 end-page: 518 ident: CR47 article-title: The evolution of the cancer niche during multistage carcinogenesis publication-title: Nat Rev Cancer doi: 10.1038/nrc3536 – volume: 21 start-page: 851 year: 2001 end-page: 860 ident: CR44 article-title: Regulation of hematopoietic growth factor production by genetically modified human bone marrow stromal cells expressing interleukin-1beta antisense RNA publication-title: J Interferon Cytokine Res doi: 10.1089/107999001753238105 – volume: 322 start-page: 1861 year: 2008 end-page: 1865 ident: CR5 article-title: Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells publication-title: Science doi: 10.1126/science.1164390 – volume: 10 start-page: 387 year: 2010 end-page: 402 ident: CR39 article-title: The SYK tyrosine kinase: a crucial player in diverse biological functions publication-title: Nat Rev Immunol doi: 10.1038/nri2765 – volume: 73 start-page: 3200 year: 2013 end-page: 3205 ident: CR9 article-title: Vesicle trafficking and RNA transfer add complexity and connectivity to cell-cell communication publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-0265 – volume: 25 start-page: 977 year: 2006 end-page: 988 ident: CR36 article-title: Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches publication-title: Immunity doi: 10.1016/j.immuni.2006.10.016 – volume: 16 start-page: 281 year: 2009 end-page: 294 ident: CR41 article-title: Proteomic and genetic approaches identify Syk as an AML target publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.08.018 – volume: 8 start-page: 354 year: 2011 end-page: 356 ident: CR12 article-title: Blocking HIF1alpha activity eliminates hematological cancer stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.03.006 – volume: 12 start-page: 1167 year: 2006 end-page: 1174 ident: CR33 article-title: Targeting of CD44 eradicates human acute myeloid leukemic stem cells publication-title: Nat Med doi: 10.1038/nm1483 – volume: 123 start-page: 2395 year: 2013 end-page: 2407 ident: CR8 article-title: CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia publication-title: J Clin Invest doi: 10.1172/JCI66553 – volume: 4 start-page: 923 year: 2007 end-page: 925 ident: CR19 article-title: Semi-supervised learning for peptide identification from shotgun proteomics datasets publication-title: Nat Methods doi: 10.1038/nmeth1113 – volume: 99 start-page: 394 year: 2002 ident: CR10 article-title: Oxygen saturation in the bone marrow of healthy volunteers publication-title: Blood doi: 10.1182/blood.V99.1.394 – volume: 13 start-page: 285 year: 2013 end-page: 299 ident: CR22 article-title: Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche publication-title: Cell Stem Cell doi: 10.1016/j.stem.2013.06.009 – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: CR20 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 131 start-page: 146 year: 2007 end-page: 159 ident: CR29 article-title: MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb publication-title: Cell doi: 10.1016/j.cell.2007.07.021 – volume: 459 start-page: 433 year: 2009 end-page: 436 ident: CR42 article-title: Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence publication-title: Nature doi: 10.1038/nature07965 – volume: 123 start-page: 2691 year: 2014 end-page: 2702 ident: CR34 article-title: Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-kappaB mediates chemoresistance publication-title: Blood doi: 10.1182/blood-2013-06-511527 – volume: 509 start-page: 49 year: 2014 end-page: 54 ident: CR45 article-title: Haematopoietic stem cells require a highly regulated protein synthesis rate publication-title: Nature doi: 10.1038/nature13035 – volume: 276 start-page: 2451 year: 2001 end-page: 2458 ident: CR26 article-title: SHIP1 an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL publication-title: J Biol Chem doi: 10.1074/jbc.M006250200 – volume: 21 start-page: 577 year: 2012 end-page: 592 ident: CR3 article-title: Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.02.018 – volume: 4 start-page: 44 year: 2009 end-page: 57 ident: CR30 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nat Protoc doi: 10.1038/nprot.2008.211 – volume: 37 start-page: D412 year: 2009 end-page: D416 ident: CR32 article-title: STRING 8–a global view on proteins and their functional interactions in 630 organisms publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn760 – volume: 495 start-page: 227 year: 2013 end-page: 230 ident: CR38 article-title: CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance publication-title: Nature doi: 10.1038/nature11926 – volume: 119 start-page: 4971 year: 2012 end-page: 4980 ident: CR13 article-title: Human extramedullary bone marrow in mice: a novel model of genetically controlled hematopoietic microenvironment publication-title: Blood doi: 10.1182/blood-2011-11-389957 – volume: 8 start-page: e53161 year: 2013 ident: CR24 article-title: Hoxa9 transduction induces hematopoietic stem and progenitor cell activity through direct down-regulation of geminin protein publication-title: PloS One doi: 10.1371/journal.pone.0053161 – volume: 495 start-page: 227 year: 2013 ident: BFleu2015163_CR38 publication-title: Nature doi: 10.1038/nature11926 – volume: 21 start-page: 577 year: 2012 ident: BFleu2015163_CR3 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.02.018 – volume: 84 start-page: 7469 year: 2012 ident: BFleu2015163_CR18 publication-title: Anal Chem doi: 10.1021/ac301572t – volume: 29 start-page: 414 year: 2009 ident: BFleu2015163_CR25 publication-title: Mol Cell Biol doi: 10.1128/MCB.01161-08 – volume: 31 start-page: 4085 year: 2012 ident: BFleu2015163_CR28 publication-title: Oncogene doi: 10.1038/onc.2011.579 – volume: 37 start-page: 1 year: 2009 ident: BFleu2015163_CR31 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn923 – volume: 21 start-page: 851 year: 2001 ident: BFleu2015163_CR44 publication-title: J Interferon Cytokine Res doi: 10.1089/107999001753238105 – volume: 110 start-page: 13576 year: 2013 ident: BFleu2015163_CR4 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1301891110 – volume: 10 start-page: 387 year: 2010 ident: BFleu2015163_CR39 publication-title: Nat Rev Immunol doi: 10.1038/nri2765 – volume: 322 start-page: 1861 year: 2008 ident: BFleu2015163_CR5 publication-title: Science doi: 10.1126/science.1164390 – volume: 4 start-page: 44 year: 2009 ident: BFleu2015163_CR30 publication-title: Nat Protoc doi: 10.1038/nprot.2008.211 – volume: 12 start-page: 1167 year: 2006 ident: BFleu2015163_CR33 publication-title: Nat Med doi: 10.1038/nm1483 – volume: 20 start-page: 661 year: 2011 ident: BFleu2015163_CR2 publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.10.012 – volume: 506 start-page: 159 year: 2009 ident: BFleu2015163_CR14 publication-title: Methods Mol Biol doi: 10.1007/978-1-59745-409-4_12 – volume: 125 start-page: 2837 year: 2012 ident: BFleu2015163_CR16 publication-title: J Cell Sci doi: 10.1242/jcs.100123 – volume: 73 start-page: 918 year: 2013 ident: BFleu2015163_CR7 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-2184 – volume: 21 start-page: 154 year: 2010 ident: BFleu2015163_CR11 publication-title: Eur Cyt Netw – volume: 25 start-page: 977 year: 2006 ident: BFleu2015163_CR36 publication-title: Immunity doi: 10.1016/j.immuni.2006.10.016 – volume: 18 start-page: 883 year: 2012 ident: BFleu2015163_CR46 publication-title: Nat Med doi: 10.1038/nm.2753 – volume: 119 start-page: 4971 year: 2012 ident: BFleu2015163_CR13 publication-title: Blood doi: 10.1182/blood-2011-11-389957 – volume: 13 start-page: 285 year: 2013 ident: BFleu2015163_CR22 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2013.06.009 – volume: 113 start-page: 5568 year: 2009 ident: BFleu2015163_CR23 publication-title: Blood doi: 10.1182/blood-2008-10-185686 – volume: 35 start-page: 856 year: 2009 ident: BFleu2015163_CR27 publication-title: Mol Cell doi: 10.1016/j.molcel.2009.09.006 – volume: 123 start-page: 2691 year: 2014 ident: BFleu2015163_CR34 publication-title: Blood doi: 10.1182/blood-2013-06-511527 – volume: 99 start-page: 394 year: 2002 ident: BFleu2015163_CR10 publication-title: Blood doi: 10.1182/blood.V99.1.394 – volume: 16 start-page: 281 year: 2009 ident: BFleu2015163_CR41 publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.08.018 – volume: 23 start-page: 2233 year: 2009 ident: BFleu2015163_CR1 publication-title: Leukemia doi: 10.1038/leu.2009.175 – volume: 8 start-page: 354 year: 2011 ident: BFleu2015163_CR12 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2011.03.006 – volume: 5 start-page: 2554 year: 2006 ident: BFleu2015163_CR17 publication-title: J Proteome Res doi: 10.1021/pr050473a – volume: 37 start-page: D412 year: 2009 ident: BFleu2015163_CR32 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn760 – volume: 26 start-page: 139 year: 2010 ident: BFleu2015163_CR20 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 131 start-page: 146 year: 2007 ident: BFleu2015163_CR29 publication-title: Cell doi: 10.1016/j.cell.2007.07.021 – volume: 123 start-page: 2395 year: 2013 ident: BFleu2015163_CR8 publication-title: J Clin Invest doi: 10.1172/JCI66553 – volume: 4 start-page: 923 year: 2007 ident: BFleu2015163_CR19 publication-title: Nat Methods doi: 10.1038/nmeth1113 – volume: 459 start-page: 433 year: 2009 ident: BFleu2015163_CR42 publication-title: Nature doi: 10.1038/nature07965 – volume: 93 start-page: 4040 year: 1996 ident: BFleu2015163_CR43 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.9.4040 – volume: 509 start-page: 49 year: 2014 ident: BFleu2015163_CR45 publication-title: Nature doi: 10.1038/nature13035 – volume: 8 start-page: e53161 year: 2013 ident: BFleu2015163_CR24 publication-title: PloS One doi: 10.1371/journal.pone.0053161 – volume: 73 start-page: 3200 year: 2013 ident: BFleu2015163_CR9 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-13-0265 – volume: 15 start-page: 227 year: 2014 ident: BFleu2015163_CR37 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.06.001 – volume: 25 start-page: 226 year: 2014 ident: BFleu2015163_CR40 publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.01.022 – volume: 276 start-page: 2451 year: 2001 ident: BFleu2015163_CR26 publication-title: J Biol Chem doi: 10.1074/jbc.M006250200 – volume: 9 start-page: 959 year: 2003 ident: BFleu2015163_CR15 publication-title: Nat Med doi: 10.1038/nm886 – volume: 13 start-page: 511 year: 2013 ident: BFleu2015163_CR47 publication-title: Nat Rev Cancer doi: 10.1038/nrc3536 – volume: 20 start-page: 847 year: 2006 ident: BFleu2015163_CR6 publication-title: Leukemia doi: 10.1038/sj.leu.2404132 – volume: 110 start-page: 7312 year: 2013 ident: BFleu2015163_CR21 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1220998110 – volume: 97 start-page: 1172 year: 2001 ident: BFleu2015163_CR35 publication-title: Blood doi: 10.1182/blood.V97.5.1172 – reference: 17022627 - J Proteome Res. 2006 Oct;5(10):2554-66 – reference: 22516264 - Cancer Cell. 2012 Apr 17;21(4):577-92 – reference: 23589885 - Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7 – reference: 19800574 - Cancer Cell. 2009 Oct 6;16(4):281-94 – reference: 22249254 - Oncogene. 2012 Sep 13;31(37):4085-94 – reference: 19336759 - Blood. 2009 May 28;113(22):5568-74 – reference: 16453000 - Leukemia. 2006 May;20(5):847-56 – reference: 23434756 - Nature. 2013 Mar 14;495(7440):227-30 – reference: 22094259 - Cancer Cell. 2011 Nov 15;20(5):661-73 – reference: 23760023 - Nat Rev Cancer. 2013 Jul;13(7):511-8 – reference: 19015245 - Mol Cell Biol. 2009 Jan;29(2):414-24 – reference: 11783438 - Blood. 2002 Jan 1;99(1):394 – reference: 19131956 - Nat Protoc. 2009;4(1):44-57 – reference: 22635005 - Nat Med. 2012 Jun;18(6):883-91 – reference: 12796774 - Nat Med. 2003 Jul;9(7):959-63 – reference: 22393240 - J Cell Sci. 2012 Jun 15;125(Pt 12):2837-43 – reference: 20729179 - Eur Cytokine Netw. 2010 Sep;21(3):154-64 – reference: 23695552 - Cancer Res. 2013 Jun 1;73(11):3200-5 – reference: 23149911 - Cancer Res. 2013 Jan 15;73(2):918-29 – reference: 21474097 - Cell Stem Cell. 2011 Apr 8;8(4):354-6 – reference: 23326393 - PLoS One. 2013;8(1):e53161 – reference: 16998484 - Nat Med. 2006 Oct;12(10):1167-74 – reference: 8633013 - Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4040-4 – reference: 22490334 - Blood. 2012 May 24;119(21):4971-80 – reference: 19910308 - Bioinformatics. 2010 Jan 1;26(1):139-40 – reference: 24599548 - Blood. 2014 Apr 24;123(17):2691-702 – reference: 11222358 - Blood. 2001 Mar 1;97(5):1172-9 – reference: 19033363 - Nucleic Acids Res. 2009 Jan;37(1):1-13 – reference: 17923094 - Cell. 2007 Oct 5;131(1):146-59 – reference: 18940858 - Nucleic Acids Res. 2009 Jan;37(Database issue):D412-6 – reference: 11710998 - J Interferon Cytokine Res. 2001 Oct;21(10):851-60 – reference: 19727127 - Leukemia. 2009 Dec;23(12):2233-41 – reference: 23901108 - Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13576-81 – reference: 22880955 - Anal Chem. 2012 Sep 4;84(17):7469-78 – reference: 23676502 - J Clin Invest. 2013 Jun;123(6):2395-407 – reference: 20467426 - Nat Rev Immunol. 2010 Jun;10(6):387-402 – reference: 19782034 - Mol Cell. 2009 Sep 24;35(6):856-67 – reference: 24670665 - Nature. 2014 May 1;509(7498):49-54 – reference: 23850243 - Cell Stem Cell. 2013 Sep 5;13(3):285-99 – reference: 19095944 - Science. 2008 Dec 19;322(5909):1861-5 – reference: 17952086 - Nat Methods. 2007 Nov;4(11):923-5 – reference: 19110626 - Methods Mol Biol. 2009;506:159-69 – reference: 25017720 - Cell Stem Cell. 2014 Aug 7;15(2):227-38 – reference: 11031258 - J Biol Chem. 2001 Jan 26;276(4):2451-8 – reference: 17174120 - Immunity. 2006 Dec;25(6):977-88 – reference: 24525236 - Cancer Cell. 2014 Feb 10;25(2):226-42 – reference: 19339971 - Nature. 2009 May 21;459(7245):433-6 |
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| Snippet | We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an
in... We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in... |
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| Title | Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes |
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