Advances in mesenchymal stem cell exosomes: a review

Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regener...

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Bibliographic Details
Published in:Stem cell research & therapy Vol. 12; no. 1; pp. 71 - 12
Main Authors: Tang, Yaya, Zhou, Yan, Li, Hong-Jun
Format: Journal Article
Language:English
Published: London BioMed Central 19.01.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Acquisition methods
Antibodies
Antigens
Biological characteristics
Biological function
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Bone marrow
Cell Biology
Exosomes
Extracellular matrix
Immunogenicity
Life Sciences
Lipids
Medical research
Mesenchymal stem cells
Methods
Microenvironments
Paracrine signalling
Proteins
Regenerative medicine
Regenerative Medicine/Tissue Engineering
Review
Senescence
Stem cell research
Stem Cells
Tissue engineering
Transplantation
Umbilical cord
Biological function
Regenerative medicine
Clinical application
Acquisition methods
Biological characteristics
Exosomes
Mesenchymal stem cells
ISSN:1757-6512, 1757-6512
Online Access:Get full text
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Summary:Stem cells can be used for regenerative medicine and as treatments for disease. The application of tissue engineering-related transplantation, stem cells, and local changes in the microenvironment is expected to solve major medical problems. Currently, most studies focus on tissue repair and regeneration, and mesenchymal stem cells (MSCs) are among the most common research topics. MSCs are applicable as seed cells, and they represent one of the current hot topics in regenerative medicine research. However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted delivery, low immunogenicity, and high repairability. This article reviews the acquisition methods, characteristics, biological functions, and clinical applications of exosomes.
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ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02138-7