Modeling and predicting the overlap of B- and T-cell receptor repertoires in healthy and SARS-CoV-2 infected individuals

Adaptive immunity’s success relies on the extraordinary diversity of protein receptors on B and T cell membranes. Despite this diversity, the existence of public receptors shared by many individuals gives hope for developing population-wide vaccines and therapeutics. Using probabilistic modeling, we...

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Bibliographic Details
Published in:	PLoS genetics Vol. 19; no. 2; p. e1010652
Main Authors:	Ruiz Ortega, María, Spisak, Natanael, Mora, Thierry, Walczak, Aleksandra M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 24.02.2023 Public Library of Science (PLoS)
Subjects:	Adaptive immunity Analysis Antigens B cells Biology and life sciences Cell membranes Cell receptors Coronaviruses COVID-19 Health aspects Humans Learning models (Stochastic processes) Life Sciences Lymphocytes Lymphocytes T Medicine and Health Sciences Receptor mechanisms Receptors, Antigen, T-Cell Research and Analysis Methods SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 T cell receptors T cells T-Lymphocytes Vaccines France
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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