Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

Background Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related to systemic inflammation is still unsettled. While the implication of microglia...

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Bibliographic Details
Published in:	Immunity & Ageing Vol. 18; no. 1; pp. 29 - 25
Main Authors:	Munawara, Usma, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Bosco, Nabil, Dumoulin, David, Khalil, Abdelouahed, Larbi, Anis, Lévesque, Simon, Ramassamy, Charles, Barron, Annelise E., Cunnane, Stephen, Beauregard, Pascale B., Bellenger, Jean-Pierre, Rodrigues, Serafim, Desroches, Mathieu, Witkowski, Jacek M., Laurent, Benoit, Frost, Eric H., Fulop, Tamas
Format:	Journal Article
Language:	English
Published:	London Springer Science and Business Media LLC 21.06.2021 BioMed Central BioMed Central Ltd Springer Nature B.V BMC
Subjects:	[MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS] [SCCO.NEUR] Cognitive science/Neuroscience Advertising executives Aging Alzheimer's disease Analysis Antibodies Atherosclerosis Biomedical and Life Sciences Biomedicine Blood Brain research Cell activation Chemokines Chemotaxis Clinical Nutrition Cognitive ability Cognitive science Cytokines Dementia Dementia disorders Development and progression Dynamical Systems Free Radicals Geriatrics Geriatrics/Gerontology Hypotheses Immune response Immune system Immunity Immunologic diseases. Allergy Immunology Inflammation Innate immunity Instrument industry Macrophages Mathematical models Mathematics MCI Neuroinflammation Medical equipment and supplies industry Medical research Medical test kit industry Medicine, Experimental Memory Metabolism and Aging Microglia Monocytes Neurodegenerative diseases Neuropsychology Neuroscience Pathogenesis Patients Phagocytosis Phenotypes Public Health RC581-607 RC952-954.6 Signaling TLR2 protein TLR4 protein Toll-like receptors Canada United States monocytes phagocytosis macrophages free radicals MCI neuroinflammation signaling Alzheimer’s disease cytokines
ISSN:	1742-4933, 1742-4933
Online Access:	Get full text
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