miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming

Background Introduction of the transcription factors Oct4, Sox2, Klf4, and c-Myc (OSKM) is able to ‘reprogram’ somatic cells to become induced pluripotent stem cells (iPSCs). Several microRNAs (miRNAs) are known to enhance reprogramming efficiency when co-expressed with the OSKM factors. The primate...

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Bibliographic Details
Published in:	Stem cell research & therapy Vol. 8; no. 1; pp. 214 - 15
Main Authors:	Nguyen, Phan Nguyen Nhi, Choo, Kong Bung, Huang, Chiu-Jung, Sugii, Shigeki, Cheong, Soon Keng, Kamarul, Tunku
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.09.2017 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Alkaline phosphatase Apoptosis Biomedical and Life Sciences Biomedical Engineering and Bioengineering c-Myc protein C19MC Cancer Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cell cycle Cell death Cell Line, Tumor Cell proliferation Cell regulation Cellular Reprogramming Chromosome 19 Colonies Epithelial-Mesenchymal Transition Fibroblasts Gene expression Gene targeting Genetic aspects Genomes Health aspects Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Inhibitory postsynaptic potentials Kinases KLF4 protein Life Sciences Mesenchyme MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miR-524-5p miRNA Myc protein Oct-4 protein Phylogeny Pluripotency Pluripotency genes Polymerase chain reaction Prostate Proteins Regenerative Medicine/Tissue Engineering Reprogramming efficiency Smad4 protein Smad4 Protein - genetics Smad4 Protein - metabolism Somatic cells Stem cell transplantation Stem Cells Transcription factors Zinc Finger E-box Binding Homeobox 2 - genetics Zinc Finger E-box Binding Homeobox 2 - metabolism United States > US Cell proliferation miR-524-5p Pluripotency genes ZEB2 SMAD4 C19MC Reprogramming efficiency TP53INP1 MET Apoptosis
ISSN:	1757-6512, 1757-6512
Online Access:	Get full text
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