Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed ne...

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Bibliographic Details
Published in:	Journal of autism and developmental disorders Vol. 45; no. 11; pp. 3409 - 3423
Main Authors:	Richey, J. Anthony, Damiano, Cara R., Sabatino, Antoinette, Rittenberg, Alison, Petty, Chris, Bizzell, Josh, Voyvodic, James, Heller, Aaron S., Coffman, Marika C., Smoski, Moria, Davidson, Richard J., Dichter, Gabriel S.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.11.2015 Springer Springer Nature B.V
Subjects:	Adult Adults Amygdala Amygdala - physiopathology Anxiety Anxiety Disorders Autism Autism Spectrum Disorder - physiopathology Autism Spectrum Disorder - psychology Autism Spectrum Disorders Autistic children Behavior disorders Behavioral Science and Psychology Behavioral Sciences Brain Hemisphere Functions Brain research Care and treatment Case-Control Studies Child and School Psychology Cognitive ability Cognitive appraisal Comorbidity Coping Cortex Departments Development and progression Developmental Disabilities Disorders Emotion regulation Emotional distress Emotional Disturbances Emotional Problems Emotional regulation Emotional Response Emotional responses Emotions Emotions - physiology Etiology Externalizing problems Eye Movements Eye Movements - physiology Facial Expression Facial expressions Female Functional Neuroimaging Genetic aspects High functioning Humans Information Processing Internalization Magnetic Resonance Imaging Male Medical imaging Mental Disorders Neurosciences Nucleus accumbens Nucleus Accumbens - physiopathology Patient outcomes Pediatrics Pervasive Developmental Disorders Prefrontal cortex Prefrontal Cortex - physiopathology Psychiatry Psychological distress Psychological Patterns Psychology Public Health Pupil - physiology Resistance (Psychology) Risk factors Self Control Self-destructive behavior SI: Emotion Regulation and Psychiatric Comorbidity in ASD Subjectivity Young Adult United States New York United States > US Dorsolateral prefrontal cortex Nucleus accumbens Amygdala Eyetracking Emotion regulation Autism spectrum disorder
ISSN:	0162-3257, 1573-3432, 1573-3432
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Summary:	Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0162-3257 1573-3432 1573-3432
DOI:	10.1007/s10803-015-2359-z