Protein-altering germline mutations implicate novel genes related to lung cancer development
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for...
Uloženo v:
| Vydáno v: | Nature communications Ročník 11; číslo 1; s. 2220 - 14 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
Nature Publishing Group UK
11.05.2020
Nature Publishing Group Nature Portfolio |
| Témata: | |
| ISSN: | 2041-1723, 2041-1723 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an
ATM
L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82,
P
= 1.18 × 10
−15
) and replication (adjusted OR = 2.93,
P
= 2.22 × 10
−3
) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among
ATM
L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61,
P
= 7.98 × 10
−22
) and replication datasets (adjusted OR = 1.55,
P
= 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene,
KIAA0930
. Our findings implicate germline genetic variants in
ATM
with lung cancer susceptibility and suggest
KIAA0930
as a novel candidate gene for lung cancer risk.
In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk. |
|---|---|
| AbstractList | Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10
) and replication (adjusted OR = 2.93, P = 2.22 × 10
) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10
) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2.22 × 10−3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10−22) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk. Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10-15) and replication (adjusted OR = 2.93, P = 2.22 × 10-3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10-22) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk.Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10-15) and replication (adjusted OR = 2.93, P = 2.22 × 10-3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10-22) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10 −15 ) and replication (adjusted OR = 2.93, P = 2.22 × 10 −3 ) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10 −22 ) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930 . Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk. Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10 −15 ) and replication (adjusted OR = 2.93, P = 2.22 × 10 −3 ) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10 −22 ) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930 . Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio=8.82, P=1.18x10(-15)) and replication (adjusted OR=2.93, P=2.22x10(-3)) that is more pronounced in females (adjusted OR=6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR=2.61, P=7.98x10(-22)) and replication datasets (adjusted OR=1.55, P=0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk. Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2.22 × 10−3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10−22) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk. © 2020, The Author(s). |
| ArticleNumber | 2220 |
| Author | McLaughlin, John Gorlova, Olga Shepherd, Frances Goodman, Gary E. Chen, Chu Hellmann, Matthew D. Swiatkowska, Beata Davies, Michael P. A. Andrew, Angeline S. Schabath, Matthew B. Shete, Sanjay Song, Lei Tsao, Ming-Sound Risch, Angela Srinivasan, Preethi Woll, Penella Fernandez-Tardon, Guillermo Gorlov, Ivan Ji, Xuemei Han, Younghun Saliba, Walid Stadler, Zsofia K. Leighl, Natasha Kiemeney, Lambertus FA Ognjanovic, Simona Berger, Michael F. Robson, Mark E. Mukherjee, Semanti Albanes, Demetrios Christiani, David C. Offit, Kenneth Wichmann, Erich Haura, Eric B. Xiao, Xiangjun Bolca, Ciprian Lazarus, Philip Solit, David B. Holcatova, Ivana Timens, Wim Haiman, Christopher Carreras-Torres, Robert Johansson, Mattias Stevens, Victoria Le Marchand, Loic Landi, Maria Teresa Bush, William S. Bickeböller, Heike Aldrich, Melinda C. Bandlamudi, Chaitanya Taylor, Fiona Bakke, Per Johansson, Mikael Butler, Lesley M. Heijden, Erik H. F. M. van der Janout, Vladimir Joubert, Philippe Byun, Jinyoung Mukeria, Anush Melander, Olle Trichopoulou, Antonia Kontic, Milic |
| Author_xml | – sequence: 1 givenname: Xuemei orcidid: 0000-0001-7416-9122 surname: Ji fullname: Ji, Xuemei email: xuemei.ji@yahoo.com organization: Biomedical Data Science, Geisel School of Medicine at Dartmouth – sequence: 2 givenname: Semanti surname: Mukherjee fullname: Mukherjee, Semanti organization: Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 3 givenname: Maria Teresa surname: Landi fullname: Landi, Maria Teresa organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health – sequence: 4 givenname: Yohan orcidid: 0000-0002-3067-3711 surname: Bosse fullname: Bosse, Yohan organization: Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University – sequence: 5 givenname: Philippe surname: Joubert fullname: Joubert, Philippe organization: Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University – sequence: 6 givenname: Dakai surname: Zhu fullname: Zhu, Dakai organization: Biomedical Data Science, Geisel School of Medicine at Dartmouth, The Institute for Clinical and Translational Research, Baylor College of Medicine – sequence: 7 givenname: Ivan surname: Gorlov fullname: Gorlov, Ivan organization: Biomedical Data Science, Geisel School of Medicine at Dartmouth – sequence: 8 givenname: Xiangjun surname: Xiao fullname: Xiao, Xiangjun organization: The Institute for Clinical and Translational Research, Baylor College of Medicine – sequence: 9 givenname: Younghun surname: Han fullname: Han, Younghun organization: The Institute for Clinical and Translational Research, Baylor College of Medicine – sequence: 10 givenname: Olga surname: Gorlova fullname: Gorlova, Olga organization: Biomedical Data Science, Geisel School of Medicine at Dartmouth – sequence: 11 givenname: Rayjean J. orcidid: 0000-0002-4486-7496 surname: Hung fullname: Hung, Rayjean J. organization: Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto – sequence: 12 givenname: Yonathan surname: Brhane fullname: Brhane, Yonathan organization: Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto – sequence: 13 givenname: Robert surname: Carreras-Torres fullname: Carreras-Torres, Robert organization: International Agency for Research on Cancer, World Health Organization – sequence: 14 givenname: David C. orcidid: 0000-0002-0301-0242 surname: Christiani fullname: Christiani, David C. organization: Department of Environmental Health, Harvard T.H. Chan School of Public Health, Department of Medicine, Massachusetts General Hospital/Harvard – sequence: 15 givenname: Neil surname: Caporaso fullname: Caporaso, Neil organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health – sequence: 16 givenname: Mattias surname: Johansson fullname: Johansson, Mattias organization: International Agency for Research on Cancer, World Health Organization – sequence: 17 givenname: Geoffrey surname: Liu fullname: Liu, Geoffrey organization: Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto – sequence: 18 givenname: Stig E. orcidid: 0000-0002-4061-4133 surname: Bojesen fullname: Bojesen, Stig E. organization: Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen General Population Study, Herlev and Gentofte Hospital – sequence: 19 givenname: Loic surname: Le Marchand fullname: Le Marchand, Loic organization: Epidemiology Program, University of Hawaii Cancer Center – sequence: 20 givenname: Demetrios surname: Albanes fullname: Albanes, Demetrios organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health – sequence: 21 givenname: Heike surname: Bickeböller fullname: Bickeböller, Heike organization: Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen – sequence: 22 givenname: Melinda C. surname: Aldrich fullname: Aldrich, Melinda C. organization: Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center – sequence: 23 givenname: William S. orcidid: 0000-0002-9729-6519 surname: Bush fullname: Bush, William S. organization: Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University – sequence: 24 givenname: Adonina orcidid: 0000-0001-5150-1209 surname: Tardon fullname: Tardon, Adonina organization: IUOPA. University of Oviedo and CIBERESP, Faculty of Medicine, Campus del Cristo s/n – sequence: 25 givenname: Gad orcidid: 0000-0002-8512-068X surname: Rennert fullname: Rennert, Gad organization: Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine – sequence: 26 givenname: Chu surname: Chen fullname: Chen, Chu organization: Public Health Sciences Division, Fred Hutchinson Cancer Research Center – sequence: 27 givenname: Jinyoung surname: Byun fullname: Byun, Jinyoung organization: The Institute for Clinical and Translational Research, Baylor College of Medicine – sequence: 28 givenname: Konstantin H. surname: Dragnev fullname: Dragnev, Konstantin H. organization: The Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center – sequence: 29 givenname: John K. surname: Field fullname: Field, John K. organization: Roy Castle lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool – sequence: 30 givenname: Lambertus FA surname: Kiemeney fullname: Kiemeney, Lambertus FA organization: Radboud University Medical Center, Radboud Institute for Health Sciences – sequence: 31 givenname: Philip surname: Lazarus fullname: Lazarus, Philip organization: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University – sequence: 32 givenname: Shan surname: Zienolddiny fullname: Zienolddiny, Shan organization: National Institute of Occupational Health – sequence: 33 givenname: Stephen surname: Lam fullname: Lam, Stephen organization: British Columbia Cancer Agency – sequence: 34 givenname: Matthew B. orcidid: 0000-0003-3241-3216 surname: Schabath fullname: Schabath, Matthew B. organization: Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute – sequence: 35 givenname: Angeline S. surname: Andrew fullname: Andrew, Angeline S. organization: Department of Epidemiology, Geisel School of Medicine – sequence: 37 givenname: Angela C. orcidid: 0000-0002-0261-3252 surname: Pesatori fullname: Pesatori, Angela C. organization: Department of Preventive Medicine, IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan – sequence: 38 givenname: Nancy surname: Diao fullname: Diao, Nancy organization: Department of Environmental Health, Harvard T.H. Chan School of Public Health – sequence: 39 givenname: Li surname: Su fullname: Su, Li organization: Department of Environmental Health, Harvard T.H. Chan School of Public Health – sequence: 40 givenname: Lei surname: Song fullname: Song, Lei organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health – sequence: 41 givenname: Ruyang orcidid: 0000-0003-3861-4297 surname: Zhang fullname: Zhang, Ruyang organization: Department of Environmental Health, Harvard T.H. Chan School of Public Health – sequence: 42 givenname: Natasha surname: Leighl fullname: Leighl, Natasha organization: University Health Network- The Princess Margaret Cancer Centre – sequence: 44 givenname: Anders surname: Mellemgaard fullname: Mellemgaard, Anders organization: Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital – sequence: 45 givenname: Walid surname: Saliba fullname: Saliba, Walid organization: Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine – sequence: 46 givenname: Christopher surname: Haiman fullname: Haiman, Christopher organization: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center – sequence: 47 givenname: Lynne surname: Wilkens fullname: Wilkens, Lynne organization: Epidemiology Program, University of Hawaii Cancer Center – sequence: 48 givenname: Ana surname: Fernandez-Somoano fullname: Fernandez-Somoano, Ana organization: IUOPA. University of Oviedo and CIBERESP, Faculty of Medicine, Campus del Cristo s/n – sequence: 50 givenname: Erik H. F. M. van der orcidid: 0000-0003-3596-518X surname: Heijden fullname: Heijden, Erik H. F. M. van der organization: Radboud University Medical Center, Radboud Institute for Health Sciences – sequence: 51 givenname: Jin Hee orcidid: 0000-0003-1204-7079 surname: Kim fullname: Kim, Jin Hee organization: Department of Integrative Bioscience & Biotechnology, Sejong University – sequence: 52 givenname: Michael P. A. orcidid: 0000-0002-7609-4977 surname: Davies fullname: Davies, Michael P. A. organization: Roy Castle lung Cancer Research Programme, Institute of Translational Medicine, University of Liverpool – sequence: 54 givenname: Hans orcidid: 0000-0001-7402-138X surname: Brunnström fullname: Brunnström, Hans organization: Department of Pathology, Lund University – sequence: 55 givenname: Jonas surname: Manjer fullname: Manjer, Jonas organization: Faculty of Medicine, Lund University – sequence: 56 givenname: Olle surname: Melander fullname: Melander, Olle organization: Faculty of Medicine, Lund University – sequence: 57 givenname: David C. orcidid: 0000-0002-2350-0417 surname: Muller fullname: Muller, David C. organization: School of Public Health, St Mary’s Campus, Imperial College London – sequence: 58 givenname: Kim orcidid: 0000-0001-6429-7921 surname: Overvad fullname: Overvad, Kim organization: Faculty of Medicine, Lund University – sequence: 59 givenname: Antonia surname: Trichopoulou fullname: Trichopoulou, Antonia organization: Hellenic Health Foundation – sequence: 60 givenname: Rosario orcidid: 0000-0003-2666-414X surname: Tumino fullname: Tumino, Rosario organization: Cancer Registry and Histopathology Department, “Civic - M.P. Arezzo” Hospital – sequence: 61 givenname: Gary E. surname: Goodman fullname: Goodman, Gary E. organization: Fred Hutchinson Cancer Research Center, Swedish Medical Group – sequence: 62 givenname: Angela orcidid: 0000-0002-5138-1099 surname: Cox fullname: Cox, Angela organization: Department of Oncology and Metabolism, University of Sheffield – sequence: 63 givenname: Fiona surname: Taylor fullname: Taylor, Fiona organization: Department of Oncology and Metabolism, University of Sheffield – sequence: 64 givenname: Penella surname: Woll fullname: Woll, Penella organization: Department of Oncology and Metabolism, University of Sheffield – sequence: 65 givenname: Erich surname: Wichmann fullname: Wichmann, Erich organization: Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health – sequence: 66 givenname: Thomas orcidid: 0000-0002-8141-0604 surname: Muley fullname: Muley, Thomas organization: Thoraxklinik at University Hospital Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H) – sequence: 67 givenname: Angela orcidid: 0000-0002-8026-5505 surname: Risch fullname: Risch, Angela organization: University of Salzburg and Cancer Cluster Salzburg – sequence: 68 givenname: Albert orcidid: 0000-0001-7848-1332 surname: Rosenberger fullname: Rosenberger, Albert organization: Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen – sequence: 69 givenname: Kjell orcidid: 0000-0003-4289-2097 surname: Grankvist fullname: Grankvist, Kjell organization: Department of Medical Biosciences, Umeå University – sequence: 71 givenname: Frances surname: Shepherd fullname: Shepherd, Frances organization: Princess Margaret Cancer Centre – sequence: 72 givenname: Ming-Sound orcidid: 0000-0002-9160-5405 surname: Tsao fullname: Tsao, Ming-Sound organization: Princess Margaret Cancer Centre – sequence: 74 givenname: Eric B. surname: Haura fullname: Haura, Eric B. organization: Department of Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute – sequence: 75 givenname: Ciprian orcidid: 0000-0001-5480-4459 surname: Bolca fullname: Bolca, Ciprian organization: Institute of Pneumology “Marius Nasta” – sequence: 76 givenname: Ivana orcidid: 0000-0002-1366-0337 surname: Holcatova fullname: Holcatova, Ivana organization: Charles University, 1st Faculty of Medicine – sequence: 77 givenname: Vladimir surname: Janout fullname: Janout, Vladimir organization: Faculty of Health Sciences, Palacky University – sequence: 78 givenname: Milica surname: Kontic fullname: Kontic, Milica organization: Clinical Center of Serbia, Clinic for Pulmonology, School of Medicine, University of Belgrade – sequence: 79 givenname: Jolanta surname: Lissowska fullname: Lissowska, Jolanta organization: Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Institute – Oncology Center – sequence: 80 givenname: Anush orcidid: 0000-0002-6847-9295 surname: Mukeria fullname: Mukeria, Anush organization: Department of Epidemiology and Prevention, Russian N.N.Blokhin Cancer Research Centre – sequence: 81 givenname: Simona surname: Ognjanovic fullname: Ognjanovic, Simona organization: International Organization for Cancer Prevention and Research – sequence: 82 givenname: Tadeusz M. surname: Orlowski fullname: Orlowski, Tadeusz M. organization: Department of Surgery, National Tuberculosis and Lung Diseases Research Institute – sequence: 83 givenname: Ghislaine surname: Scelo fullname: Scelo, Ghislaine organization: International Agency for Research on Cancer, World Health Organization – sequence: 84 givenname: Beata surname: Swiatkowska fullname: Swiatkowska, Beata organization: Nofer Institute of Occupational Medicine, Department of Environmental Epidemiology – sequence: 86 givenname: Per surname: Bakke fullname: Bakke, Per organization: Department of Clinical Science, University of Bergen – sequence: 88 givenname: Lesley M. surname: Butler fullname: Butler, Lesley M. organization: University of Pittsburgh Cancer Institute – sequence: 89 givenname: Kenneth surname: Offit fullname: Offit, Kenneth organization: Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 90 givenname: Preethi surname: Srinivasan fullname: Srinivasan, Preethi organization: Department of Pathology, Memorial Sloan Kettering Cancer Center – sequence: 91 givenname: Chaitanya surname: Bandlamudi fullname: Bandlamudi, Chaitanya organization: Marie-Josée and Henry R. KravisCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center – sequence: 92 givenname: Matthew D. orcidid: 0000-0002-2670-9777 surname: Hellmann fullname: Hellmann, Matthew D. organization: Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 93 givenname: David B. surname: Solit fullname: Solit, David B. organization: Department of Medicine, Memorial Sloan Kettering Cancer Center, Marie-Josée and Henry R. KravisCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center – sequence: 94 givenname: Mark E. orcidid: 0000-0002-3109-1692 surname: Robson fullname: Robson, Mark E. organization: Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 95 givenname: Charles M. orcidid: 0000-0001-5204-3465 surname: Rudin fullname: Rudin, Charles M. organization: Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 96 givenname: Zsofia K. surname: Stadler fullname: Stadler, Zsofia K. organization: Department of Medicine, Memorial Sloan Kettering Cancer Center – sequence: 98 givenname: Michael F. surname: Berger fullname: Berger, Michael F. organization: Department of Pathology, Memorial Sloan Kettering Cancer Center, Marie-Josée and Henry R. KravisCenter for Molecular Oncology, Memorial Sloan Kettering Cancer Center – sequence: 99 givenname: Richard orcidid: 0000-0002-5268-0242 surname: Houlston fullname: Houlston, Richard organization: The Institute of Cancer Research – sequence: 100 givenname: John surname: McLaughlin fullname: McLaughlin, John organization: University of Toronto – sequence: 101 givenname: Victoria orcidid: 0000-0003-0259-4407 surname: Stevens fullname: Stevens, Victoria organization: American Cancer Society, Inc – sequence: 102 givenname: David C. surname: Nickle fullname: Nickle, David C. organization: Merck Research Laboratories, Genetics and Pharmacogenomics – sequence: 103 givenname: Ma’en orcidid: 0000-0002-5443-2752 surname: Obeidat fullname: Obeidat, Ma’en organization: The University of British Columbia Centre for Heart Lung Innovation, St Paul’s Hospital – sequence: 104 givenname: Wim orcidid: 0000-0002-4146-6363 surname: Timens fullname: Timens, Wim organization: University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, GRIAC research institute – sequence: 106 givenname: Sanjay surname: Shete fullname: Shete, Sanjay organization: Department of Biostatistics, The University of Texas MD Anderson Cancer Center – sequence: 107 givenname: Hermann surname: Brenner fullname: Brenner, Hermann organization: Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) – sequence: 108 givenname: Stephen orcidid: 0000-0002-2324-3393 surname: Chanock fullname: Chanock, Stephen organization: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health – sequence: 110 givenname: James D. surname: McKay fullname: McKay, James D. organization: International Agency for Research on Cancer, World Health Organization – sequence: 111 givenname: Christopher I. orcidid: 0000-0002-8540-7023 surname: Amos fullname: Amos, Christopher I. email: chrisa@bcm.edu organization: The Institute for Clinical and Translational Research, Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32393777$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174634$$DView record from Swedish Publication Index (Umeå universitet) |
| BookMark | eNp9kktv1DAUhSNUREvpH2CBIrFhE_Arsb1BqsqrUiVYACsky3Fuph45drCTIv49zmQonUo0G0f2d4_PvT5PiyMfPBTFc4xeY0TFm8Qwa3iFCKpwLVFdNY-KE4IYrjAn9OjO_3FxltIW5Y9KLBh7UhxTQiXlnJ8UP77EMIH1lXYTROs35Qbi4KyHcpgnPdngU2mH0VmjJyh9uAGXEQ-pjODyVldOoXRzLjTaG4hlBxkJ4wB-elY87rVLcLZfT4tvH95_vfhUXX3-eHlxflUZTtlUyRqZ2tSYCNPy3hiNAHAvGLBaQwNdDb0hwFrW10zKHteEU01NC63QiJOGnhaXq24X9FaN0Q46_lZBW7XbCHGjdJyscaCk6No6a7YEdQwT2grCGMKiloZRoduspVet9AvGuT1QG0OctFMREuhorpWbVQKVqd10llEp6CRmFEklcxeKdZQqzThTtBNSA5a0bxe_1X_veGe_n-8cz8OsMGcNZZl_u_IZHqAzebQx-ziwdnDi7bXahBvFCc7d8Szwai8Qw88Z0qQGmww4pz2EOSmyjAAJhhdvL--h2zBHn59vRyHWILk4enHX0a2Vv8HKAFkBE0NKEfpbBCO1BFitAVY5wGoXYLXcLe4VGbtmMHdl3cOldD_ScUkxxH-2H6j6A544B2k |
| CitedBy_id | crossref_primary_10_1111_bjh_18419 crossref_primary_10_1164_rccm_202212_2199OC crossref_primary_10_1200_EDBK_389956 crossref_primary_10_2217_pgs_2020_0150 crossref_primary_10_1093_jnci_djac087 crossref_primary_10_1016_S2213_2600_24_00124_3 crossref_primary_10_3390_ijms26083818 crossref_primary_10_1016_j_critrevonc_2023_104058 crossref_primary_10_1038_s41571_023_00844_0 crossref_primary_10_1038_s41588_023_01553_1 crossref_primary_10_1002_cm_21878 crossref_primary_10_3390_cancers13092024 crossref_primary_10_1038_s41588_022_01115_x crossref_primary_10_1002_1878_0261_13548 crossref_primary_10_1200_EDBK_25_473778 crossref_primary_10_3389_fgene_2023_1141058 crossref_primary_10_1183_16000617_0045_2021 crossref_primary_10_3324_haematol_2024_286031 crossref_primary_10_1186_s12885_024_12014_1 crossref_primary_10_3390_cells9112409 crossref_primary_10_1016_j_cllc_2023_01_005 crossref_primary_10_1016_j_isci_2023_106426 crossref_primary_10_1186_s13073_022_01041_x crossref_primary_10_1016_j_jtho_2020_08_017 crossref_primary_10_1038_s41698_021_00146_7 crossref_primary_10_1038_s41431_023_01465_y crossref_primary_10_1016_j_gim_2023_100846 crossref_primary_10_1093_hmg_ddac140 crossref_primary_10_3390_ijms23105770 crossref_primary_10_1016_j_jtho_2023_05_028 |
| Cites_doi | 10.1038/nature07423 10.1038/ng.3892 10.1001/jama.2014.12483 10.1056/NEJMoa1612674 10.1158/1055-9965.EPI-16-0106 10.1016/j.cell.2018.03.039 10.1038/nbt1012 10.1093/nar/gkr996 10.1093/carcin/bgv165 10.1073/pnas.191502998 10.1093/annonc/mdt573 10.1371/journal.pone.0082769 10.1016/j.neo.2017.05.002 10.4161/cbt.6.3.3994 10.3322/caac.21387 10.1097/JTO.0000000000000130 10.1038/nmeth0410-248 10.3322/caac.21408 10.1038/s41588-018-0202-0 10.1002/art.1780341112 10.1038/s41467-018-05074-y 10.1056/NEJMra072367 10.1186/s12864-017-4166-8 10.1586/era.09.12 10.1038/nrdp.2015.9 10.1001/jama.2015.17703 10.1056/NEJMoa070608 10.1101/cshperspect.a012716 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| CorporateAuthor | LUCC: Lunds universitets cancercentrum Övriga starka forskningsmiljöer Section V Patologi, Lund Pathology, Lund Kardiovaskulär forskning - hypertoni Department of Clinical Sciences, Lund Strategiska forskningsområden (SFO) Surgery LUCC: Lund University Cancer Centre Medicinska fakulteten Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga Institutionen för kliniska vetenskaper, Lund Profile areas and other strong research environments Lunds universitet Department of Clinical Sciences, Malmö Lund University Improved diagnostics and prognostics of lung cancer and metastases to the lungs Sektion V Kirurgi Other Strong Research Environments EpiHealth: Epidemiology for Health EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Strategic research areas (SRA) Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö Cardiovascular Research - Hypertension |
| CorporateAuthor_xml | – name: Övriga starka forskningsmiljöer – name: Strategiska forskningsområden (SFO) – name: LUCC: Lund University Cancer Centre – name: EpiHealth: Epidemiology for Health – name: Strategic research areas (SRA) – name: Department of Clinical Sciences, Lund – name: Lund University – name: Improved diagnostics and prognostics of lung cancer and metastases to the lungs – name: EXODIAB: Excellence of Diabetes Research in Sweden – name: Sektion V – name: Profile areas and other strong research environments – name: Section V – name: Department of Clinical Sciences, Malmö – name: Faculty of Medicine – name: Medicinska fakulteten – name: Cardiovascular Research - Hypertension – name: Kardiovaskulär forskning - hypertoni – name: Other Strong Research Environments – name: Patologi, Lund – name: Institutionen för kliniska vetenskaper, Lund – name: Institutionen för kliniska vetenskaper, Malmö – name: Kirurgi – name: Surgery – name: Lunds universitet – name: Profilområden och andra starka forskningsmiljöer – name: Pathology, Lund – name: Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga – name: LUCC: Lunds universitets cancercentrum |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM ADHXS ADTPV AOWAS D8T D93 ZZAVC AGCHP D95 DOA |
| DOI | 10.1038/s41467-020-15905-6 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SWEPUB Umeå universitet full text SwePub SwePub Articles SWEPUB Freely available online SWEPUB Umeå universitet SwePub Articles full text SWEPUB Lunds universitet full text SWEPUB Lunds universitet Open Access: DOAJ - Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 14 |
| ExternalDocumentID | oai_doaj_org_article_98db56edb20d4123b824401859c438ab oai_portal_research_lu_se_publications_ed914309_9a0e_4d33_a474_3d89ae193fb6 oai_DiVA_org_umu_174634 PMC7214407 32393777 10_1038_s41467_020_15905_6 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: National Institutes of Health (NIH) for the research of lung cancer (grant P30CA023108 and P20GM103534); Transdisciplinary Research in Cancer of the Lung (TRICL) (grant U19CA148127) and Integral (U19CA203654). – fundername: Union for International Cancer Control (UICC) funderid: https://doi.org/10.13039/100010260 – fundername: Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) grantid: RR170048 funderid: https://doi.org/10.13039/100004917 – fundername: Department of Health – fundername: NCI NIH HHS grantid: P50 CA119997 – fundername: NCI NIH HHS grantid: P30 CA033572 – fundername: NCI NIH HHS grantid: R01 CA092824 – fundername: Cancer Research UK grantid: 24390 – fundername: NCI NIH HHS grantid: K07 CA172294 – fundername: NCI NIH HHS grantid: P30 CA023108 – fundername: Wellcome Trust grantid: 202849/Z/16/Z – fundername: NCI NIH HHS grantid: U01 CA209414 – fundername: NCATS NIH HHS grantid: UL1 TR000445 – fundername: ; – fundername: ; grantid: RR170048 |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM 4.4 ADHXS ADTPV AOWAS BAPOH CAG COF D8T D93 EJD LGEZI LOTEE NADUK NXXTH ZZAVC AGCHP D95 |
| ID | FETCH-LOGICAL-c734t-950c5c5128cb7fcca0ee1f84e45ae6ed5efc2e4b4f5499f15273a3cbeb8a07263 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 35 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000558695400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2041-1723 |
| IngestDate | Fri Oct 03 12:39:19 EDT 2025 Sat Nov 01 14:37:47 EDT 2025 Tue Nov 04 16:38:03 EST 2025 Tue Nov 04 02:05:38 EST 2025 Thu Oct 02 06:15:31 EDT 2025 Sat Nov 29 14:51:35 EST 2025 Mon Jul 21 06:06:28 EDT 2025 Tue Nov 18 22:34:21 EST 2025 Sat Nov 29 06:20:22 EST 2025 Fri Feb 21 02:40:10 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c734t-950c5c5128cb7fcca0ee1f84e45ae6ed5efc2e4b4f5499f15273a3cbeb8a07263 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-6847-9295 0000-0002-4061-4133 0000-0001-5150-1209 0000-0002-2324-3393 0000-0001-7402-138X 0000-0001-5480-4459 0000-0002-3067-3711 0000-0001-7416-9122 0000-0002-7609-4977 0000-0002-9729-6519 0000-0003-3241-3216 0000-0002-8141-0604 0000-0003-0259-4407 0000-0001-6429-7921 0000-0001-7848-1332 0000-0002-5443-2752 0000-0002-8512-068X 0000-0002-4486-7496 0000-0002-8540-7023 0000-0003-1204-7079 0000-0002-5268-0242 0000-0002-0301-0242 0000-0003-2666-414X 0000-0002-5138-1099 0000-0002-9160-5405 0000-0003-3596-518X 0000-0002-2350-0417 0000-0002-3109-1692 0000-0002-8026-5505 0000-0003-3861-4297 0000-0002-1366-0337 0000-0001-5204-3465 0000-0002-4146-6363 0000-0002-0261-3252 0000-0003-4289-2097 0000-0002-2670-9777 0000-0001-6542-9551 0000-0002-3355-9471 0000-0002-0518-8714 0000-0002-1470-1516 0000-0002-7680-158X |
| OpenAccessLink | https://www.proquest.com/docview/2401046094?pq-origsite=%requestingapplication% |
| PMID | 32393777 |
| PQID | 2401046094 |
| PQPubID | 546298 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_98db56edb20d4123b824401859c438ab swepub_primary_oai_portal_research_lu_se_publications_ed914309_9a0e_4d33_a474_3d89ae193fb6 swepub_primary_oai_DiVA_org_umu_174634 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7214407 proquest_miscellaneous_2401808416 proquest_journals_2401046094 pubmed_primary_32393777 crossref_primary_10_1038_s41467_020_15905_6 crossref_citationtrail_10_1038_s41467_020_15905_6 springer_journals_10_1038_s41467_020_15905_6 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-05-11 |
| PublicationDateYYYYMMDD | 2020-05-11 |
| PublicationDate_xml | – month: 05 year: 2020 text: 2020-05-11 day: 11 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Fernandez-Escamilla, Rousseau, Schymkowitz, Serrano (CR30) 2004; 22 Begam, Jamil, Raju (CR17) 2017; 18 Siegel, Miller, Jemal (CR1) 2017; 67 Yu (CR7) 2014; 25 Roukos, Murray, Briasoulis (CR4) 2007; 6 CR13 CR12 Adzhubei (CR15) 2010; 7 Bhattacharjee (CR18) 2001; 98 Gridelli (CR20) 2015; 1 Byun (CR28) 2017; 18 Croce (CR19) 2008; 358 Rennert (CR22) 2007; 357 McKay (CR3) 2017; 49 Ding (CR26) 2008; 455 Mucci (CR2) 2016; 315 Kim, Choi, Min, Kim, Kim (CR24) 2013; 8 King, Levy-Lahad, Lahad (CR23) 2014; 312 Chandrashekar (CR31) 2017; 19 Huang (CR25) 2018; 173 Zvidi (CR16) 2019; 21 Gazdar (CR6) 2014; 9 Ji (CR27) 2018; 9 De Baets (CR14) 2012; 40 Turnbull, Sud, Houlston (CR10) 2018; 50 Kachuri (CR11) 2016; 37 Roukos (CR5) 2009; 9 Wallin, Hillert, Olerup, Carlsson, Strom (CR21) 1991; 34 Amos (CR29) 2017; 26 Mok (CR8) 2017; 376 Hoskins, Gotlieb (CR9) 2017; 67 C Turnbull (15905_CR10) 2018; 50 15905_CR13 G Rennert (15905_CR22) 2007; 357 15905_CR12 DH Roukos (15905_CR5) 2009; 9 L Kachuri (15905_CR11) 2016; 37 CM Croce (15905_CR19) 2008; 358 MC King (15905_CR23) 2014; 312 HS Kim (15905_CR24) 2013; 8 L Ding (15905_CR26) 2008; 455 TS Mok (15905_CR8) 2017; 376 AM Fernandez-Escamilla (15905_CR30) 2004; 22 KL Huang (15905_CR25) 2018; 173 IA Adzhubei (15905_CR15) 2010; 7 I Zvidi (15905_CR16) 2019; 21 DS Chandrashekar (15905_CR31) 2017; 19 DH Roukos (15905_CR4) 2007; 6 J Wallin (15905_CR21) 1991; 34 HA Yu (15905_CR7) 2014; 25 PJ Hoskins (15905_CR9) 2017; 67 LA Mucci (15905_CR2) 2016; 315 JD McKay (15905_CR3) 2017; 49 A Bhattacharjee (15905_CR18) 2001; 98 CI Amos (15905_CR29) 2017; 26 G De Baets (15905_CR14) 2012; 40 N Begam (15905_CR17) 2017; 18 X Ji (15905_CR27) 2018; 9 J Byun (15905_CR28) 2017; 18 A Gazdar (15905_CR6) 2014; 9 C Gridelli (15905_CR20) 2015; 1 RL Siegel (15905_CR1) 2017; 67 |
| References_xml | – volume: 455 start-page: 1069 year: 2008 end-page: 1075 ident: CR26 article-title: Somatic mutations affect key pathways in lung adenocarcinoma publication-title: Nature doi: 10.1038/nature07423 – volume: 49 start-page: 1126 year: 2017 end-page: 1132 ident: CR3 article-title: Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes publication-title: Nat. Genet. doi: 10.1038/ng.3892 – volume: 312 start-page: 1091 year: 2014 end-page: 1092 ident: CR23 article-title: Population-based screening for BRCA1 and BRCA2: 2014 Lasker Award publication-title: JAMA doi: 10.1001/jama.2014.12483 – ident: CR12 – volume: 376 start-page: 629 year: 2017 end-page: 640 ident: CR8 article-title: Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1612674 – volume: 26 start-page: 126 year: 2017 end-page: 135 ident: CR29 article-title: The OncoArray Consortium: a network for understanding the genetic architecture of common cancers publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.EPI-16-0106 – volume: 21 start-page: 194 year: 2019 end-page: 197 ident: CR16 article-title: The incidence and prevalence of inflammatory bowel disease in the Jewish and Arab populations of Israel publication-title: Isr. Med. Assoc. J. – volume: 173 start-page: 355 year: 2018 end-page: 370.e14 ident: CR25 article-title: Pathogenic germline variants in 10,389 adult cancers publication-title: Cell doi: 10.1016/j.cell.2018.03.039 – volume: 22 start-page: 1302 year: 2004 end-page: 1306 ident: CR30 article-title: Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins publication-title: Nat. Biotechnol. doi: 10.1038/nbt1012 – volume: 40 start-page: D935 year: 2012 end-page: D939 ident: CR14 article-title: SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr996 – volume: 37 start-page: 96 year: 2016 end-page: 105 ident: CR11 article-title: Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci publication-title: Carcinogenesis doi: 10.1093/carcin/bgv165 – volume: 98 start-page: 13790 year: 2001 end-page: 13795 ident: CR18 article-title: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.191502998 – volume: 25 start-page: 423 year: 2014 end-page: 428 ident: CR7 article-title: Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing publication-title: Ann. Oncol. doi: 10.1093/annonc/mdt573 – volume: 8 start-page: e82769 year: 2013 ident: CR24 article-title: Mutation at intronic repeats of the ataxia-telangiectasia mutated (ATM) gene and ATM protein loss in primary gastric cancer with microsatellite instability publication-title: PLoS ONE doi: 10.1371/journal.pone.0082769 – volume: 19 start-page: 649 year: 2017 end-page: 658 ident: CR31 article-title: UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses publication-title: Neoplasia doi: 10.1016/j.neo.2017.05.002 – volume: 6 start-page: 308 year: 2007 end-page: 312 ident: CR4 article-title: Molecular genetic tools shape a roadmap towards a more accurate prognostic prediction and personalized management of cancer publication-title: Cancer Biol. Ther. doi: 10.4161/cbt.6.3.3994 – volume: 67 start-page: 7 year: 2017 end-page: 30 ident: CR1 article-title: Cancer Statistics, 2017 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21387 – volume: 9 start-page: 456 year: 2014 end-page: 463 ident: CR6 article-title: Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations publication-title: J. Thorac. Oncol. doi: 10.1097/JTO.0000000000000130 – volume: 7 start-page: 248 year: 2010 end-page: 249 ident: CR15 article-title: A method and server for predicting damaging missense mutations publication-title: Nat. Methods doi: 10.1038/nmeth0410-248 – volume: 67 start-page: 493 year: 2017 end-page: 506 ident: CR9 article-title: Missed therapeutic and prevention opportunities in women with BRCA-mutated epithelial ovarian cancer and their families due to low referral rates for genetic counseling and BRCA testing: A review of the literature publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21408 – volume: 50 start-page: 1212 year: 2018 end-page: 1218 ident: CR10 article-title: Cancer genetics, precision prevention and a call to action publication-title: Nat. Genet. doi: 10.1038/s41588-018-0202-0 – volume: 18 start-page: 3003 year: 2017 end-page: 3009 ident: CR17 article-title: Promoter hypermethylation of the ATM gene as a novel biomarker for breast cancer publication-title: Asian Pac. J. Cancer Prev. – ident: CR13 – volume: 34 start-page: 1416 year: 1991 end-page: 1424 ident: CR21 article-title: Association of rheumatoid arthritis with a dominant DR1/Dw4/Dw14 sequence motif, but not with T cell receptor beta chain gene alleles or haplotypes publication-title: Arthritis Rheum. doi: 10.1002/art.1780341112 – volume: 9 year: 2018 ident: CR27 article-title: Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk publication-title: Nat. Commun. doi: 10.1038/s41467-018-05074-y – volume: 358 start-page: 502 year: 2008 end-page: 511 ident: CR19 article-title: Oncogenes and cancer publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra072367 – volume: 18 year: 2017 ident: CR28 article-title: Ancestry inference using principal component analysis and spatial analysis: a distance-based analysis to account for population substructure publication-title: BMC Genomics doi: 10.1186/s12864-017-4166-8 – volume: 9 start-page: 389 year: 2009 end-page: 392 ident: CR5 article-title: Genome-wide association studies: how predictable is a person’s cancer risk? publication-title: Expert Rev. Anticancer Ther. doi: 10.1586/era.09.12 – volume: 1 start-page: 15009 year: 2015 ident: CR20 article-title: Non-small-cell lung cancer publication-title: Nat. Rev. Dis. Prim. doi: 10.1038/nrdp.2015.9 – volume: 315 start-page: 68 year: 2016 end-page: 76 ident: CR2 article-title: Familial risk and heritability of cancer among twins in Nordic countries publication-title: JAMA doi: 10.1001/jama.2015.17703 – volume: 357 start-page: 115 year: 2007 end-page: 123 ident: CR22 article-title: Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa070608 – volume: 49 start-page: 1126 year: 2017 ident: 15905_CR3 publication-title: Nat. Genet. doi: 10.1038/ng.3892 – ident: 15905_CR13 doi: 10.1101/cshperspect.a012716 – volume: 34 start-page: 1416 year: 1991 ident: 15905_CR21 publication-title: Arthritis Rheum. doi: 10.1002/art.1780341112 – volume: 1 start-page: 15009 year: 2015 ident: 15905_CR20 publication-title: Nat. Rev. Dis. Prim. doi: 10.1038/nrdp.2015.9 – volume: 357 start-page: 115 year: 2007 ident: 15905_CR22 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa070608 – volume: 67 start-page: 7 year: 2017 ident: 15905_CR1 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21387 – volume: 18 start-page: 3003 year: 2017 ident: 15905_CR17 publication-title: Asian Pac. J. Cancer Prev. – volume: 22 start-page: 1302 year: 2004 ident: 15905_CR30 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1012 – volume: 40 start-page: D935 year: 2012 ident: 15905_CR14 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr996 – volume: 173 start-page: 355 year: 2018 ident: 15905_CR25 publication-title: Cell doi: 10.1016/j.cell.2018.03.039 – volume: 455 start-page: 1069 year: 2008 ident: 15905_CR26 publication-title: Nature doi: 10.1038/nature07423 – volume: 67 start-page: 493 year: 2017 ident: 15905_CR9 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21408 – volume: 9 year: 2018 ident: 15905_CR27 publication-title: Nat. Commun. doi: 10.1038/s41467-018-05074-y – volume: 6 start-page: 308 year: 2007 ident: 15905_CR4 publication-title: Cancer Biol. Ther. doi: 10.4161/cbt.6.3.3994 – volume: 26 start-page: 126 year: 2017 ident: 15905_CR29 publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.EPI-16-0106 – volume: 9 start-page: 389 year: 2009 ident: 15905_CR5 publication-title: Expert Rev. Anticancer Ther. doi: 10.1586/era.09.12 – volume: 25 start-page: 423 year: 2014 ident: 15905_CR7 publication-title: Ann. Oncol. doi: 10.1093/annonc/mdt573 – volume: 21 start-page: 194 year: 2019 ident: 15905_CR16 publication-title: Isr. Med. Assoc. J. – volume: 98 start-page: 13790 year: 2001 ident: 15905_CR18 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.191502998 – ident: 15905_CR12 – volume: 315 start-page: 68 year: 2016 ident: 15905_CR2 publication-title: JAMA doi: 10.1001/jama.2015.17703 – volume: 358 start-page: 502 year: 2008 ident: 15905_CR19 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra072367 – volume: 9 start-page: 456 year: 2014 ident: 15905_CR6 publication-title: J. Thorac. Oncol. doi: 10.1097/JTO.0000000000000130 – volume: 19 start-page: 649 year: 2017 ident: 15905_CR31 publication-title: Neoplasia doi: 10.1016/j.neo.2017.05.002 – volume: 7 start-page: 248 year: 2010 ident: 15905_CR15 publication-title: Nat. Methods doi: 10.1038/nmeth0410-248 – volume: 18 year: 2017 ident: 15905_CR28 publication-title: BMC Genomics doi: 10.1186/s12864-017-4166-8 – volume: 50 start-page: 1212 year: 2018 ident: 15905_CR10 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0202-0 – volume: 312 start-page: 1091 year: 2014 ident: 15905_CR23 publication-title: JAMA doi: 10.1001/jama.2014.12483 – volume: 37 start-page: 96 year: 2016 ident: 15905_CR11 publication-title: Carcinogenesis doi: 10.1093/carcin/bgv165 – volume: 376 start-page: 629 year: 2017 ident: 15905_CR8 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa1612674 – volume: 8 start-page: e82769 year: 2013 ident: 15905_CR24 publication-title: PLoS ONE doi: 10.1371/journal.pone.0082769 |
| SSID | ssj0000391844 |
| Score | 2.4781196 |
| Snippet | Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and... In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel... |
| SourceID | doaj swepub pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2220 |
| SubjectTerms | 38 45/43 631/114 631/208 631/67 Adenocarcinoma Adenocarcinoma - genetics Aged Alleles Ataxia Telangiectasia Mutated Proteins - genetics Basic Medicine Databases, Genetic Female Gene expression Genetic diversity Genetic Predisposition to Disease Genetic variance Genotyping Techniques Germ-Line Mutation Health risk assessment Health risks Heterozygosity Heterozygote Humanities and Social Sciences Humans Jews - genetics Loss of heterozygosity Lung cancer Lung Neoplasms - genetics Male Medical and Health Sciences Medical Genetics and Genomics (including Gene Therapy) Medicin och hälsovetenskap Medicinsk genetik och genomik (Här ingår: Genterapi) Medicinska och farmaceutiska grundvetenskaper Middle Aged multidisciplinary Mutation Mutation, Missense Odds Ratio Oligonucleotide Array Sequence Analysis Pedigree Population genetics Replication Risk analysis Risk Factors RNA-Seq Science Science (multidisciplinary) Tumors White People - genetics |
| SummonAdditionalLinks | – databaseName: Open Access: DOAJ - Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQBRIXxJtAQUZCXCCqN3Zi-1geFQdU9QBVhZAsP9VIu9lqs6nEv2dsZ9NdqMqFazJJ7JnxPDL2Nwi9qR0VtfN1WRndlPEsYymkMGUVaMPlzFRNAtM5_cqPj8XZmTzZavUV94RleODMuAMpnKkb70xFHAMzawQ4JAJeRlpGhTbR-hIut5KpZIOphNSFjadkCBUHPUs2IWZL4MFJXTY7nigB9l8XZf69WXKqmP6BLpo80tF9dG8MJfFhnsIDdMt3D9Gd3Fzy1yP08yRCMLRdmQri8CoML1vEqBIvhlyA73E7bij3uFte-jmQgOnD6YCLd3i9xHMwBthG1Vhhd7XB6DH6fvT528cv5dhLobScsnUpa2JrC95dWMMDiI14PwuCeVZrD-ytfbCVZ4aFmDCG2OyWamqNN0ITDhJ7gva6ZeefIew4bZwONjgH4QzwlnqpA8jAOi1NxQo02_BV2RFoPPa7mKtU8KZCZVkokIVKslBNgd5Nz1xkmI0bqT9EcU2UESI7XQDFUaPiqH8pToH2N8JW47rtFcQ3segNOW-BXk-3YcXFMoru_HLINILEcm2BnmbdmEZCI6Ic57xAfEdrdoa6e6drzxOqN4_gdQSefL_Rr6th3cSKt1kHd77wqT09TMwYFoOCnLOhMJ8f1xDmHE-NwFLnaj6o3quLrT_GyjsJMTWRSoLOKOYoVZpxpqgTUnuI_4Npnv8PgbxAd6u4PCM07mwf7a1Xg3-JbtvLdduvXqX1_RsSnlTv priority: 102 providerName: Directory of Open Access Journals |
| Title | Protein-altering germline mutations implicate novel genes related to lung cancer development |
| URI | https://link.springer.com/article/10.1038/s41467-020-15905-6 https://www.ncbi.nlm.nih.gov/pubmed/32393777 https://www.proquest.com/docview/2401046094 https://www.proquest.com/docview/2401808416 https://pubmed.ncbi.nlm.nih.gov/PMC7214407 https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174634 https://doaj.org/article/98db56edb20d4123b824401859c438ab |
| Volume | 11 |
| WOSCitedRecordID | wos000558695400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological science database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection (Proquest) customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfYBhIvfMMCowoS4gWipbET209og00gQRUhmMqEZPkrrFKbdE0zif-es5OmFKa-8JKH2FFs3_k-fOffIfQyNZilxqZRomQWubuMEeNMRUmBM8qHKsk8mM7ZJzoasfGY592BW92lVa5kohfUptLujPwQNI8LR4I38nZ-GbmqUS662pXQ2EF7DiUh8al7eX_G4tDPGSHdXZkYs8OaeMngfCbQ43EaZRv6yMP2X2dr_psy2cdN_8IY9Xrp9O7_zugeutNZpOFRy0L30Q1bPkC32hqVvx6iH7lDcpiUkY-rw1hCGM3MGafhrGnj-HU46fLSbVhWV3YKXUCChv6ejDXhsgqnIFNC7ThsEZp1ntIj9O305Ou7D1FXkiHSFJNlxNNYpxqMBKYVLYD6sbXDghFLUmkza1Jb6MQSRQrndxauZi6WWCurmIwpEP4x2i2r0u6j0FCcGVnowhiwioA42HJZxJRrI7lKSICGK8II3eGVu7IZU-Hj5piJlpgCiCk8MUUWoNf9N_MWrWNr72NH776nQ9r2L6rFT9FtXMGZUSnMTCWxIaDmFQODKAYrh2uCmVQBOlhRV3TbvxZr0gboRd8MG9dFY2Rpq6btw2IX9Q3Qk5a5-pFgB0xHKQ0Q3WC7jaFutpSTCw8OTh0GXgxfvlkx6HpY25biVcvEG394Pzk78ovRzBoBrmuGYT7n13RsXUXR4VNdiGkjaivmfxw8C2s4mOYxFxx4RhCDsZCEEoEN49KCG1Go7On2tXyGbidu5zrs3OEB2l0uGvsc3dRXy0m9GKAdOqb-yQZo7_hklH8Z-BOWgRcK8MzTc2jJP37Ov_8GcRhqnQ |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELdGB4IXvj8CA4wEvEC0NHZi-wGhwZhWrZv6MKYNIZn4I6xSm5SmGdo_xd_IOUlTClPf9sBr47Q-93fnO9_5dwi9jAzhkbGRH6ok9t1dRp8LrvwwJTETXRXGFZnOUZ8dHPDjYzFYQ7_md2FcWeXcJlaG2uTanZFvws7j0pEQjbyf_PBd1yiXXZ230KhhsWfPf0LIVrzrbcP_-yoMdz4dftz1m64CvmaEznwRBTrSsM9xrVgKAgTWdlNOLY0SG1sT2VSHliqautApdW1fSUK0soonAYO5w_deQevUgb2D1ge9_cFJe6rj-NY5pc3tnIDwzYJWtshFaeA5BJEfL-2AVaOAi7zbf4s020ztX6ym1U64c-t_W8Pb6Gbjc-OtWknuoDWb3UXX6i6c5_fQ14HjqhhmflU5ALJjkH7s3G88LutKhQIPm8p7i7P8zI5gCOwRuLoJZA2e5XgEVhNrp0NTbBaVWPfR50sR7QHqZHlmHyFsGIlNkurUGPD7AAzEiiQNmNAmESqkHurOgSB1w8juGoOMZFUZQLiswSMBPLICj4w99KZ9Z1Lzkawc_cHhqx3puMSrD_Lpd9mYJim4URFIpsLAUHBkFAeXLwA_TmhKeKI8tDFHk2wMXCEXUPLQi_YxmCaXb0oym5f1GB64vLaHHtZgbmdCHPUeY8xDbAnmS1NdfpINTyv6c-ZY_gJ48-1cIRbTWrUUr2ulWfqF7eHRVrUY5biUEJzHBOT5csHAOhiWDQPXqRyVsrBy8sfRurRGQPARCCkAM5IaQmRCGZXEcJFYCJRSFT9evZbP0fXdw_2-7PcO9p6gG6GzGo4puLuBOrNpaZ-iq_psNiymzxrDg9G3y9bT37JqxIc |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lj9MwELaW5SEuvB-BBYIEXCBqGjuxfUBooVSsdlX1AKvVCsnEj7CV2qQ0zaL9a_w6xs6jFFa97YFr47Se6TfjGXv8DUIvYo1ZrE0cRDJNAnuXMWCcySDKcEJ5X0aJI9M5PKCjETs64uMt9Ku9C2PLKluf6By1LpTdI-_BymOPIyEb6WVNWcR4MHw3_xHYDlL2pLVtp1FDZN-c_YT0rXy7N4D_-mUUDT9-_vApaDoMBIpisgx4HKpYwZrHlKQZCBMa088YMSROTWJ0bDIVGSJJZtOozLaAxSlW0kiWhhTkgO-9hC5TyDFtOeE4Pu72dyzzOiOkuacTYtYrifNKNl-DGCKMg2RtLXQtA86Lc_8t1-zObP_iN3Vr4vDm_6zNW-hGE4n7u7Xp3EZbJr-Drta9Oc_uoq9jy2AxyQNXTwB68EETMxuU-7Oqrl8o_UlTj2_8vDg1UxgCK4fv7gcZ7S8Lfwq-1FfWsha-XtVn3UNfLkS0-2g7L3LzEPma4kSnmcq0hmgQgIENT7OQcqVTLiPioX4LCqEannbbLmQqXL0AZqIGkgAgCQckkXjodffOvGYp2Tj6vcVaN9IyjLsPisV30TgswZmWMUgmo1ATCG8kg0AwhOiOK4JZKj200yJLNG6vFCtYeeh59xgclj2FSnNTVPUYFtrTbg89qIHdzQRbQj5KqYfoGuTXprr-JJ-cOFJ0arn_QnjzTWscq2ltUsWr2oDWfmEwOdx1yqhmlYCUPcEgz_E5A-sUWTS8XCdiWonSiPkfG-7CaA4pScgFB8wIojEWKaFEYM14aiB9ymTyaLMun6FrYJziYG-0_xhdj6wDsfTB_R20vVxU5gm6ok6Xk3Lx1HkgH327aCP9DVTny-o |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Protein-altering+germline+mutations+implicate+novel+genes+related+to+lung+cancer+development&rft.jtitle=Nature+communications&rft.au=Ji%2C+Xuemei&rft.au=Mukherjee%2C+Semanti&rft.au=Landi%2C+Maria+Teresa&rft.au=Bosse%2C+Yohan&rft.date=2020-05-11&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-020-15905-6&rft.externalDocID=oai_DiVA_org_umu_174634 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |