Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

The basis for associations between lung cancer and major histocompatibility complex genes is not completely understood. Here the authors further consider genetic variation within the MHC region in lung cancer patients and identify independent associations within HLA genes that explain MHC lung cance...

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Published in:	Nature communications Vol. 9; no. 1; pp. 3927 - 12
Main Authors:	Ferreiro-Iglesias, Aida, Lesseur, Corina, McKay, James, Hung, Rayjean J., Han, Younghun, Zong, Xuchen, Christiani, David, Johansson, Mattias, Xiao, Xiangjun, Li, Yafang, Qian, David C., Ji, Xuemei, Liu, Geoffrey, Caporaso, Neil, Scelo, Ghislaine, Zaridze, David, Mukeriya, Anush, Kontic, Milica, Ognjanovic, Simona, Lissowska, Jolanta, Szołkowska, Małgorzata, Swiatkowska, Beata, Janout, Vladimir, Holcatova, Ivana, Bolca, Ciprian, Savic, Milan, Ognjanovic, Miodrag, Bojesen, Stig Egil, Wu, Xifeng, Albanes, Demetrios, Aldrich, Melinda C., Tardon, Adonina, Fernandez-Somoano, Ana, Fernandez-Tardon, Guillermo, Le Marchand, Loic, Rennert, Gadi, Chen, Chu, Doherty, Jennifer, Goodman, Gary, Bickeböller, Heike, Wichmann, H-Erich, Risch, Angela, Rosenberger, Albert, Shen, Hongbing, Dai, Juncheng, Field, John K., Davies, Michael, Woll, Penella, Teare, M. Dawn, Kiemeney, Lambertus A., van der Heijden, Erik H. F. M., Yuan, Jian-Min, Hong, Yun-Chul, Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Tsao, Ming-Sound, Johansson, Mikael, Grankvist, Kjell, Schabath, Matthew B., Andrew, Angeline, Duell, Eric, Melander, Olle, Brunnström, Hans, Lazarus, Philip, Arnold, Susanne, Slone, Stacey, Byun, Jinyoung, Kamal, Ahsan, Zhu, Dakai, Landi, Maria Teresa, Amos, Christopher I., Brennan, Paul
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.09.2018 Nature Publishing Group Nature Portfolio
Subjects:	45/43 692/308/174 692/308/2056 Amino acids Asian People - genetics Cancer Cancer and Oncology Cancer och onkologi Chromosome Mapping Clinical Medicine Drb1 protein Female Gene Frequency Gene mapping Genes Genetic diversity Genetic Predisposition to Disease - ethnology Genetic Predisposition to Disease - genetics Genotype Health risks Histocompatibility antigen HLA HLA Antigens - genetics Humanities and Social Sciences Humans Klinisk medicin Loci Lung cancer Lung Neoplasms - ethnology Lung Neoplasms - genetics Major histocompatibility complex Major Histocompatibility Complex - genetics Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Minority & ethnic groups multidisciplinary Peptides - genetics Polymorphism, Single Nucleotide Science Science (multidisciplinary) Single-nucleotide polymorphism White People - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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