Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

Genome-wide methylome sequencing of serial samples obtained from patients with acute myeloid leukemia reveals that epigenetic alleles and genetic alleles follow independent courses during disease evolution. Genetic heterogeneity contributes to clinical outcome and progression of most tumors, but lit...

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Veröffentlicht in:	Nature medicine Jg. 22; H. 7; S. 792 - 799
Hauptverfasser:	Li, Sheng, Garrett-Bakelman, Francine E, Chung, Stephen S, Sanders, Mathijs A, Hricik, Todd, Rapaport, Franck, Patel, Jay, Dillon, Richard, Vijay, Priyanka, Brown, Anna L, Perl, Alexander E, Cannon, Joy, Bullinger, Lars, Luger, Selina, Becker, Michael, Lewis, Ian D, To, Luen Bik, Delwel, Ruud, Löwenberg, Bob, Döhner, Hartmut, Döhner, Konstanze, Guzman, Monica L, Hassane, Duane C, Roboz, Gail J, Grimwade, David, Valk, Peter J M, D'Andrea, Richard J, Carroll, Martin, Park, Christopher Y, Neuberg, Donna, Levine, Ross, Melnick, Ari M, Mason, Christopher E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.07.2016 Nature Publishing Group
Schlagworte:	13 38/39 45/62 45/91 692/699/67/1990/283/1897 692/699/67/2329 692/699/67/68/2486 Adult Alleles Allelomorphism Biomedicine Cancer Research CpG Islands Cytosine - metabolism Disease Progression DNA Methylation Epigenesis, Genetic Epigenetics Evolution, Molecular Female Gene Expression Regulation, Leukemic Gene mutations Genetic Heterogeneity Genetics Health aspects Heterogeneity High-Throughput Nucleotide Sequencing Humans Infectious Diseases Kinetics Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Male Metabolic Diseases Methylation Middle Aged Molecular Medicine Multivariate Analysis Mutation Neurosciences Prognosis Promoter Regions, Genetic Properties Proportional Hazards Models Sequence Analysis, DNA Sequence Analysis, RNA Survival Rate Tumors
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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