Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study

Tuberculosis incidence in the UK has risen in the past decade. Disease control depends on epidemiological data, which can be difficult to obtain. Whole-genome sequencing can detect microevolution within Mycobacterium tuberculosis strains. We aimed to estimate the genetic diversity of related M tuber...

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Bibliographic Details
Published in:	The Lancet infectious diseases Vol. 13; no. 2; pp. 137 - 146
Main Authors:	Walker, Timothy M, Ip, Camilla LC, Harrell, Ruth H, Evans, Jason T, Kapatai, Georgia, Dedicoat, Martin J, Eyre, David W, Wilson, Daniel J, Hawkey, Peter M, Crook, Derrick W, Parkhill, Julian, Harris, David, Walker, A Sarah, Bowden, Rory, Monk, Philip, Smith, E Grace, Peto, Tim EA
Format:	Journal Article
Language:	English
Published:	London Elsevier Ltd 01.02.2013 Lancet Publishing Group Elsevier Limited Elsevier Science ;, The Lancet Pub. Group
Subjects:	Bacterial diseases Biological and medical sciences Cluster Analysis Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Confidence Intervals Cross-Sectional Studies Deoxyribonucleic acid Disease control Disease Outbreaks - classification DNA Genetic diversity Genetic Linkage Genome, Bacterial - genetics Households Human bacterial diseases Humans Infectious Disease Infectious diseases Longitudinal Studies Medical research Medical sciences Mutation Rate Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Observational studies Outbreaks Polymorphism, Single Nucleotide Retrospective Studies Sequence Analysis, DNA Tandem Repeat Sequences Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - transmission United Kingdom - epidemiology United Kingdom Europe British Isles Epidemic Nucleotide sequence Mycobacterial infection Epidemiology Infection Tuberculosis Mycobacterium tuberculosis Mycobacteriales Bacteriosis Mycobacteriaceae Bacteria Actinomycetes Genome Sequencing
ISSN:	1473-3099, 1474-4457, 1474-4457
Online Access:	Get full text
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