Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection

Dietary zinc supplements are in common use, but their effect on infection is unclear. New findings now show that excess dietary zinc reduces the diversity of the gut microbiota and increases the susceptibility of antibiotic-treated mice to Clostridium difficile infection. Clostridium difficile is th...

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Bibliographic Details
Published in:	Nature medicine Vol. 22; no. 11; pp. 1330 - 1334
Main Authors:	Zackular, Joseph P, Moore, Jessica L, Jordan, Ashley T, Juttukonda, Lillian J, Noto, Michael J, Nicholson, Maribeth R, Crews, Jonathan D, Semler, Matthew W, Zhang, Yaofang, Ware, Lorraine B, Washington, M Kay, Chazin, Walter J, Caprioli, Richard M, Skaar, Eric P
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2016 Nature Publishing Group
Subjects:	101/58 631/326/2565/2134 631/326/2565/855 631/326/421 64/60 692/308/575 692/499 Adult Aged Aged, 80 and over Animals Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Proteins Bacterial Toxins Biomedicine Calgranulin B - genetics Calgranulin B - metabolism Cancer Research Cecum - pathology Child Clostridioides difficile Clostridium difficile Clostridium infections Clostridium Infections - metabolism Clostridium Infections - microbiology Clostridium Infections - pathology Cohort Studies Colon Colon - pathology Cytokines - metabolism Development and progression Diet Disease Models, Animal Disease Susceptibility Enterotoxins Female Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Health aspects Humans Immune response Infections Infectious Diseases letter Male Mass Spectrometry Metabolic Diseases Mice Mice, Knockout Microbiota Microbiota (Symbiotic organisms) Middle Aged Molecular Medicine Neurosciences Nosocomial infection Nutrients Pathogens Pediatrics Polymerase Chain Reaction Prospective Studies Public health Risk factors RNA, Ribosomal, 16S - genetics Scientific imaging Toxins Trace Elements - pharmacology Young Adult Zinc Zinc (Nutrient) Zinc - pharmacology United States > US Tennessee Nashville Tennessee
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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