PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Factors traditionally associated with coagulation and inflammation, such as thrombin, PAR1, aPC and EPCR, also independently control the nitric oxide production switch in hematopoietic stem cells, thereby regulating EPCR-expressing stem cell adhesion and retention in the bone marrow or recruitment t...

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Vydané v:	Nature medicine Ročník 21; číslo 11; s. 1307 - 1317
Hlavní autori:	Gur-Cohen, Shiri, Itkin, Tomer, Chakrabarty, Sagarika, Graf, Claudine, Kollet, Orit, Ludin, Aya, Golan, Karin, Kalinkovich, Alexander, Ledergor, Guy, Wong, Eitan, Niemeyer, Elisabeth, Porat, Ziv, Erez, Ayelet, Sagi, Irit, Esmon, Charles T, Ruf, Wolfram, Lapidot, Tsvee
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.11.2015 Nature Publishing Group
Predmet:	13/1 13/100 13/31 13/51 14/19 14/63 631/250/2500 631/532/1542 64/60 82/51 82/80 ADAM Proteins - metabolism ADAM17 Protein Adhesion Animals Biomedicine Bone marrow Bone Marrow - metabolism Cancer Research cdc42 GTP-Binding Protein - metabolism Cell Adhesion Cell Movement Cellular biology Chemokine CXCL12 - metabolism Chemotherapy Coagulation Endothelial Protein C Receptor Hematology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Infectious Diseases Integrin alpha4beta1 - metabolism Metabolic Diseases Mice Mice, Inbred C57BL Microscopy Molecular Medicine Neurosciences Nitric oxide Nitric Oxide - metabolism Protein C - metabolism Protein expression Receptor, PAR-1 - metabolism Receptors, Cell Surface - metabolism Receptors, CXCR4 - metabolism Retention Signal Transduction Stem cell transplantation Stem cells Thrombin Thrombin - metabolism Israel
ISSN:	1078-8956, 1546-170X, 1546-170X
On-line prístup:	Získať plný text
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