Cardiovascular disease outcomes in relation to 25-hydroxyvitamin D and its seasonal variation: Results from the BiomarCaRE consortium
It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations. Harmonized 25(OH)...
Gespeichert in:
| Veröffentlicht in: | PloS one Jg. 20; H. 4; S. e0319607 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
Public Library of Science
24.04.2025
Public Library of Science (PLoS) |
| Schlagworte: | |
| ISSN: | 1932-6203, 1932-6203 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations.
Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72).
The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. |
|---|---|
| AbstractList | It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations.
Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72).
The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations. Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p [greater than or equal to] 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72). The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. Background It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations. Methods and findings Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality ( n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98–1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12–1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76–0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57–0.72). Conclusion The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. Background It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations. Methods and findings Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p [greater than or equal to] 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72). Conclusion The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. Background: It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations. Methods and findings: Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98–1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12–1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76–0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57–0.72). Conclusion: The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations.BACKGROUNDIt has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations.Harmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72).METHODS AND FINDINGSHarmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72).The present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD.CONCLUSIONThe present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. BackgroundIt has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined the association between CVD and (i) seasonality of 25-hydroxyvitamin D (25[OH]D) and (ii) individual 25(OH)D concentrations.Methods and findingsHarmonized 25(OH)D data were obtained from the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project, including 79,570 participants examined between 1984 and 2010. One 25(OH)D measurement was available per participant. Primary endpoints were CVD incidence (coronary heart disease or stroke; n = 6006) and CVD mortality (n = 2985). To study (i), Poisson regression-derived rate ratios were compared according to two-month categories, ordered by baseline 25(OH)D concentrations. To study (ii), Cox regression-derived hazard ratios were compared according to quarters of baseline 25(OH)D concentrations. With respect to (i), despite a median 25(OH)D concentration ratio of 1:1.79, the trough months of 25(OH)D in March and April had a similar CVD incidence as the peak months of 25(OH)D in August and September (rate ratio: 1.07, 95% CI: 0.98-1.17). CVD mortality was slightly higher in the trough months compared to the peak months (rate ratio: 1.27, 95% CI: 1.12-1.44) but not compared to the other months (despite median 25[OH]D concentration ratios up to 1:1.62; p ≥ 0.077). The CVD mortality peak in January preceded the 25(OH)D trough, not adhering to the temporality criterion of Bradford Hill. With respect to (ii), compared to the lowest quarter, the highest quarter of 25(OH)D was associated with lower CVD incidence (hazard ratio: 0.82, 95% CI: 0.76-0.89) and CVD mortality (hazard ratio: 0.64, 95% CI: 0.57-0.72).ConclusionThe present study does not support the hypothesis that seasonal increases in CVD are driven by short-term reductions in 25(OH)D. As in most observational studies, higher 25(OH)D concentrations were inversely associated with CVD. |
| Audience | Academic |
| Author | Oskarsson, Viktor Woodward, Mark Jousilahti, Pekka Costanzo, Simona Iacoviello, Licia Donfrancesco, Chiara Peters, Annette Thorand, Barbara Ferrario, Marco M. Cesana, Giancarlo Tunstall-Pedoe, Hugh Zeller, Tanja Blankenberg, Stefan Kuulasmaa, Kari Palmieri, Luigi Sans, Susana Söderberg, Stefan Salomaa, Veikko |
| AuthorAffiliation | 15 German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany 14 The George Institute for Global Health, University of New South Wales, Sydney, Australia 2 Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland 4 Formerly at the Department of Health, Generalitat of Catalunya, Barcelona, Spain 12 Institute of Cardiovascular Research, University of Dundee, Dundee, Scotland 3 Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità-ISS, Rome, Italy Public Library of Science, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND 9 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 6 Department of Medicine and Surgery, LUM University, Casamassima (Bari), Italy 17 Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany 10 Institute for Medical Information Processing, Biometry, and Epidemiol |
| AuthorAffiliation_xml | – name: 14 The George Institute for Global Health, University of New South Wales, Sydney, Australia – name: 6 Department of Medicine and Surgery, LUM University, Casamassima (Bari), Italy – name: 13 The George Institute for Global Health, Imperial College London, London, United Kingdom – name: 7 Department of Medicine and Surgery, University of Insubria, Varese, Italy – name: 11 German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany – name: 12 Institute of Cardiovascular Research, University of Dundee, Dundee, Scotland – name: 3 Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità-ISS, Rome, Italy – name: 9 Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany – name: 2 Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland – name: 16 University Center of Cardiovascular Science, University Heart and Vascular Center, Hamburg, Germany – name: 10 Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universität (LMU), Munich, Germany – name: 15 German Center for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Luebeck, Hamburg, Germany – name: 17 Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany – name: 8 Department of Medicine and Surgery, University of Milano Bicocca, Milan, Italy – name: 18 Population Health Research Department, University Heart and Vascular Center, Hamburg, Germany – name: 4 Formerly at the Department of Health, Generalitat of Catalunya, Barcelona, Spain – name: 1 Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden – name: 5 Research Unit of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, Italy – name: Public Library of Science, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND |
| Author_xml | – sequence: 1 givenname: Viktor orcidid: 0000-0002-2936-2895 surname: Oskarsson fullname: Oskarsson, Viktor – sequence: 2 givenname: Veikko orcidid: 0000-0001-7563-5324 surname: Salomaa fullname: Salomaa, Veikko – sequence: 3 givenname: Pekka surname: Jousilahti fullname: Jousilahti, Pekka – sequence: 4 givenname: Luigi orcidid: 0000-0002-4298-2642 surname: Palmieri fullname: Palmieri, Luigi – sequence: 5 givenname: Chiara surname: Donfrancesco fullname: Donfrancesco, Chiara – sequence: 6 givenname: Susana surname: Sans fullname: Sans, Susana – sequence: 7 givenname: Licia surname: Iacoviello fullname: Iacoviello, Licia – sequence: 8 givenname: Simona orcidid: 0000-0003-4569-1186 surname: Costanzo fullname: Costanzo, Simona – sequence: 9 givenname: Marco M. surname: Ferrario fullname: Ferrario, Marco M. – sequence: 10 givenname: Giancarlo surname: Cesana fullname: Cesana, Giancarlo – sequence: 11 givenname: Barbara orcidid: 0000-0002-8416-6440 surname: Thorand fullname: Thorand, Barbara – sequence: 12 givenname: Annette surname: Peters fullname: Peters, Annette – sequence: 13 givenname: Hugh surname: Tunstall-Pedoe fullname: Tunstall-Pedoe, Hugh – sequence: 14 givenname: Mark surname: Woodward fullname: Woodward, Mark – sequence: 15 givenname: Tanja surname: Zeller fullname: Zeller, Tanja – sequence: 16 givenname: Stefan surname: Blankenberg fullname: Blankenberg, Stefan – sequence: 17 givenname: Kari orcidid: 0000-0003-2165-1411 surname: Kuulasmaa fullname: Kuulasmaa, Kari – sequence: 18 givenname: Stefan orcidid: 0000-0001-9225-1306 surname: Söderberg fullname: Söderberg, Stefan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40273111$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-238715$$DView record from Swedish Publication Index (Umeå universitet) |
| BookMark | eNqNk91u1DAQhSNURH_gDRBYQkJwsYsd5297g8q2QKVKlQr01prYk11XTrzY8dI-AO-N092ipqoQ8kWi8XeOxyeZ_WSnsx0myUtGp4yX7MOVDa4DM13F8pRyNito-STZYzOeToqU8p1777vJvvdXlOa8KopnyW5G05IzxvaS33NwSts1eBkMOKK0R_BIbOilbdET3RGHBnptO9JbkuaT5Y1y9vpmrXto4-4xgU4R3XsyKG1siazB6VvFIblAH0zca5xtSb9E8knbFtwcLk6ItJ23rtehfZ48bcB4fLF9HiQ_Pp98n3-dnJ1_OZ0fnU1kyXk_SbOKNpDNZiWwrKoRah7rCihijTSHgvK0yWguKyUrqHOUpcJKpSqvJVRqxg-S1xvflbFebBP0IoaXZRUf1kFyuiGUhSuxcjo2eyMsaHFbsG4hILYsDYpC0abJpKKpVFlWy7rmdNZQCpJLiCdHr8nGy__CVahHbsf68ujWLbRBpLwqWR75j9vuQt2iktj1DsxINt7p9FIs7FqwlKYsJhId3m0dnP0Z0Pei1V6iMdChDZuLFjnNiyKibx6gj8expRYQb6y7xsaD5WAqjipe0ngoY5GaPkLFpbDV8Stjo2N9JHg_EkSmx-t-AcF7cfrt4v_Z88sx-_Yeu0Qw_dJbE4Z_0Y_BV_ej_pvx3WBE4HADSGe9d9gIGf_3wSdeTRvBqBim8C40MUyh2E5hFGcPxHf-_5T9AenIOU8 |
| CitedBy_id | crossref_primary_10_3390_nu17132102 |
| Cites_doi | 10.1136/jech.57.10.784 10.3390/nu10030277 10.1093/eurheartj/ehab809 10.1093/aje/kwq005 10.1016/j.clnesp.2024.04.018 10.1016/j.numecd.2017.11.008 10.1371/journal.pone.0284647 10.1016/j.ajcnut.2023.07.012 10.1093/ije/dyh327 10.1136/bmj.l4673 10.1373/clinchem.2004.041954 10.1136/bmjopen-2017-020545 10.5740/jaoacint.17-0196 10.1093/ije/dyv078 10.1158/1055-9965.EPI-12-0026 10.1080/01635580903191460 10.1093/ajcn/79.3.362 10.1186/s12916-019-1401-y 10.1093/ajcn/nqab419 10.1017/S1368980019005251 10.1515/cclm-2016-0566 10.1371/journal.pone.0170791 10.1016/j.jacc.2011.02.051 10.1210/jendso/bvac187 10.1136/bmj.g6330 10.1186/s12937-019-0485-8 10.1017/S0007114521005080 10.1161/JAHA.120.017727 10.1186/s12872-019-1236-7 10.1007/s10654-014-9952-x 10.1016/j.cca.2017.06.018 10.1080/14017431.2019.1612084 10.1016/S2213-8587(21)00345-4 10.7326/M21-3324 10.1016/S2213-8587(21)00263-1 10.1001/jamacardio.2019.1870 10.4103/1947-2714.110430 10.1007/s10654-023-01075-4 10.3945/ajcn.116.140392 10.1136/bmj.39335.541782.AD 10.1373/clinchem.2008.117366 10.1038/s41525-021-00250-4 10.3389/fnut.2022.910949 10.1093/ije/10.4.337 10.1093/ije/dyv092 10.1136/jech.2004.028514 10.1016/S2213-8587(23)00364-9 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2025 Public Library of Science 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2025 Oskarsson et al 2025 Oskarsson et al 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: Copyright: © 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. – notice: COPYRIGHT 2025 Public Library of Science – notice: 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2025 Oskarsson et al 2025 Oskarsson et al – notice: 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU COVID D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM ADHXS ADTPV AOWAS D8T D93 ZZAVC DOA |
| DOI | 10.1371/journal.pone.0319607 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & allied health premium. Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College Coronavirus Research Database ProQuest Materials Science Collection ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) SWEPUB Umeå universitet full text SwePub SwePub Articles SWEPUB Freely available online SWEPUB Umeå universitet SwePub Articles full text DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection Coronavirus Research Database ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Cardiovascular disease and 25-hydroxyvitamin D |
| EISSN | 1932-6203 |
| ExternalDocumentID | 3194483838 oai_doaj_org_article_6d0ff4cd02cd44bcbb309f00ac3cac7d oai_DiVA_org_umu_238715 PMC12021148 A837014811 40273111 10_1371_journal_pone_0319607 |
| Genre | Journal Article |
| GeographicLocations | Europe Germany Italy Sweden United States--US |
| GeographicLocations_xml | – name: Europe – name: Germany – name: United States--US – name: Italy – name: Sweden |
| GrantInformation_xml | – fundername: ; – fundername: ; grantid: G0601463, No. 80983: Biomarkers in the MORGAM Populations – grantid: FP7, HEALTH-F2-2011-278913 – grantid: FP7, HEALTH-F3-2010-242244 – grantid: Biomed, BMH4-CT98-3183 – grantid: FP5, QLG2-CT-2002-01254 – grantid: Horizon 2020, No. 847770 – grantid: Horizon 2020, No. 825903 – grantid: FP7, HEALTH-F4-2007-201413 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ADRAZ ALIPV CGR CUY CVF ECM EIF IPNFZ NPM RIG BBORY PMFND 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K COVID DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM ADHXS ADTPV AOWAS D8T D93 ZZAVC |
| ID | FETCH-LOGICAL-c733t-2480fa4997a148beab3733da0eebe05a6032f405c8dc8ab5ec7de8d2d5bca8d93 |
| IEDL.DBID | FPL |
| ISICitedReferencesCount | 2 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001488706700050&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Wed Aug 13 01:18:28 EDT 2025 Tue Oct 14 19:04:46 EDT 2025 Tue Nov 04 16:59:07 EST 2025 Tue Nov 04 02:03:59 EST 2025 Fri Sep 05 17:25:43 EDT 2025 Tue Oct 07 07:41:06 EDT 2025 Sat Nov 29 13:47:55 EST 2025 Sat Nov 29 10:27:39 EST 2025 Wed Nov 26 10:45:16 EST 2025 Wed Nov 26 10:45:18 EST 2025 Tue Jun 10 02:10:33 EDT 2025 Mon Jul 21 05:51:39 EDT 2025 Tue Nov 18 21:39:38 EST 2025 Sat Nov 29 07:59:30 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Copyright: © 2025 Oskarsson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c733t-2480fa4997a148beab3733da0eebe05a6032f405c8dc8ab5ec7de8d2d5bca8d93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: Abbott Diagnostics provided test reagents for the 25(OH)D measurements within the frame of the BiomarCaRE project. Abbott Diagnostics had no role in the study design, data collection, blood sample and data analysis, decision to publish, or preparation of the manuscript. Veikko Salomaa has received an honorarium from Sanofi for consulting and has ongoing research collaboration with Bayer Ltd (both outside of the submitted work). Mark Woodward has done consultancy work for Amgen and Freeline (outside of the submitted work). Stefan Blankenberg has recieved research funding from Abbott Diagnostics, Bayer, SIEMENS, Singulex, and Thermo Fisher; speaker fees from Abbott, Abbott Diagnostics, Astra Zeneca, Bayer, AMGEN, Medtronic, Pfizer, Roche, SIEMENS Diagnostics, SIEMENS, and Thermo Fisher; and honoraria as a member of advisory boards and for consulting for Bayer, Novartis, and Thermo Fisher (all outside of the submitted work). Stefan Söderberg has recieved speaker fees and done consultancy work for Merck Sharp & Dohme and Actelion Pharmaceuticals Ltd, a Johnson & Johnson company (both outside of the submitted work). This does not alter our adherence to PLOS ONE policies on sharing data and materials. |
| ORCID | 0000-0001-9225-1306 0000-0002-8416-6440 0000-0003-4569-1186 0000-0001-7563-5324 0000-0002-4298-2642 0000-0002-2936-2895 0000-0003-2165-1411 |
| OpenAccessLink | http://dx.doi.org/10.1371/journal.pone.0319607 |
| PMID | 40273111 |
| PQID | 3194483838 |
| PQPubID | 1436336 |
| PageCount | e0319607 |
| ParticipantIDs | plos_journals_3194483838 doaj_primary_oai_doaj_org_article_6d0ff4cd02cd44bcbb309f00ac3cac7d swepub_primary_oai_DiVA_org_umu_238715 pubmedcentral_primary_oai_pubmedcentral_nih_gov_12021148 proquest_miscellaneous_3194650566 proquest_journals_3194483838 gale_infotracmisc_A837014811 gale_infotracacademiconefile_A837014811 gale_incontextgauss_ISR_A837014811 gale_incontextgauss_IOV_A837014811 gale_healthsolutions_A837014811 pubmed_primary_40273111 crossref_citationtrail_10_1371_journal_pone_0319607 crossref_primary_10_1371_journal_pone_0319607 |
| PublicationCentury | 2000 |
| PublicationDate | 20250424 |
| PublicationDateYYYYMMDD | 2025-04-24 |
| PublicationDate_xml | – month: 4 year: 2025 text: 20250424 day: 24 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2025 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | JE Meng (pone.0319607.ref049) 2012; 21 JPM Wielders (pone.0319607.ref046) 2009; 55 A Zhou (pone.0319607.ref013) 2022; 43 V Oskarsson (pone.0319607.ref022) 2022; 128 C Agborsangaya (pone.0319607.ref045) 2010; 62 I Al Mheid (pone.0319607.ref034) 2011; 58 P Brøndum-Jacobsen (pone.0319607.ref009) 2015; 44 R Zhang (pone.0319607.ref002) 2017; 105 S Afzal (pone.0319607.ref008) 2014; 349 JK Virtanen (pone.0319607.ref020) 2022; 115 A Discacciati (pone.0319607.ref033) 2015 E von Elm (pone.0319607.ref028) 2007; 335 H Tunstall-Pedoe (pone.0319607.ref027) 2015; 44 Emerging Risk Factors Collaboration/EPIC-CVD/Vitamin D Studies Collaboration (pone.0319607.ref012) 2021; 9 X Liu (pone.0319607.ref007) 2019; 18 E Cavalier (pone.0319607.ref032) 2017; 55 AG Barnett (pone.0319607.ref024) 2005; 59 R Zhou (pone.0319607.ref005) 2018; 10 T Zeller (pone.0319607.ref031) 2014; 29 J-D Zhao (pone.0319607.ref040) 2018; 8 MF Holick (pone.0319607.ref021) 2004; 79 CT Sempos (pone.0319607.ref043) 2020; 23 M Gaksch (pone.0319607.ref003) 2017; 12 R Jorde (pone.0319607.ref048) 2010; 171 JP Sutherland (pone.0319607.ref014) 2022; 175 K Zhu (pone.0319607.ref050) 2022; 7 S Costanzo (pone.0319607.ref006) 2018; 28 M Barbarawi (pone.0319607.ref016) 2019; 4 J Huang (pone.0319607.ref004) 2017; 471 M Iqhrammullah (pone.0319607.ref037) 2024; 62 A Fang (pone.0319607.ref041) 2024; 39 S Kulathinal (pone.0319607.ref030) 2014 JD Healy (pone.0319607.ref036) 2003; 57 AB Hill (pone.0319607.ref035) 1965; 58 F Gholami (pone.0319607.ref001) 2019; 19 The Editors of The Lancet Diabetes & Endocrinology (pone.0319607.ref042) 2024; 12 J Miao (pone.0319607.ref039) 2021; 10 T Huang (pone.0319607.ref010) 2019; 17 A Evans (pone.0319607.ref029) 2005; 34 S Yuan (pone.0319607.ref011) 2021; 6 ME Arayıcı (pone.0319607.ref023) 2023; 18 T Wang (pone.0319607.ref018) 2019; 53 N Gao (pone.0319607.ref015) 2022; 9 A Fares (pone.0319607.ref025) 2013; 5 A Jayedi (pone.0319607.ref038) 2023; 118 Y Zhang (pone.0319607.ref017) 2019; 366 DM Antoniucci (pone.0319607.ref047) 2005; 51 RE Neale (pone.0319607.ref019) 2022; 10 RA Durazo-Arvizu (pone.0319607.ref044) 2017; 100 R Scragg (pone.0319607.ref026) 1981; 10 |
| References_xml | – volume: 57 start-page: 784 issue: 10 year: 2003 ident: pone.0319607.ref036 article-title: Excess winter mortality in Europe: a cross country analysis identifying key risk factors publication-title: J Epidemiol Community Health doi: 10.1136/jech.57.10.784 – volume: 10 start-page: 277 issue: 3 year: 2018 ident: pone.0319607.ref005 article-title: Lower vitamin D status is associated with an increased risk of ischemic stroke: a systematic review and meta-analysis publication-title: Nutrients doi: 10.3390/nu10030277 – volume: 43 start-page: 1731 issue: 18 year: 2022 ident: pone.0319607.ref013 article-title: Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk publication-title: Eur Heart J doi: 10.1093/eurheartj/ehab809 – volume: 171 start-page: 903 issue: 8 year: 2010 ident: pone.0319607.ref048 article-title: Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study publication-title: Am J Epidemiol doi: 10.1093/aje/kwq005 – volume: 62 start-page: 66 year: 2024 ident: pone.0319607.ref037 article-title: Association of serum vitamin D and the risk of cardiovascular diseases among diabetic patients: a systematic review and meta-analysis publication-title: Clin Nutr ESPEN doi: 10.1016/j.clnesp.2024.04.018 – year: 2015 ident: pone.0319607.ref033 – volume: 28 start-page: 298 issue: 3 year: 2018 ident: pone.0319607.ref006 article-title: Serum vitamin D deficiency and risk of hospitalization for heart failure: prospective results from the Moli-sani study publication-title: Nutr Metab Cardiovasc Dis doi: 10.1016/j.numecd.2017.11.008 – volume: 18 start-page: e0284647 issue: 5 year: 2023 ident: pone.0319607.ref023 article-title: Evaluation of 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic: a cross-sectional study and trend analysis involving 86,772 samples publication-title: PLoS One doi: 10.1371/journal.pone.0284647 – volume: 118 start-page: 697 issue: 3 year: 2023 ident: pone.0319607.ref038 article-title: Serum 25(OH)D concentration, vitamin D supplementation, and risk of cardiovascular disease and mortality in patients with type 2 diabetes or prediabetes: a systematic review and dose-response meta-analysis publication-title: Am J Clin Nutr doi: 10.1016/j.ajcnut.2023.07.012 – volume: 34 start-page: 21 issue: 1 year: 2005 ident: pone.0319607.ref029 article-title: MORGAM (an international pooling of cardiovascular cohorts) publication-title: Int J Epidemiol doi: 10.1093/ije/dyh327 – volume: 366 start-page: l4673 year: 2019 ident: pone.0319607.ref017 article-title: Association between vitamin D supplementation and mortality: systematic review and meta-analysis publication-title: BMJ doi: 10.1136/bmj.l4673 – volume: 51 start-page: 258 issue: 1 year: 2005 ident: pone.0319607.ref047 article-title: Serum 25-hydroxyvitamin D is unaffected by multiple freeze-thaw cycles publication-title: Clin Chem doi: 10.1373/clinchem.2004.041954 – volume: 8 start-page: e020545 issue: 8 year: 2018 ident: pone.0319607.ref040 article-title: Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials publication-title: BMJ Open doi: 10.1136/bmjopen-2017-020545 – volume: 100 start-page: 1234 issue: 5 year: 2017 ident: pone.0319607.ref044 article-title: The Vitamin D Standardization Program (VDSP) manual for retrospective laboratory standardization of serum 25-hydroxyvitamin D data publication-title: J AOAC Int doi: 10.5740/jaoacint.17-0196 – volume: 44 start-page: 651 issue: 2 year: 2015 ident: pone.0319607.ref009 article-title: No evidence that genetically reduced 25-hydroxyvitamin D is associated with increased risk of ischaemic heart disease or myocardial infarction: a Mendelian randomization study publication-title: Int J Epidemiol doi: 10.1093/ije/dyv078 – volume: 21 start-page: 916 issue: 6 year: 2012 ident: pone.0319607.ref049 article-title: Intraindividual variation in plasma 25-hydroxyvitamin D measures 5 years apart among postmenopausal women publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-12-0026 – volume: 62 start-page: 51 issue: 1 year: 2010 ident: pone.0319607.ref045 article-title: The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione publication-title: Nutr Cancer doi: 10.1080/01635580903191460 – volume: 79 start-page: 362 issue: 3 year: 2004 ident: pone.0319607.ref021 article-title: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis publication-title: Am J Clin Nutr doi: 10.1093/ajcn/79.3.362 – volume: 17 start-page: 160 issue: 1 year: 2019 ident: pone.0319607.ref010 article-title: Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults publication-title: BMC Med doi: 10.1186/s12916-019-1401-y – volume: 115 start-page: 1300 issue: 5 year: 2022 ident: pone.0319607.ref020 article-title: Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial: a randomized controlled trial publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqab419 – volume: 23 start-page: 1153 issue: 7 year: 2020 ident: pone.0319607.ref043 article-title: 25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis publication-title: Public Health Nutr doi: 10.1017/S1368980019005251 – volume: 55 start-page: 378 issue: 3 year: 2017 ident: pone.0319607.ref032 article-title: Analytical and clinical validation of the new Abbot Architect 25(OH)D assay: fit for purpose? publication-title: Clin Chem Lab Med doi: 10.1515/cclm-2016-0566 – volume: 12 start-page: e0170791 issue: 2 year: 2017 ident: pone.0319607.ref003 article-title: Vitamin D and mortality: individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium publication-title: PLoS One doi: 10.1371/journal.pone.0170791 – volume: 58 start-page: 186 issue: 2 year: 2011 ident: pone.0319607.ref034 article-title: Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2011.02.051 – volume: 7 start-page: bvac187 issue: 2 year: 2022 ident: pone.0319607.ref050 article-title: Longitudinal stability of vitamin D status and its association with bone mineral density in middle-aged Australians publication-title: J Endocr Soc doi: 10.1210/jendso/bvac187 – volume: 349 start-page: g6330 year: 2014 ident: pone.0319607.ref008 article-title: Genetically low vitamin D concentrations and increased mortality: Mendelian randomisation analysis in three large cohorts publication-title: BMJ doi: 10.1136/bmj.g6330 – volume: 18 start-page: 73 issue: 1 year: 2019 ident: pone.0319607.ref007 article-title: The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies publication-title: Nutr J doi: 10.1186/s12937-019-0485-8 – volume: 128 start-page: 2208 issue: 11 year: 2022 ident: pone.0319607.ref022 article-title: Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium publication-title: Br J Nutr doi: 10.1017/S0007114521005080 – volume: 10 start-page: e017727 issue: 10 year: 2021 ident: pone.0319607.ref039 article-title: Effects of vitamin D supplementation on cardiovascular and glycemic biomarkers publication-title: J Am Heart Assoc doi: 10.1161/JAHA.120.017727 – volume: 19 start-page: 248 issue: 1 year: 2019 ident: pone.0319607.ref001 article-title: The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies publication-title: BMC Cardiovasc Disord doi: 10.1186/s12872-019-1236-7 – volume: 29 start-page: 777 issue: 10 year: 2014 ident: pone.0319607.ref031 article-title: BiomarCaRE: rationale and design of the European BiomarCaRE project including 300,000 participants from 13 European countries publication-title: Eur J Epidemiol doi: 10.1007/s10654-014-9952-x – volume: 58 start-page: 295 issue: 5 year: 1965 ident: pone.0319607.ref035 article-title: The environment and disease: association or causation? publication-title: Proc R Soc Med – volume: 471 start-page: 270 year: 2017 ident: pone.0319607.ref004 article-title: Association between blood vitamin D and myocardial infarction: a meta-analysis including observational studies publication-title: Clin Chim Acta doi: 10.1016/j.cca.2017.06.018 – volume: 53 start-page: 110 issue: 3 year: 2019 ident: pone.0319607.ref018 article-title: Meta-analysis of vitamin D supplementation in the treatment of chronic heart failure publication-title: Scand Cardiovasc J doi: 10.1080/14017431.2019.1612084 – volume: 10 start-page: 120 issue: 2 year: 2022 ident: pone.0319607.ref019 article-title: The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(21)00345-4 – volume: 175 start-page: 1552 issue: 11 year: 2022 ident: pone.0319607.ref014 article-title: Vitamin D deficiency increases mortality risk in the UK biobank : a nonlinear mendelian randomization study publication-title: Ann Intern Med doi: 10.7326/M21-3324 – volume: 9 start-page: 837 issue: 12 year: 2021 ident: pone.0319607.ref012 article-title: Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(21)00263-1 – volume: 4 start-page: 765 issue: 8 year: 2019 ident: pone.0319607.ref016 article-title: Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals in 21 randomized clinical trials: a meta-analysis publication-title: JAMA Cardiol doi: 10.1001/jamacardio.2019.1870 – volume: 5 start-page: 266 issue: 4 year: 2013 ident: pone.0319607.ref025 article-title: Winter cardiovascular diseases phenomenon publication-title: N Am J Med Sci doi: 10.4103/1947-2714.110430 – volume: 39 start-page: 467 issue: 5 year: 2024 ident: pone.0319607.ref041 article-title: Vitamin D and human health: evidence from Mendelian randomization studies publication-title: Eur J Epidemiol doi: 10.1007/s10654-023-01075-4 – volume: 105 start-page: 810 issue: 4 year: 2017 ident: pone.0319607.ref002 article-title: Serum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies publication-title: Am J Clin Nutr doi: 10.3945/ajcn.116.140392 – volume: 335 start-page: 806 issue: 7624 year: 2007 ident: pone.0319607.ref028 article-title: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies publication-title: BMJ doi: 10.1136/bmj.39335.541782.AD – year: 2014 ident: pone.0319607.ref030 – volume: 55 start-page: 1584 issue: 8 year: 2009 ident: pone.0319607.ref046 article-title: Preanalytical stability of 25(OH)-vitamin D3 in human blood or serum at room temperature: solid as a rock publication-title: Clin Chem doi: 10.1373/clinchem.2008.117366 – volume: 6 start-page: 86 issue: 1 year: 2021 ident: pone.0319607.ref011 article-title: Serum calcium and 25-hydroxyvitamin D in relation to longevity, cardiovascular disease and cancer: a Mendelian randomization study publication-title: NPJ Genom Med doi: 10.1038/s41525-021-00250-4 – volume: 9 start-page: 910949 year: 2022 ident: pone.0319607.ref015 article-title: Associations between vitamin D levels and risk of heart failure: a bidirectional mendelian randomization study publication-title: Front Nutr doi: 10.3389/fnut.2022.910949 – volume: 10 start-page: 337 issue: 4 year: 1981 ident: pone.0319607.ref026 article-title: Seasonality of cardiovascular disease mortality and the possible protective effect of ultra-violet radiation publication-title: Int J Epidemiol doi: 10.1093/ije/10.4.337 – volume: 44 start-page: 1602 issue: 5 year: 2015 ident: pone.0319607.ref027 article-title: Prime mover or fellow traveller: 25-hydroxy vitamin D’s seasonal variation, cardiovascular disease and death in the Scottish Heart Health Extended Cohort (SHHEC) publication-title: Int J Epidemiol doi: 10.1093/ije/dyv092 – volume: 59 start-page: 551 issue: 7 year: 2005 ident: pone.0319607.ref024 article-title: Cold periods and coronary events: an analysis of populations worldwide publication-title: J Epidemiol Community Health doi: 10.1136/jech.2004.028514 – volume: 12 start-page: 8 issue: 1 year: 2024 ident: pone.0319607.ref042 article-title: Retraction and republication—Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(23)00364-9 |
| SSID | ssj0053866 |
| Score | 2.4874444 |
| Snippet | It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study examined... Background It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study... BackgroundIt has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study... Background: It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present... Background It has been hypothesized but seldom tested that the winter excess in cardiovascular disease (CVD) is related to hypovitaminosis D. The present study... |
| SourceID | plos doaj swepub pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0319607 |
| SubjectTerms | 25-Hydroxyvitamin D Age Aged Alfacalcidol Analysis Biology and Life Sciences Biomarkers Calcifediol Cardiac arrhythmia Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Coronary artery disease Cross-sectional studies Diabetes Dosage and administration Earth Sciences Epidemiology Ethics Europe - epidemiology Failure analysis Female Health hazards Health risks Heart diseases Heart failure Humans Incidence Male Medicine and Health Sciences Middle Aged Mortality Observational studies Prevention Risk assessment Risk factors Seasonal variations Seasonal variations (Diseases) Seasons Stroke Stroke (Disease) Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin deficiency Winter |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQqgcuiJZHAwUMQjwOaZ04T27bbSuQUEELVL1Fjh800m6y2iQr8QP438wk3qgRlcoB7WkzYyeZGY9nlJnPhLxOuNIh7KtuqjzjBqEn3TQPPPhrhJcbzZjp0PU_x-fnyeVl-vXaUV9YE9bDA_eCO4oUMyaQivlSBUEu85yz1DAmJJdCxgq9L4vTbTLV-2BYxVFkG-V47B1ZvRyuqlIfYt9OhMfHXtuIOrz-wStPVouqvink_LtycoQv2u1JZ_fJPRtM0mn_Ervkji73yK5drjV9ZzGl3z8gv2ejulNqv8vQqm3A5IC3KOna1sXRpqJ-6F79UljisikasQTqCRWlokVTUxyJ8TvdQJ7djfhA57puF0DDbhUKMSU9LqqlWM_E_JRCxl1DkF-0y4fkx9np99lH157A4MqY88b1g4QZAUlRLCBtyrXIOVxXgmnQPQtFxLhvIOSTiZKJyEMNCtGJ8lWYS5GolD8ikxJkvk-ogc04Fjpi0qSBiJIEp2EihUkl16FxCN-qI5MWnhxPyVhk3Te3GNKUXqgZKjGzSnSIO4xa9fAct_Afo6YHXgTX7i6AyWXW5LLbTM4hL9BOsr5TdXAR2RSBhEBOnueQVx0HAmyUWMHzU7R1nX36cvEPTN_mI6a3lslUIA64f981Ae-EwF0jzoMRJ7gJOSLvo1VvpVJnIBBIzTn8YOTW0m8mvxzIOClW5ZW6anueCEPoyCGP-4UxSDZAoCQP75uMlsxI9GNKWVx1-OaeD4EnPLRD3vSrazTmpLiYdupql20GAWfshU_-h1afkrs-nu3MAjD7AzJp1q1-Rnbkpinq9fPOvfwBiwKHog priority: 102 providerName: Directory of Open Access Journals – databaseName: Nursing & allied health premium. dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1db9QwLIKDB14Y42uFAQEhPh66pd8tL-h22wQSGuiA096qNB9bpbv2dm1P4gfwv7HbXKFiAiQeWztJ49iO3Tg2Ic9jT6oA9lU7kY62_cARdpL5Djxq7mRaMabb7PofopOT-PQ0-WR-uFUmrHKjE1tFLUuB_8j3gVXAkwB_Kn67vLCxahSerpoSGlfJNQdtY-DnaDrbaGKQ5TA01-W8yNk3q7O3LAu1h7d3Qiwi-8t21Gbt73XzaDkvq8sMz9_jJwdZRtud6Xjrf-d0i9w0Nikdd0y0Ta6o4jbZNlJf0VcmNfXrO-T7ZBC-Ss3xDi2bGkYE3LygKxNeR-uSuoF9_k1ipMw6r_kCoIeUF5LmdUWxJboBdA3uetviDZ2qqpkDDC-9UDBN6UFeLvhqwqdHFBz3CnyFvFncJV-Pj75M3tmmkIMtIs-rbdePmebgW0UcvK9M8cyD95IzBSzEAh4yz9VgOYpYiphngRKRVLF0ZZAJHsvEu0dGBSzaDqEa9vSIq5AJnfg8jGPshvEEOhWeCrRFvM16psJkOcdiG_O0PbqLwNvpiJoiF6SGCyxi962WXZaPv-AfIKv0uJiju31Rrs5SI_JpKJnWvpDMFdL3M5FlHks0fKzwBIcZWuQJMlraXXjtNU06xnxEQCfHscizFgPzdBQYCHTGm6pK33-c_QPS5-kA6aVB0iWQA8bvLl_AnDD_1wBzd4AJ2kYMwDsoFhuqVOlPHoaWGy6_HPy0B2OnGNxXqLLpcEK0xEOL3O8kq6esj_mWHBw3HsjcgPRDSJGft2nSHRfsV_hoi7zoxHPQ5jCfjdvlahZNCnZr5AQP_jyBh-SGi8WfmQ8MvUtG9apRj8h1sa7zavW41Tw_AGZfk84 priority: 102 providerName: ProQuest |
| Title | Cardiovascular disease outcomes in relation to 25-hydroxyvitamin D and its seasonal variation: Results from the BiomarCaRE consortium |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/40273111 https://www.proquest.com/docview/3194483838 https://www.proquest.com/docview/3194650566 https://pubmed.ncbi.nlm.nih.gov/PMC12021148 https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-238715 https://doaj.org/article/6d0ff4cd02cd44bcbb309f00ac3cac7d http://dx.doi.org/10.1371/journal.pone.0319607 |
| Volume | 20 |
| WOSCitedRecordID | wos001488706700050&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & allied health premium. customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR1rb9QwLIKND3wBxmsH4wgI8fjQ0TZ98m1328S0B9WNnQZfqjQPVmnXTtd2Ej-A_42d9g4VNgE6ydLVdtq4cWI3tkPIq4hJ5cO6asXS0ZbnO8KKM8-Bv5o7mVa2rU11_YPw6Cg6PY2TX47ibzv4LHTedzLdvCgLtYk5NwEmj6-6LAjQ2dpNDhYzL-huEHTpcddx9pYfU6V_ORevXJyX1VWG5p_xkr2qomYl2r37v324R-50NifdagfJGrmhivtkrdPqir7tSk-_e0B-jHvhqbTbvqFlU8PIBNq8oPMufI7WJXV96-y7xEiYy7zmM8BuU15ImtcVRU408-kluOOG4wOdqKo5BxwmtVAwPekoL2d8PuaTHQqOeQW-QN7MHpKT3Z3P449Wd1CDJULGasv1Iltz8J1CDt5VpnjG4LrktoIhYvs8sJmrwTIUkRQRz3wlQqki6Uo_EzySMXtEVgoQzTqhGtbskKvAFjr2eBBF2IzNY2hUMOXrAWGL95eKroo5HqZxnpqtuRC8mVaoKco67WQ9INaS66Kt4vEX-hEOjSUt1uA2F-Clpp1Kp4G0tfaEtF0hPS8TWcbsWMPDCiY49HBAnuPAStuE1uVMkm5hvSGQk-MMyEtDgXU4Cgz0-cabqkr3Pk3_geh40iN60xHpEsQB92-TK6BPWN-rR7nRo4TZRPTQ66gGC6lUKQgEPHgGP-BcqMbV6BdLNDaKwXuFKpuWJkBLOxiQx60mLSXrYT0lB-8b9XSsJ_o-psjPTBl0xwX7FB56QF636tjj2c6nW-Z1NbMmBbs0dPwn1_ftKbnt4sHOtgeDeYOs1PNGPSO3xGWdV_MhuRlOpghPQwMjgNHYGZLV0c5RMhmaDzlDMxcB3B9tAjy09xGGiYHHABP_K3Ake4fJl5-nI45- |
| linkProvider | Public Library of Science |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Zb9NAEF5VAQlegHI1UOiCOB_crm8HCaH0UquWUKWlqngx6z1aS4kdYjuoP4C_w29kxkfAogJe-sBjvLO2dzzz7Ux2DkKeBbZULuyrRk-a2nBcUxi9yDHhp-ZmpBVjuqyuv-8PBsHJSe9ggXxvcmEwrLLBxBKoZSrwP_I1EBXwJMCfCt5NvhjYNQpPV5sWGpVY7Knzr-CyZW93N-H7Pres7a2jjR2j7ipgCN-2c8NyAqY5GPo-B1cgUjyy4brkTMF6mMs9ZlsazBgRSBHwyFXClyqQlnQjwQOJxZcA8q84jsVQiw7cTw3yA3Z4Xp2eZ_vmWi0Nq5M0UauYLeRh09pftr-yS8B8L-hMRml2kaH7e7xmq6ppuRNu3_zfeHiL3KhtbtqvlGSRLKjkNlmsUS2jr-rS26_vkG8brfBcWh9f0bTIYYVAGyd0WocP0jyllmucnUuMBJrFOR_D6CbliaRxnlGciW4OnfFpJf9v6FBlxQjGMKmHgulN1-N0zKcbfLhFBeg_-EJxMb5LPl4KO-6RTgJCskSoBpvF58pjQvcc7gUB3obxHtxU2MrVXWI38hOKuoo7NhMZheXRpA_eXMXUEKUurKWuS4z5rElVxeQv9OsomnNarEFeXkinp2ENaaEnmdaOkMwS0nEiEUU262l4WWELDivskhUU7LBK6J0jadjHekvAJ9PskqclBdYhSTDQ6ZQXWRbufjj-B6LDYYvoZU2kU2AHPL9KLoE1YX2zFuVyixLQVLSGl1ANG65k4U-dgZmNVl08_GQ-jDfF4MVEpUVF46Gn4XXJ_UqT55x1sJ6Uic8NWjreYn17JInPyjLwpgX2Obx0l7yo4KA1ZzM-7pefqxgXIdjlvuk--PMCVsi1naP3--H-7mDvIbluYaNr5oBwL5NOPi3UI3JVzPI4mz4uUY-Sz5cNET8A5DbzrA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF5VBSEuQHk1UOiCeB7c-G0HCaE0aUTUqlQFqoqLWe-jtZTYIbaD-gP4U_w6Zux1wKICLj1wjHfW9o5nvp3JzoOQJ6EjpAf7qtETljJcz-JGL3Yt-KmYFStpmqqqrr8X7O-Hx8e9gxXyvcmFwbDKBhMroBYZx__IuyAq4EmAPxV2lQ6LOBiO3sy-GNhBCk9am3YatYjsyrOv4L7lr8dD-NZPbXu082Hw1tAdBgweOE5h2G5oKgZGf8DALYglix24LpgpYW2mx3zTsRWYNDwUPGSxJ3kgZChs4cWchQILMQH8XwrAx8RwwgPvU7MLAI74vk7VcwKrqyVja5alcgszh3xsYPvLVlh1DFjuC6uzSZafZ_T-HrvZqnBa7Yqj6_8zP2-Qa9oWp_1aedbIikxvkjWNdjl9oUtyv7xFvg1aYbtUH2vRrCxgtUCbpHSuwwppkVHbM07PBEYILZKCTWF0SFkqaFLkFGei-0MXbF7rxSt6KPNyAmOY7EPBJKfbSTZl8wE73KEccAF8pKSc3iYfL4Qdd8hqCgKzTqgCWyZg0je56rnMD0O8jcl6cFPuSE91iNPIUsR1dXdsMjKJqiPLALy8mqkRSmCkJbBDjOWsWV3d5C_02yimS1qsTV5dyOYnkYa6yBemUi4Xps2F68Y8jh2zp-BlucMZrLBDNlHIozrRd4mwUR_rMAGfLKtDHlcUWJ8kRck8YWWeR-N3R_9A9P6wRfRcE6kM2AHPr5NOYE1Y96xFudGiBJTlreF1VMmGK3n0U39gZqNh5w8_Wg7jTTGoMZVZWdP46IH4HXK31uolZ12sM2Xhc8OWvrdY3x5Jk9OqPLxlg90OL90hz2poaM0ZJkf96nOV0zICez2wvHt_XsAmuQLIEO2N93fvk6s29r82XZDtDbJazEv5gFzmiyLJ5w8rAKTk80UjxA-bw_x2 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cardiovascular+disease+outcomes+in+relation+to+25-hydroxyvitamin+D+and+its+seasonal+variation%3A+Results+from+the+BiomarCaRE+consortium&rft.jtitle=PloS+one&rft.au=Oskarsson%2C+Viktor&rft.au=Salomaa%2C+Veikko&rft.au=Jousilahti%2C+Pekka&rft.au=Palmieri%2C+Luigi&rft.date=2025-04-24&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=20&rft.issue=4&rft.spage=e0319607&rft_id=info:doi/10.1371%2Fjournal.pone.0319607&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |