Detecting autozygosity through runs of homozygosity: A comparison of three autozygosity detection algorithms

Background A central aim for studying runs of homozygosity (ROHs) in genome-wide SNP data is to detect the effects of autozygosity (stretches of the two homologous chromosomes within the same individual that are identical by descent) on phenotypes. However, it is unknown which current ROH detection...

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Vydáno v:	BMC genomics Ročník 12; číslo 1; s. 460
Hlavní autoři:	Howrigan, Daniel P, Simonson, Matthew A, Keller, Matthew C
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 23.09.2011 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Algorithms Alzheimer's disease Analysis Animal Genetics and Genomics Autophagy (Cytology) Biomedical and Life Sciences Bipolar disorder Chromosome Mapping Chromosomes Colorectal cancer Comparative and evolutionary genomics Computational Biology - methods Computer Simulation Genetics Genome, Human Genomes Homozygosity Homozygote Humans Leukemia Life Sciences Linkage Disequilibrium Mental health Methodology Methodology Article Microarrays Microbial Genetics and Genomics Phenotype Physiological aspects Plant Genetics and Genomics Polymorphism, Single Nucleotide Prostate cancer Proteomics Regression Analysis Schizophrenia Sequence Analysis, DNA - methods Single nucleotide polymorphisms Studies Zygote United States Linkage Disequilibrium Pattern Minor Allele Frequency Simulated Phenotype Linkage Disequilibrium Homozygous SNPs
ISSN:	1471-2164, 1471-2164
On-line přístup:	Získat plný text
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