Combinatorial screening of osteoblast response to 3D calcium phosphate/poly(ε-caprolactone) scaffolds using gradients and arrays

There is a need for combinatorial and high-throughput methods for screening cell–biomaterial interactions to maximize tissue generation in scaffolds. Current methods employ a flat two-dimensional (2D) format even though three-dimensional (3D) scaffolds are more representative of the tissue environme...

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Bibliographic Details
Published in:	Biomaterials Vol. 32; no. 5; pp. 1361 - 1369
Main Authors:	Chatterjee, Kaushik, Sun, Limin, Chow, Laurence C., Young, Marian F., Simon, Carl G.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.02.2011
Subjects:	3D scaffolds adhesion Advanced Basic Science Animals Calcium phosphate calcium phosphates Calcium Phosphates - chemistry Calcium Phosphates - pharmacology cell adhesion Cell Adhesion - drug effects cell culture Cell Line cell proliferation Cell Proliferation - drug effects Combinatorial screening culture media Dentistry ions Mice Microscopy, Fluorescence Nanoparticles Nanoparticles - chemistry Osteoblast Osteoblasts - cytology Osteoblasts - drug effects Polyesters - chemistry Polyesters - pharmacology screening Tissue engineering Tissue Engineering - methods Tissue Scaffolds - adverse effects Tissue Scaffolds - chemistry Nanoparticles Osteoblast Calcium phosphate Combinatorial screening Tissue engineering 3D scaffolds
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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