Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts

Induced pluripotent stem cell (iPSC)-technology is an important platform in medicine and disease modeling. Physiological degeneration and disease onset are common occurrences in the aging population. iPSCs could offer regenerative medical options for age-related degeneration and disease in the elder...

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Veröffentlicht in:	PloS one Jg. 14; H. 4; S. e0215490
Hauptverfasser:	Vosough, Massoud, Ravaioli, Francesco, Zabulica, Mihaela, Capri, Miriam, Garagnani, Paolo, Franceschi, Claudio, Piccand, Julie, Kraus, Marine R.-C., Kannisto, Kristina, Gramignoli, Roberto, Strom, Stephen C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 25.04.2019 Public Library of Science (PLoS)
Schlagworte:	Adult Age Age Factors Age related diseases Aged, 80 and over Aging Artificial chromosomes Autografts Cell culture Cell cycle Cells, Cultured Cellular Reprogramming Cellular Reprogramming Techniques - methods Centenarians Degeneration DNA damage EDTA Efficiency Fibroblasts Fibroblasts - physiology Genetic Vectors - genetics Genomes Geriatrics Health aspects Health sciences Humans Hydrodynamic pressure Hydrodynamics Induced Pluripotent Stem Cells - physiology Infant, Newborn Laboratories Medicine Methods Nuclear reprogramming Older people Organs Pathology Physiological aspects Pluripotency Primary Cell Culture Regeneration Regenerative medicine Reproducibility of Results Sendai virus - genetics Senescence Skin Skin - cytology Skin Aging - physiology Somatic cells Stem cells Technology Transfection - methods Transplantation, Autologous - methods Viruses Italy Switzerland Sweden
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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