Identification of novel small molecules that inhibit STAT3-dependent transcription and function

Activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been linked to several processes that are critical for oncogenic transformation, cancer progression, cancer cell proliferation, survival, drug resistance and metastasis. Inhibition of STAT3 signaling has shown a striking ab...

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Vydáno v:	PloS one Ročník 12; číslo 6; s. e0178844
Hlavní autoři:	Kolosenko, Iryna, Yu, Yasmin, Busker, Sander, Dyczynski, Matheus, Liu, Jianping, Haraldsson, Martin, Palm Apergi, Caroline, Helleday, Thomas, Tamm, Katja Pokrovskaja, Page, Brent D. G., Grander, Dan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 21.06.2017 Public Library of Science (PLoS)
Témata:	Anticancer properties Antimitotic agents Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Biochemistry Biology Biology and Life Sciences Biophysics Biotechnology Cancer Cell proliferation Cell Proliferation - drug effects Cell survival Chemical compounds Cytokines Docking Drug development Drug resistance Fluorescence Fluorescence polarization Gene expression Genetic aspects Genetic transformation Growth factors High-throughput screening High-Throughput Screening Assays - methods Humans Inhibitors Interleukin 6 Kinases Laboratories Libraries Medical screening Metastases Neoplasms - drug therapy Neoplasms - pathology Oncology Pathology Pharmacology Phosphorylation Physiological aspects Polarization Proteins Research and analysis methods Risk factors Signal Transduction Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Stat3 protein STAT3 Transcription Factor - antagonists & inhibitors Stimulation Studies Toxicity Transcription activation Transcription factors Transformation Tumor Cells, Cultured Sweden
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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